7 Types of Hydrocephalus



10.1055/b-0036-141982

7 Types of Hydrocephalus

David S. Xu and Peter Nakaji


7.1 Introduction


Hydrocephalus is one of the oldest neurologic pathologies recorded in human history, with multiple descriptions by Galen and Hippocrates.1 Despite the passage of more than two millennia from these early accounts, hydrocephalus remains a common, enigmatic, and challenging entity to treat. Most modern surgical management strategies for obstructive and nonobstructive hydrocephalus have followed evolving cerebrospinal fluid (CSF) shunting strategies. However, recent advances in our understanding of hydrodynamic dysfunctions underlying hydrocephalus have spurred intervention strategies that focus on restoring normal physiologic CSF circulation rather than on external drainage. Neuroendoscopy, a vital tool in the minimally invasive paradigm, affords maximum access to the ventricular system. This chapter briefly describes the different types of hydrocephalus, their pathophysiologic and hydrodynamic bases, and the implications of endoscopic intervention.



7.2 Pathophysiology



7.2.1 Obstructive Hydrocephalus


The traditional definition of obstructive hydrocephalus stems from work in 1914 by Dandy and Blackfan.2 It refers to obstruction of bulk CSF flow, leading to dilatation and isolation of the proximal ventricular system from the subarachnoid space. Obstructive hydrocephalus includes forms of hydrocephalus in which a physical obstruction within the ventricular system, or its outlet from the brain, impedes CSF flow. The level of the obstruction can vary, and it can occur over the entire span of the ventricular system, from the foramen of Monro to the third ventricle, the cerebral aqueduct, the fourth ventricle, and its outlets. Notable common etiologies of obstructive hydrocephalus include congenital or acquired stenosis of the foramen of Monro or the aqueduct, obstruction by parasites causing conditions such as neurocysticercosis, or tumors and arachnoid cysts that cause compression due to direct mass effect (Fig. 7.1, Video 7.1 and Video 7.2).

Fig. 7.1 Obstructive hydrocephalus. (a) An axial non–contrast-enhanced computed tomogram demonstrates diffuse subarachnoid hemorrhage with an intraventricular clot causing acute obstructive hydrocephalus. (b) An axial T2-weighted magnetic resonance (MR) image demonstrates a neurocytoma that has trapped the right lateral ventricle, resulting in univentricular hydrocephalus. (c) A sagittal T1-weighted gadolinium-enhanced MR image reveals a large pineocytoma that has compressed most of the third ventricle, resulting in biventricular obstructive hydrocephalus. (d) An axial T2-weighted MR image in an infant demonstrates an arachnoid cyst that has trapped the right temporal horn, resulting in its dilatation and transependymal cerebrospinal fluid flow. (e) A sagittal T2-weighted MR image demonstrates triventricular hydrocephalus in the setting of idiopathic aqueductal stenosis (arrowhead). (f) A sagittal T1-weighted gadolinium-enhanced MR image shows a medullary exophytic mass causing obstruction of the fourth ventricle, resulting in tetraventricular hydrocephalus. (Reproduced with permission of Barrow Neurological Institute, Phoenix, Arizona.)


7.2.2 Communicating Hydrocephalus


Communicating hydrocephalus, also known as non-obstructive hydrocephalus, has been described in terms of CSF malabsorption resulting from a diverse list of possible etiologies. This type of hydrocephalus encompasses all cases in which the flow of CSF is obstructed at a point distal to the outlet of CSF from the brain (i.e., the foramina of Luschka and Magendie). This can occur within the subarachnoid space or at the level of the arachnoid granulations. Common causes of communicating hydrocephalus include infections, intracranial hemorrhage, and trauma that lead to scarring and adhesions within the subarachnoid space. Equally common are idiopathic and congenital cases—usually presenting in the pediatric population—and normal pressure hydrocephalus, which occurs in the aging adult. However, the differentiation between obstructive and communicating hydrocephalus is somewhat arbitrary. All forms of hydrocephalus involve an obstructive element, either physical within the ventricular system (classic obstructive hydrocephalus) or functional within the arachnoid villi or subarachnoid space (communicating hydrocephalus).


