Adolescent Substance-Use Disorders



Adolescent Substance-Use Disorders


Oscar G. Bukstein MD, MPH



Introduction

Substance use by adolescents remains an important public health problem due to the potential consequences of use, including accidents; the possible progression of use into the substanceuse disorders (SUDs); and the persistence of SUDs into adulthood. Because of both health and mental health consequences of substance use, all health care professionals need to have a basic understanding of the risk for substance use and abuse by adolescents, the acquisition of use behaviors, and progression into SUDs within a developmental framework. As substance use is a common behavior for adolescents, primary health care professionals often must act as gatekeepers for adolescents, screening for SUDs and related problems, and refer adolescents for more comprehensive substance-use evaluation and treatment. To achieve optimal results, an understanding of assessment and screening and other assessment procedures as well as treatment should include the knowledge of evidence-based interventions which focus on specific substance-use behaviors, as well as risk factors that have a role in the onset and maintenance of SUDs.


Clinical Features

There is a range of substance-use behaviors and patterns of use from abstinence through to substance use, often without significant consequences or impairment, and on to substancerelated diagnoses, abuse and dependence, as defined by the Diagnostic and Statistical Manual, Fourth Edition (DSM-IV). Substance use per se is not sufficient for a diagnosis of abuse or dependence, even in adolescents.

The diagnosis of substance abuse requires evidence of a maladaptive pattern of substance use with clinically significant levels of impairment or distress. Recurrent use by adolescents results in an inability to meet major role obligations, leading to impaired functioning in one or more major areas of their life and an increased likelihood of legal problems due to possession, risk-taking behavior, and exposure to hazardous situations. The diagnosis of substance dependence requires that the adolescent meet at least three criteria, including such symptoms as withdrawal, tolerance, and loss of control over use. For example, for alcohol-use disorders (AUDs), adolescents commonly exhibit tolerance (i.e., requiring increasing amounts of a substance to achieve the same effect) but less frequently show withdrawal or other symptoms of physiologic dependence. Many adolescents do manifest withdrawal symptoms with cannabis and opiate-use disorders. Preoccupation with use is often demonstrated by giving up previously important activities, increasing the time spent in activities related to substance use, and using more frequently or for longer amounts of time than planned. The adolescent may use these substances despite the continued existence or worsening of problems caused by substance use. Polysubstance use by adolescents appears to be the rule
rather than the exception; therefore, adolescents often present with multiple SUD diagnoses. Adolescents’ alcohol and drug symptom profiles often appear to vary along a severity dimension, rather than fitting into the DSM-IV categories of abuse and dependence categories.

Misuse and diversion are nonstandard terms that indicate behaviors may or may not result in an SUD diagnosis in adolescents. The term misuse can be defined as use for a purpose not consistent with medical guidelines including modifying dose, using to achieve euphoria, and/or using with other nonprescribed psychoactive substances. The term diversion is the transfer of medication from the individual for whom it was prescribed to one for whom it is not prescribed. While abuse and dependence are terms that connote psychopathology related to substance use, diversion and misuse are not. Diversion and misuse of prescription drugs are widespread, especially in high school and college students.


Epidemiology


The Prevalence of Substance-Use Disorders

The prevalence of SUDs increases with age through young adulthood when both SUDs and substance use peak. Data from the National Survey on Drug Use and Health indicate that very few youth (less than 3%) met criteria for any past-year SUD prior to age 14. SUDs increased steadily from age 14 (7%) to age 21 (25%), with peak prevalence occurring in the 20s. Among 12- to 17-year-olds, 9% met criteria for a past-year DSM-IV SUD abuse or dependence diagnosis, 6% had an alcohol-related diagnosis, and 4% had a cannabis diagnosis; 2% met criteria for use of both alcohol and at least one illicit substance. However, other studies show considerable variation of rates, especially when sampling different-aged adolescents. Recent national survey data indicate little to no difference in rates of past-year SUD prevalence by gender for alcohol or illicit drugs. Similar to ethnic differences in the prevalence of substance use, larger proportions of Caucasian and Hispanic youth aged 12 to 17 years met criteria for a past-year DSM-IV alcohol or drug diagnosis than African Americans (10%, 10%, and 6%, respectively), although American Indian adolescents had the highest proportion of alcohol or other drug diagnoses (20%).


