Fig. 28.1
Post-concussion symptom inventory
Physical and Neurologic Exam
The physical exam of the head may show lacerations, bruises, or other signs of impact from the injury. However, it is important to note that the site of injury to the head does not reflect any damage referred to the brain. As noted previously, coup-contrecoup and rotational forces are far more important than the site of the external impact. The neurologic examination is usually normal except very early nystagmus or other extraocular movement deficits, pupillary changes, mild ataxia or dysmetria observed on cerebellar testing, and anosmia (it is helpful to include CN I given its sensitivity to TBI from orbital frontal abrasions from the cribriform plate). It is recommended to spend more time than usual on the cerebellar part of the exam, including tests of upper extremity coordination (finger-to-nose as well as finger-nose-finger), lower extremity coordination (heel-to-shin), and gait (normal, tandem, heel walking, toe walking). A useful and sensitive adjunct to the cerebellar examination is the Balance Examination Scoring System (BESS; [14]). This exam is part of the SCAT-3 [2] and many other PCS tools and is quick and easy to administer. There are three lower extremity stances utilized: feet together, tandem stance, and (for older children) standing only on the nondominant leg. Detailed instructions are given in the SCAT-3 form that is available for download from the CDC.
Diagnosis and Feedback
Counseling the child and parent on the natural course of concussion is obviously important. The intense media attention given to concussion has produced a near-hysteria among some parents and schools, and you may be asked if the concussion sustained will leave the child at risk for two of the buzzwords frequently occurring in the popular press: second impact syndrome and chronic traumatic encephalopathy.
Second Impact Syndrome
This is a controversial outcome of concussion. It was originally depicted as sudden death following a concussion within the context of a recent previous concussion and was attributed to rapid cerebral swelling from dysautoregulation occurring after the second concussion [6]. However, most cases of “second impact syndrome” were single-case studies and had little or nothing to do with a preceding concussion when reviewed in detail [20]. Instead, diffuse cerebral swelling is a well-recognized complication of a single TBI that is more common in children and adolescents. As such, the presence of a prior concussion can be pure coincidence, and some have proposed that the term “second impact syndrome” be abandoned and replaced by a single episode of diffuse cerebral swelling [20]. In addition, some media reports of “second impact syndrome” have simply been the result of an epidural, subdural, or subarachnoid hemorrhage, either in isolation or as a result of a ruptured aneurysm or arteriovenous malformation with a coincidental prior concussion. However, there is a recent report of a second concussion occurring before the resolution of a CT-confirmed first concussion that resulted in rapid cerebral edema with severe and permanent sequelae [23]. The presence of a profound and persistent headache could indicate the presence of cerebral swelling and should be investigated by an ED experienced in TBI.
Second impact syndrome has mistakenly also come to mean a concussion sustained before a first concussion has fully resolved. This phenomenon is quite real [22]. It is very important to make sure that the child has recovered fully from reliable signs and symptoms of a concussion before resuming activities (especially contact sports) in which there is a possibility of a subsequent concussion. Factors such as balance problems, visual difficulties, and slowed responses may make the child more prone to sustain an injury resulting in a concussion. The brain itself is more vulnerable to an impact resulting in concussion if there is a prior concussion, such that a “hit” that would previously have not resulted in any meaningful injury can result in a second concussion. How long to avoid activities that could produce a concussion is somewhat controversial and will be discussed below under return to play with respect to contact sports .
Chronic Traumatic Encephalopathy
The term does not refer to a newly discovered disorder, but instead is simply a renaming of an older term called “dementia pugilistica” that referred to dementia with a unique histological pattern confirmed at autopsy resulting from multiple sub-concussive blows and concussions sustained by professional boxers. Although there are some anatomical differences between what is now called CTE arising from non-boxing contact sports and dementia pugilistica, both are an autopsy-proven deposition of the tau protein predominantly in the frontal and temporal lobes and localized to perivascular areas deep in the sulci. It is very important to stress to the parents that CTE can only be diagnosed at autopsy, that is, it occurs only in contact sports with frequent blows to the head over a long period of time. Even if a child has sustained previous concussions, reassure the parents and child that there is no scientific evidence that another concussion will produce CTE, especially in a child.
Although the terms mild traumatic brain injury and concussion are sometimes used interchangeably, in providing feedback it would probably be best to emphasize the term concussion so as not to alarm the child or parents. Explain that the latter term by definition necessitates evidence of actual structural damage to the brain, whereas concussion produces transient changes in neurochemical functioning that completely remit and do not leave any permanent damage to the brain. Under ICD-10, concussion is diagnosed S06.0X0 (without LOC ) or S06.0X1 (LOC < =30 min) and in ICD-9 as 850.0 (no LOC) or 850.1 (LOC <30 min). In ICD-9, although the term “concussion” is used for longer durations of LOC, these should more correctly be termed mild traumatic brain injury.
The diagnosis of post-concussion syndrome should be made only if signs or symptoms linger beyond a 2–6-week period of recovery (or longer in younger children). Care should be given on how feedback is provided regarding the likelihood of psychological or complex biopsychosocial factors that could be maintaining symptomatology. Some patients, including children, may have a somatization disorder that contributes to the maintenance of these symptoms. Feedback that is too abrupt or direct about the absence of a medical explanation for the symptoms could “pull the rug out” from a patient who is relying on the diagnosis for psychological reasons.
