Angina
Evaluation
Description—chest pain in conjunction with myocardial ischemia, not myocardial necrosis
Types
Typical (all three are present) versus atypical (two are present) versus noncardiac (one present)
Pain located in chest, shoulder, arm, or jaw
Worsens with stress (physical or emotional)
Relieved by nitroglycerin
Differential diagnosis of acute chest pain
Cardiovascular
Stable angina
Acute coronary syndrome (ACS)—need hospital admission and cardiology care
Unstable angina—myocardial ischemic pain at rest, of new onset, or increase in severity
Non-ST elevation myocardial infarction (NSTEMI)
ST elevation myocardial infarction (STEMI)
Evidence of myocardial infarction (MI) (+ troponin)
Equal to or greater than 1 mm of new ST segment elevation in more than two leads
Aortic dissection—acute sharp chest pain that radiates to the back
Pericarditis/myocarditis—sharp, pleuritic pain that is positional
Non-cardiovascular
Pulmonary (eg., pulmonary embolism—pleuritic chest pain, dyspnea, cough, hemoptysis)
Musculoskeletal (eg., costochondritis—this pain may be reproducible on examination)
Psychiatric (eg., anxiety, etc.)
Management of stable angina
Order
EKG—get within 5 minutes of the patient presenting with symptoms suggestive of angina.
Q waves in concordant leads suggest prior infarct.
EKG signs are suggestive of ACS.
ST-segment elevation or depression
Inverted T waves, including “pseudonormalization” of previously flipped T waves
Stress testing—it is used to risk-stratify patients with angina.
May also use stress testing to diagnose coronary disease as a cause of chest pain
Pathophysiology—patients with angina experience chest pain when O2 demand is greater than O2 supply.
Treatment—aims to reverse the pathophysiological imbalance described in the preceding text.
Improve long-term outcomes
Decreases adverse cardiovascular events by 33% in patients with stable angina.
Lipid-lowering agents (eg., statins, etc.)
Improve symptoms
Nitrates—arterial and venous vasodilators → increase coronary blood flow.
Short-acting
Long-acting
Nitroglycerin transdermal 0.2 to 0.4 mg per hour patch dailya
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