The Prevalence of Substance Use

According to the National Survey on Drug Use and Health, the rates of current illicit drug use among youths aged 12 to 17 were 11.6% in 2002 and 9.9% in 2005. In 2005, 9.9% of youths aged 12 to 17 were current illicit drug users: 6.8% used marijuana, 3.3% used prescriptiontype drugs nonmedically, 1.2% used inhalants, 0.8% used hallucinogens, and 0.6% used cocaine. In 2008, adolescents in the United States continued to show a gradual decline in their use of certain drugs, especially stimulants including amphetamines, methamphetamine, crystal methamphetamine, cocaine, and crack, according to the Monitoring the Future (MTF) annual national survey of the US students in 8th, 10th, and 12th grades.


Rates of Intervention

Only a small percentage of adolescents with SUDs actually receive treatment. Among youths aged 12 to 17, there were 1.3 million (4.9%) who needed treatment for an illicit drug use problem in 2005. Of this group, only 142,000 received treatment at a specialty facility, that is, 11.3% of youths aged 12 to 17 who needed treatment, leaving 1.1 million youths who needed such treatment but did not receive it. Among 12- to 17-year-olds in publicly funded programs, most were referred by the criminal justice system, with smaller proportions referred by schools or family; rates of self-referral to treatment begin to increase in young adulthood.









TABLE 6-1 Essential Risk Factors for the Development of Substance-Use Disorders in Adolescents















































Individual factors


Early disruptive behavior disorder, for example, ADHD


Early aggressive behavior, for example, conduct disorder


Poor academic performance, school failure


Positive beliefs and attitudes about substance use


Peer-related factors


Peer substance use


Peer beliefs and attitudes about substance use


Earlier involvement with peers and away from family


Earlier involvement with peers and away from family


Parental substance use


Parental beliefs and attitudes about substance use


Parent tolerance of substance use


Lack of closeness or attachment between parent and child


Poor parental supervision and monitoring of child/adolescent


Sociocultural factors


Sociocultural factors


Low socioeconomic status


High population density


Physical deterioration


High crime


Media messages about substance use



Risk Factors

The early onset of substance use and a more rapid progression through the stages of substance use are among the risk factors for the development of SUDs. The literature on the development of substance use and SUDs in adolescents has identified a variety of individual, peer, family, and community risk factors, as summarized in Table 6-1. Within a developmental context, genetic predispositions to affective, cognitive, and behavioral problems are exacerbated by family and peer factors leading to early-onset substance use and pathologic use. Family factors identified as increasing SUD risk in children and adolescents include decreased affectional bonding, decreased parental supervision, and decreased adherence to religious beliefs. A harsher parental discipline style and affiliation with socially deviant peers have been shown in many studies to promote substance use.


Comorbidity

In both community surveys of adolescents with SUD and samples of adolescents in addictions treatment, the majority have a co-occurring non-substance-related mental disorder. More than half of adolescents in addictions treatment who have a co-occurring mental illness have three or more psychiatric disorders, which are summarized in Table 6-2. The most common disorders include conduct problems, attention-deficit/hyperactivity disorder (ADHD), mood disorders (e.g., depression), and trauma-related symptoms. Among treated adolescents, comorbid psychopathology generally predicted early return to substance use, particularly
conduct problems and major depression. Co-occurring psychopathology also generally predicted a more persistent course of substance involvement over 1-year follow-up.








TABLE 6-2 Comorbid Disorders





































Disruptive behavior disorders


• Conduct disorder


• Oppositional defiant disorder


• Attention-deficit/hyperactivity disorder


• Mood disorders


• Major depressive disorder: single episode vs. recurrent episodes


• Bipolar disorder


• Dysthymic disorder


• Cyclothymia


Anxiety disorders


• Social phobia


• Posttraumatic stress disorder


• Generalized anxiety disorder


• Panic disorder


Other disorders


• Schizophrenia


• Bulimia nervosa



Clinical Course

The clinical course of AUDs in community samples suggests some remission with maturation, as well as a more chronic course of adolescent-onset AUD for certain individuals. Although the majority of treated adolescents return to some substance use following treatment, they generally show reductions in substance use and problems over both short- and longer-term follow-up. Despite significant reductions in substance involvement and improvements in school performance, interpersonal relations, and other areas, treated adolescents continue to show greater problem severity across multiple domains compared to a community comparison sample, showing that adolescent-onset SUD, likely in combination with co-occurring psychopathology and other risk factors, interferes with the achievement of normative adolescent developmental tasks.