Treatment Plan and Recommendations
When to Refer for an Emergent Neurosurgical Consultation
Immediate transfer to a hospital should be arranged if a child shows any of the following, either at your examination or from parent report after the visit:
Glasgow Coma Scale less than 15
Deteriorating mental status
Behaves unusually, seems confused, or is overly irritable
Cannot recognize people or places
Potential spinal injury
Progressive, worsening symptoms or new neurologic signs
Weakness, numbness, unsteady walking or standing, slurred speech
Difficulty understanding speech or directions
Worsening headache
Persistent, severe vomiting
Evidence of skull fracture (otorrhea, rhinorrhea, meningeal signs)
Posttraumatic seizures
Coagulopathy
History of neurosurgery (e.g., shunt)
Multiple injuries
The CDC has a useful handout available to parents for what to look out for in the first 24–48 h after a concussion (http://www.cdc.gov/concussion).
Recommendations for Return to School and to Sports
This is a difficult decision for a pediatrician to make. Most importantly, the child must never return to any sport or active play on the same day as a suspected concussion. The first few days after a concussion, the child may have a wide range of symptoms of varying severity. There is no hard and fast rule about when to recommend that a child stay out from school. Instead, these recommendations should be individualized to the specific child’s symptoms, severity, and school circumstances. It was once thought that children (and adults) should avoid all activities involving sustained concentration, such as schoolwork, for a period of time after the injury. However, more recently experts have suggested that a child who is mildly to moderately symptomatic return to school, but with instructions to report to the school nurse and/or return home if class work exacerbates any symptoms. Prolonged absences from school should be avoided unless the signs and symptoms of the concussion are especially severe, given that the child can be stressed by later having to catch up with missed exams or projects. Additionally, some concentration in school (or at home) can be beneficial, much like patients who have back pain benefit more from mild exercise or activity than from going on bed rest. The schools may be overly conservative and want the child held out, but they should be informed in writing of what your opinions are and what you recommend. Accommodations may be offered to assist the child in returning to school, such as shortened school days, fewer classes, rest breaks, reduced workload, and extended time for tests.
Determining when the child may return to sports is also difficult; most guidelines were researched and developed for professional athletes first and then adapted for children. Professional sports such as football (NFL) and hockey (NHL) have very well-researched and reasonable guidelines for return to practice and play, generally following the recommendations of the 4th International Conference on Concussion in Sport and those listed on the CDC’s website. These organizations recommend that the athlete begin an escalating program of exercise after the patient is symptom-free or has symptoms equivalent to baseline and has neuropsychological testing that is normal or equivalent to baseline. ImPACT testing, the BESS, and re-administration of the Child-SCAT3 can be helpful in tracking recovery of cognitive and motor functioning. However, be aware that an athlete may have intentionally produced poor ImPACT scores at baseline in anticipation of retesting after a concussion to be able to return to play faster or hurried through the battery without sufficient effort at baseline.
A typical exercise program would include riding a stationery bicycle up to a heart rate of 120 and then 160 bpm on 1 day, weight or strengthening exercise on a second day, noncontact practice on a third day, and finally practice with contact or equivalent intensity on subsequent days. If at any time the exercise produces any symptoms, the program should back down to the previous step (as long as that does not cause symptoms). Take steps to ensure that coaches, PE teachers, and athletic trainers are informed of this graduated approach.
Recommendations for activities at home or away from school should be similar. Video games, TV, and computers do not necessarily have to be avoided and, like classroom work, may be of some benefit as long as the concussion signs and symptoms are not severe. Again, titrating the activities to the child’s reaction is the best plan of action. For both home and school, gradually increasing the amount of time spent in activities requiring sustained concentration helps speed recovery and curtails the tendency of some children to become chronic patients. Also be cognizant of secondary gain. Some children may enjoy the attention they receive while at home, and prolong their symptoms (consciously or subconsciously) to avoid school, chores at home, etc. and enjoy being told to rest while at home.
Medication
There is no medication that will facilitate the recovery from a concussion. Instead, the signs and symptoms that occur following a concussion can be treated individually. Headache is the most common complaint that is amenable to medication. However, any medication should be avoided or minimized in the first 24–48 h to assure that a possible hemorrhage is not developing that could be masked by analgesics. It is common to have headaches persist throughout the recovery period. Clinicians differ in their views on treating continuing headaches, with some encouraging their patients to avoid analgesics. However, a number of neurologists have been prescribing amitriptyline, an older tricyclic antidepressant, for posttraumatic headaches with reported success. Although there have been no controlled studies on this drug, anecdotal reports suggest that it can be beneficial. If the child has a history of migraines or if the posttraumatic headaches resemble idiopathic migraines, medication used in treating classic migraine could be considered until the headaches subside.
When to Refer for a Neuropsychological Consultation
Patients may be referred for consultation by a neuropsychologist if assistance is needed in determining an appropriate return to play and especially return to school timeline. Evaluation should be performed by a neuropsychologist familiar with sports-related concussion. The American Academy of Clinical Neuropsychologists (AACN) provides a directory of board-certified clinicians which may be helpful in identifying a qualified consulting neuropsychologist (http://www.theaacn.org).