A new model of CSF hydrodynamics has emerged within the past 15 years that pinpoints decreased brain compliance as a unifying pathophysiology for communicating hydrocephalus, regardless of its etiology.3, 4 Multiple studies have examined pulse pressure transmission and CSF flow states in patients with chronic communicating hydrocephalus, and brain compliance is found to be nearly one order of magnitude lower in these patients.5,6,7 This diminished state of brain compliance increases the pulse pressure transmitted from the arterial system to the brain, consequently raising transmitted pulse pressure through the brain and ventricles. This compresses cerebral vessels and further hinders circulatory absorption of CSF (Fig. 7.2). Therefore, the central pathophysiology underpinning communicating hydrocephalus may be alterations in the ventricular and parenchymal compliance, distorting pulse, and perfusion-dependent circulation of CSF.

Fig. 7.2 Compliance model of chronic communicating hydrocephalus. (a) During early systole, blood reaches the arterial system, and, due to the low compliance of the system, there is little dampening of pulse pressure and minimal expansion of the brain. As a result, minor bulk flow of cerebrospinal fluid occurs that does not compress the dural bridging veins. The venous outflow (white arrows) is consequently maximal and the veins are prone to collapse. (b) During midsystole, the undampened arterial pulse pressure reaches the capillary system and causes a large expansion of the brain and ventricles, resulting in compression of the venous system (red arrows) across its length that reduces blood flow and cerebrospinal fluid resorption. (Reproduced with permission of Barrow Neurological Institute, Phoenix, Arizona.)


7.2.3 Extraventricular-Intracisternal Obstructive Hydrocephalus


The type of hydrocephalus known as extraventricular-intracisternal obstructive hydrocephalus results from obstruction of the basal cisterns. The basal subarachnoid spaces play an important role in the circulation of CSF, and they are also vulnerable to insult.7,8,9 Subarachnoid hemorrhage, trauma, and infection (e.g., meningitis or arachnoiditis) can cause basal subarachnoid inflammation, adhesions, and scars that reduce intracranial compliance by different mechanisms.7,10 These adhesions can also cause obstruction of the basal cisterns. Experimental models have shown that adhesions of the basal subarachnoid spaces have a stronger effect than an intraventricular obstruction on the development of hydrocephalus.11 Additional studies have indicated that any process that interferes with the expansion of the arteries in the basal subarachnoid space may cause hydrocephalus.7,8,12



7.2.4 Multiloculated Hydrocephalus


Neoepithelial loculations that develop in patients with hydrocephalus typically occur after infection or hemorrhagic events and result in multicompartmentalized CSF spaces. In 1973, Schultz and Leeds13 described the etiology of these septations as originating from glial tufts that protruded through eroded areas of ependyma after infectious meningitis (Fig. 7.3 a,b). The inciting and perpetuating offender appears to be a continuous inflammatory response to debris created after the initial insult, as well as continued disruption of the membranes that arise during interventions or shunt overdrainage.14 Other causative and continuous biological mechanisms of multiloculated hydrocephalus remain unknown.

Fig. 7.3 Loculated hydrocephalus. (a) An axial non-contrast–enhanced computed tomogram reveals diffuse encephalomalacia and multiloculated cerebrospinal fluid collections in a patient who had multiple previous shunt infections. Some septations are visible in the left occipital horn. (b) Sagittal T2-weighted magnetic resonance (MR) image illustrates multiple septations in the right ventricle of a patient with postmeningitic hydrocephalus. (c) A lateral radiograph in a patient with loculated hydrocephalus reveals a complex shunt system linked up to multiple intracranial catheters, which is also evident (d) on the axial view. Axial T2-weighted MR imaging (e) before and (f) after endoscopic fenestration of loculations in the right lateral ventricle shows decreased ventricle size as well as communication of the large loculation in the body of the ventricle. (Reproduced with permission of Barrow Neurological Institute, Phoenix, Arizona.)

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Jun 1, 2020 | Posted by in NEUROSURGERY | Comments Off on 7 Types of Hydrocephalus

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