Assessment

There are two levels of assessment: screening and comprehensive assessment. Screening is a process in which adolescents are identified according to characteristics that indicate that they possibly have a problem with substance use. Screening does not inform the clinician of the severity of the adolescent’s substance use or the presence of SUDs but rather identifies the need for a comprehensive assessment. It is not a substitute for an assessment. For primary health care professionals, screening is a critical task as these professionals are among the potential gatekeepers for adolescents with SUDs. The comprehensive assessment is a thorough process that includes inquiry of factors contributing to and maintaining substance abuse, the severity of the problems, and the variety of consequences associated with the adolescent’s substance use.









TABLE 6-3 CRAFFT





















C


Have you ever ridden in a car driven by someone (including self) high, drunk, or using drugs


R


Have you ever used drugs or alcohol to Relax?


A


Do you ever use Alone?


F


Do you ever Forget things that you did while using?


F


Do Family or Friends tell you to cut down?


T


Have you ever gotten into Trouble when using?



Screening

In order to screen large numbers of youth, clinicians and others such as school professionals, mental health professionals, and primary health care professionals often rely on the use of screening instruments. The two alternative approaches to screening involve (1) specific screening of substance use and related behaviors, focusing on this behavior alone, and (2) screening for SUD as part of a multidomain screen that includes mental health problems and high-risk behaviors. In a primary care setting, questions for all youth about substance use follow a general inquiry about health behaviors and should include questions about cigarette, alcohol, and other substance use. In settings such as child welfare, mental health, or juvenile justice, the high-risk status is sufficient to require screening of each adolescent. Primary health care staff (e.g., physicians and nurses) may use a brief series of questions to screen for substance-use problems. Although specific interview questions with established validity, such as the CRAFFT (see Table 6-3), are often sufficient, many clinicians or other relevant professionals use other specific screening instruments.

Professionals need to decide what screening threshold will trigger a comprehensive assessment. The CRAFFT has a threshold of two positive items. Other factors, such as past history of substance use, high-risk behaviors, and moderate to severe high-risk status, may prompt such a referral even in the absence of an adolescent report of regular use or consequences.


Comprehensive Assessment

The assessment process is used to identify those individuals who have an SUD and whether they meet criteria for a DSM-IV diagnosis. Substance-using behaviors, the pattern of use, and any consequences of use are also discussed. The results of the comprehensive assessment should also identify which adolescents require treatment, the level of treatment needed, and other problems that may need intervention. Many screening and comprehensive assessment instruments follow the Domain Model of assessment, shown in Table 6-4, that provides a review of the primary domains of adolescent functioning, including substance-use behaviors, psychiatric and behavioral problems, school and occupational functioning, family functioning, social competency and peer relations, and leisure and recreation.


The Interview

As primary health care professionals often have a long-standing relationship with the adolescent and his or her family, they are in an optimal position to track developmental risk factors that may lead to substance use and SUDs as well as identify these problems. Screening through the use of the CRAFFT allows for screening through a conversational format of a series of questions. Some primary care professionals may elect to proceed to a more comprehensive substance-use history, inquiring about age of onset, duration, frequency, and route of ingestion for each individual drug including alcohol, tobacco, illicit drugs, inhalants, over-the-counter medications,
and prescription drugs such as benzodiazepines, opiates, and stimulants. Additional questions should cover negative consequences as well as attempts and motivation to control use or quit. Questions detailing the context of use include the setting of use (time and place), whether the adolescent uses alone or with peers, and the attitudes of these peers about substance use. Variability in quantity and frequency of adolescent substance use is often great. The adolescent may report periods of abstinence as well as periods of rapid acceleration of use and heavy use of particular agents. A timeline drug chart or calendar is often useful to allow the adolescent to report quantity, frequency, and variability data across time with important dates, holidays, and other time cues as a guide. Additional substance-use-related information includes attitudes, expectancies of use, and motivation(s) or perceived benefits to use. Assessment of substance-use behavior may follow a functional analysis of use to determine usual antecedents to use and consequences of use. Such an analysis may allow a more specific targeting of relevant antecedents during treatment. Along with specific attitudes and beliefs about substance use, the interviewer may also inquire about the adolescent’s values and attitudes in general.

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Jun 29, 2016 | Posted by in PSYCHIATRY | Comments Off on Adolescent Substance-Use Disorders

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