5 Anesthesia



10.1055/b-0034-82081

5 Anesthesia




  • Percutaneous endoscopic diskectomy differs from other spinal operations in that it presents particular demands for anesthesiology:




    • Limited endoscopic field



    • Poor tactile feedback obtained from long endoscopic tools



    • Surgery performed at a depth



    • Less familiar anatomy



    • Poor three-dimensional spatial orientation



  • These reasons may increase the chance of iatrogenic neural injury.



  • The safety of this procedure is amplified if the surgeon is able to assess the functional results intraoperatively by communicating with the patient.



  • In doubtful situations, the patient’s response in terms of presence of pain and movement of toes or fingers can help the surgeon to confirm and avoid injury to the neural structures.



  • Elderly patients, who are usually associated with medical problems (e.g., diabetes, hypertension, and cardiac diseases), better tolerate percutaneous procedures, both intraoperatively and postoperatively, because they can be performed under local anesthesia.



  • It is possible to perform these procedures under local anesthesia because the actual tissue dissection is very limited.



  • The procedure is based on the principle of sequential dilatation of the soft tissues.



  • The only significant pain generators during the procedure are the skin and annulus.



  • This pain and discomfort can be well negated with infiltration of local anesthetics, epidural block, and conscious sedation ( Fig. 5.1 ).



Infiltration and Epidural Anesthesia in Percutaneous Endoscopic Lumbar Diskectomy




  • The preferred choice as a local anesthetic is 1% lido-caine, with its quick onset and a duration of 1 to 1.5 hours, which is adequate for the procedure.



  • The lower concentration (1% lidocaine) is used instead of 2% because the drug in lower concentrations partially blocks the sensory nerve fibers without impairing the motor responses.



Transforaminal Approach




  • After infiltrating the skin with 1 to 2 mL of lidocaine and waiting for 1 minute, a 20-gauge thin spinal needle 5 to 7 inches in length is used to infiltrate the intermuscular planes with 5 to 10 mL of lidocaine along the intended trajectory up to the facet joint ( Fig. 5.2 ).



  • The 18 g approach needle is then inserted under fluoroscopic guidance until it reaches the epidural space just outside the annulus.



  • At this point the needle tip corresponds to the medial or midpedicular line in the anteroposterior view and the posterior vertebral line in the lateral view of fluoroscopy.



  • Lidocaine (3 to 4 mL) is injected in the epidural space just before puncturing the annulus.



  • There is a sudden release of resistance during injection of the drug if the needle is in the epidural space.



  • The space can also be confirmed by injecting a radiopaque dye to rule out intrathecal leakage ( Fig. 5.3 ).



  • This serves as a transforaminal epidural block.



  • The injected local anesthetic solution produces anal-gesia by blocking conduction at the intradural spinal nerve roots.



  • Another 1 to 2 mL is infiltrated on the outer surface of the annulus.



Interlaminar Approach




  • For an interlaminar approach we prefer a caudal epidural block given prior to the beginning of the operation for two reasons ( Fig. 5.4 ).




    • A caudal block given prior to the operation provides sufficient time to achieve pain relief before the insertion of the sequential dilators and the working cannula, which is a very painful procedure.



    • The irrigation fluid from the endoscope inserted through the epidural space immediately following an epidural injection washes out the drug before it starts taking effect, without causing sufficient analgesia.



  • An additional infiltration of the outer surface of the annulus provides adequate pain relief during the procedure.



Conscious Sedation




  • Conscious sedation is a medically controlled state of depressed consciousness that allows protective reflexes to be maintained while retaining the patient’s ability to keep the airway patent independently and continuously and permitting appropriate responses to physical stimulation and verbal commands.13

Fig. 5.1 Use of different types of anesthesia in percutaneous endoscopic lumbar diskectomy (PELD).



  • A combination of a sedative and an opioid analgesic is most commonly used for this purpose.



  • Anxiety and procedure-related pain are the two major reasons for the use of sedatives.



  • Midazolam is used in combination with either remifentanil or fentanyl or propofol or the combination of remifentanil and propofol.



Conscious Sedation in Percutaneous Endoscopic Lumbar Diskectomy




  • Conscious sedation begins in the ward when the patient is administered 3 mg of midazolam (0.05 mg/kg) intramuscularly by the ward nurse 1 hour before the surgery.



  • In the operating room, after the patient is placed in the prone position, the anesthetist may repeat half the initial dose of midazolam intravenously (IV) if the patient is not feeling sleepy.

Fig. 5.2 (A,B) Infiltration of skin and intermuscular planes with lidocaine.
Fig. 5.3 (A,B) C-arm pictures showing leakage of the dye.



  • Continuous blood pressure, oxygen saturation, and echocardiographic monitoring is mandatory during conscious sedation.



  • Supplemental oxygen is administered with a Venturi mask.



