Anxiety Disorders and Sleep
James D. Geyer
Paul R. Carney
Kenneth L. Lichstein
ANXIETY DISORDERS
Anxiety disorders are characterized by inappropriate or excessive activation of the “fight or flight” system, resulting in central nervous system components of fear and worry and peripheral effects reflecting activation of the sympathetic nervous system. For these reasons, anxiety potently disrupts sleep. Anxiety disorders are the most common comorbid conditions found in insomnia patients, occurring in 24% to 36% of individuals diagnosed with insomnia (1,2). Anxiety and insomnia are strongly inter-related. Not only does anxiety contribute to insomnia, but insomnia increases the likelihood of developing a subsequent anxiety disorder compared to individuals without insomnia (14% vs. 7%) (2). Insomnia occurs frequently with generalized anxiety disorder (GAD), but it is much less commonly associated with certain phobias and obsessive compulsive disorder (OCD). Patients with OCD who have a compulsion to repeatedly check doors before going to bed or any other similar compulsion can have significant sleep-onset insomnia (3). Likewise, phobias associated with nighttime, such as phobias regarding the dark, being alone, or those with social phobia the night before a feared social circumstance is scheduled to occur, are more likely to have impaired sleep.
Generalized Anxiety Disorder
Overview, Epidemiology, and Course
GAD is characterized by the persistence and chronicity of both central and peripheral symptoms of anxiety. Patients with GAD experience excessive worry associated with various physical symptoms on most days for extended periods of time (see the Diagnostic Criteria for GAD in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision). These individuals are often described as “worriers,” who appear to have excessive concerns. The patients are often aware of this exaggerated response but are unable to change their responses or behavior.
The lifetime prevalence of GAD has been estimated to be 5%. Somatic complaints are common and are often the presenting symptoms of GAD (4,5). A large percentage of patients diagnosed with GAD report a lifelong history of anxiety. The disorder usually relapses following the termination of treatment (60%-80% in the first year) (4,5).
Differential Diagnosis
Anxiety may occur as a component of a normal response to an event or condition, GAD, and posttraumatic stress disorder. A much more challenging aspect of the differential diagnosis is the patient who presents with somatic complaints. These complaints include nausea, dry mouth, muscle soreness, twitching, tension, urinary frequency, sweating, swallowing difficulties, chest pain, sexual dysfunction, and insomnia (5).
Sleep Disturbance in Generalized Anxiety Disorder
Treatment
Treatment options for GAD include a number of pharmacologic agents: benzodiazepines, buspirone (a serotonin 1A receptor agonist), selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, venlafaxine (serotonin and norepinephrine reuptake inhibitor), and trazodone (some serotonin reuptake inhibition and serotonin 2 and 3 receptor antagonism) (6,7,8,9 and 10). Limited comparative data exist
regarding these treatments. Depression is frequently comorbid with GAD, and this has led some to recommend that the antidepressants with demonstrated efficacy, namely, venlafaxine, paroxetine, and tricyclic antidepressants, may be preferable in the long-term treatment of this condition (11). It is, however, important to note that some of these antidepressants can result in sleep disruption in some individuals.
regarding these treatments. Depression is frequently comorbid with GAD, and this has led some to recommend that the antidepressants with demonstrated efficacy, namely, venlafaxine, paroxetine, and tricyclic antidepressants, may be preferable in the long-term treatment of this condition (11). It is, however, important to note that some of these antidepressants can result in sleep disruption in some individuals.

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