Attention-Deficit Disorders
Attention-deficit/hyperactivity disorder (ADHD) is the most common behavioral disorder among children in the United States. It is a behavioral and neurocognitive condition characterized by inattention, hyperactivity, or both lasting for at least 6 months. The onset is typically before age 7 years. Although ADHD begins in childhood, fewer than 40 percent of such children continue to meet diagnostic criteria in their teenage years. In studies, adults with childhood histories of ADHD were found to have higher rates of accidents, injuries, health problems, pregnancies, and job and marital problems. Although prevalence estimates for ADHD vary by country and region, as well as by age, a pooled estimate of worldwide prevalence is 5.29 percent. This figure showed the most variation geographically between Europe and North America.
The disorder has been identified in the literature for many years under a variety of terms. In the early 1900s, impulsive, disinhibited, and hyperactive children—many of whom had neurological damage caused by encephalitis—were grouped under the label hyperactive syndrome. In the 1960s, a heterogeneous group of children with poor coordination, learning disabilities, and emotional lability but without specific neurological damage were described as having minimal brain damage. Since then, other hypotheses have been put forth to explain the origin of the disorder, such as genetically based condition involving abnormal arousal and poor ability to modulate emotions. This theory was initially supported by the observation that stimulant medications help produce sustained attention and improve these children’s ability to focus on a given task. Currently, no single factor is believed to cause the disorder, although many environmental variables may contribute to it, and many predictable clinical features are associated with it.
Students should test their knowledge by addressing the following questions and answers.
Helpful Hints
Students should know the following terms.
adult manifestations
ambidexterity
body anxiety
clonidine (Catapres)
disinhibition
disorganized EEG pattern
EEG findings
genetic-familial factors
growth suppression
hyperactivity-impulsivity
hyperkinesis
locus ceruleus
matching familiar faces
minimal brain damage
nonfocal (soft) signs
perceptual-motor problems
PET scan
rebound effect
right–left discrimination
school history
secondary depression
sympathomimetic
Questions
Directions
Each of the questions or incomplete statements below is followed by five suggested responses or completions. Select the one that is best in each case.
42.1 Which of the following statements regarding tricyclic antidepressant (TCAs) is not true?
A. The TCAs are known to slow cardiac conduction.
B. A common side effect of TCAs is constipation.
C. The TCAs are more effective than stimulants.
D. The TCAs are often administered in divided doses to reduce side effects.
E. The TCAs are rarely used to treat children with ADHD.
View Answer
42.1 The answer is C
The fact that the TCAs are less effective than stimulants for ADHD and have a much more serious side effect profile (with fatigue, sedating, and cardiovascular side effects) have made them much less popular with patients and clinicians. Cardiovascular adverse events are the most serious adverse events of these medications and are thought to explain why these medications are rarely used in children with ADHD. Several cases of sudden death have been reported in children taking TCAs. Cardiovascular adverse events include the slowing of cardiac conduction, increasing the electrocardiographic (ECG) reading of the PR and QRS intervals. For that reason, many clinicians monitor the PR interval and do not enroll patients in the treatment if that interval exceeds 0.2 second. Such slowing increases the risk of cardiac arrhythmias and heart block. Although the TCAs have not proven to be the cause of these deaths, ECGs at baseline and after each dose adjustment need to be taken in routine monitoring of the PR interval.
Other side effects might be commonly experienced. These include cholinergic side effects, such as constipation, dry mouth, or blurred vision. To minimize side effects, the TCAs are given to children and adolescents in divided doses.
42.2 Findings from neuroimaging studies of subjects with ADHD include which of the following?
A. Reduced perfusion in bilateral frontal areas on positron emission tomography (PET)
B. Increased perfusion in prefrontal, striatal, and thalamic regions in response to methylphenidate administration on PET scan
C. Dorsal anterior cingulate cortex (DACC) dysfunction on functional magnetic resonance imaging (fMRI)
D. Abnormalities in frontostriatal brain regions on various imaging techniques
E. All of the above
View Answer
42.2 The answer is E (all)
Structural and functional neuroimaging techniques have contributed significantly to the evolving understanding of the etiology of ADHD. Across a range of techniques, including positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), and magnetic resonance spectroscopy (MRS), a consistent finding has been abnormalities in frontostriatal brain regions. These discoveries are in keeping with clinical observations of ADHD patients that suggest deficits in attention, self-regulation, cognition, working memory, motor control, and other functions that are principally mediated by frontostriatal structures, particularly DACC. In general, underactivity in implicated areas, for example, reduced perfusion in bilateral frontal areas on PET scan and DACC dysfunction on fMRI scan is thought to correspond to key behavioral and emotional difficulties that characterize ADHD. Further evidence for the connection between frontostriatal dysfunction and ADHD symptoms and treatment is provided by the observation of increased perfusion in prefrontal, striatal, and thalamic regions in response to methylphenidate administration, as measured on PET scan.
42.3 Which of the following statements describing the genetics of ADHD is true ?
A. The risk of ADHD for a sibling of a child proband with ADHD increases up to five times in some studies.
B. Children with ADHD are at no greater risk of developing conduct disorder than children of similar ages without ADHD.
C. Concordance rates for ADHD range from 25 to 40 percent for monozygotic twins.
D. Concordance rates for ADHD range from 5 to 10 percent for dizygotic twins.
E. The heritability of inattention-related behaviors is estimate to range between 40 and 55 percent.
View Answer
42.3 The answer is A
There is ample and compelling evidence for a genetic basis for ADHD. Most published controlled family studies report significantly higher risks of ADHD in first- and second-degree relatives of probands with ADHD compared with normal control subjects. For example, the risk of ADHD in siblings of child probands is increased by between 1.8 and 5 times. Analyses of twin studies have provided further evidence of a genetic influence in ADHD: concordance rates for monozygotic twins range from 51 to 80 percent (not 25 to 40 percent) and for dizygotic twins range from 29 to 33 percent (not 5 to 10 percent).


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