  • We prefer remifentanil as the additional drug because of its very short duration of action (3 to 4 minutes), which is independent of the dose and duration of use.4




    • It is started as a continuous infusion with an infusion pump at a dose of 1 μg/kg/min.



    • The dose is decreased to 0.5 μg/kg/min after the most painful part of the procedure (i.e., after the insertion of the working sleeve through the annulus).



    • The dose may be increased at times of increased pain.



  • The common side effects of remifentanil are respiratory depression, pruritis, and difficulty in voiding, especially in the elderly.



  • The infusion should be stopped immediately if there is a drop in the oxygen saturation.



  • Remifentanil does not have an analgesic effect, which makes it easier for the surgeon to assess the success of surgery by performing the straight leg raising test immediately after the operation.



  • If fentanyl is used, it is administered as a bolus dose of 50 μg (0.8 μg/kg) before the beginning of the operation.




    • The peak effect of action is usually 8 minutes.



    • The dose can be repeated 3 to 5 minutes before insertion of the obturator in the annulus or if there is continuing pain during the procedure to a total dose of 150 μg.



  • Propofol, if used, should be administered as a continuous infusion with the help of target-controlled infusion (TCI) pumps, which control accurate delivery of the drug and ensure careful monitoring.



Selection of Sedative Agents




  • Short-acting agents are preferred to long-acting ones.



  • Continuous infusions as opposed to bolus injections provide an equivalent level of sedation with a smaller total drug dose.



  • An analgesic agent is valuable during anticipated periods of painful stimulation.

Fig. 5.4 A caudal epidural block given prior to the beginning of the operation.


Anesthesia in Percutaneous Cervical Diskectomy



Infiltration Anesthesia




  • Because of the loose arrangement of the deep cervical fascia and the free mobility of the tracheoesophageal complex over the vertebral bodies, there is a natural plane between the tracheoesophageal complex on the medial side and the common carotid sheath on the lateral side.



  • Moderate pressure applied with the fingers in an effort to separate these structures pushes the skin close to the disk, making it possible to palpate the cervical spine.



  • For this reason infiltration of the superficial skin with 2 to 3 mL of lidocaine suffices for the insertion of the working cannula.



  • The outer surface of the annulus is also infiltrated to allow pain-free insertion of the obturator into the disk space.



  • Epidural block is not given during cervical diskectomy because the approach is from the anterior side ( Fig. 5.5 ).



Conscious Sedation




  • Conscious sedation is achieved in essentially the same way as that used during percutaneous endoscopic lumbar diskectomy.



  • Some surgeons prefer general anesthesia for cervical diskectomy especially if the patient is anxious.

Fig. 5.5 The natural plane between the tracheoesophageal complex and the common carotid sheath is shown.


Patient-Controlled Analgesia




  • As we know conscious sedation is achieved with a combination of sedative hypnotics such as midazolam with opiate narcotics.57



  • Dose-related complications account for the majority of complications associated with IV sedation for the following reasons:




    • Variations in the pain threshold and drug tolerance make it impossible to anticipate the required dose of sedative medication.



    • Estimating the dosage of sedative medications appropriate for the individual patient can be difficult, and overdosing is more likely in elderly patients.



    • Furthermore, patient versus physician assessments of discomfort during procedures differ significantly. As a consequence some patients are given inadequate medication, whereas others are oversedated with associated risk of cardiorespiratory complications and delayed recovery.



  • To overcome these problems, patient-controlled anal-gesia (PCA) delivery systems were introduced as early as 1968. Since then many trials support the safety and efficacy of PCA for various syndromes.



  • An important difference between PCA and nurse-administered sedation is that the latter, because of its continuous mode of administration, is associated with general discomfort such as nausea, vomiting, and excessive sedation, whereas episodic pain can be well controlled with intermittent, need-based administration via PCA.



Patient-Controlled Analgesia Unit




  • PCA uses a medication-dispensing unit equipped with a pump attached to an IV line, which is inserted into a blood vessel in the patient’s hand or arm.



  • By means of a simple push-button mechanism, the patient is allowed to self-administer doses of pain-relieving medication (narcotic) as needed.



  • However, prior to release from the hospital, the patient is weaned from the PCA and given oral medication to control pain ( Fig. 5.6 ).



  • A typical PCA algorithm contains a bolus dose, a lockout interval, and a maximum number of bolus doses per hour but contains no background infusion.



  • Hypnotic and sedative effects of propofol and opiates both have rapid onset and termination of action making them ideal choices for PCA.



  • The physician determines the dosage based on the patient’s weight to prevent an overdose.



  • The PCA unit is programmed to control the dosage, and the unit locks out if the dosing frequency is exceeded.

Fig. 5.6 The patient-controlled analgesia unit is shown.



  • After a loading dose of 20 mg of propofol IV patients are instructed to press the button as often as required to relieve discomfort. The PCA pump is programmed to deliver a bolus of 10 mg over 1 minute.

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Jul 12, 2020 | Posted by in NEUROSURGERY | Comments Off on 5 Anesthesia

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