Indication: cerebellar degeneration

Tumor: breast, ovarian, endometrial, cervical

Clinical features: cerebellar symptoms evolve over weeks to months and then stabilize.

Pathologic finding: destruction of cerebellar Purkinje cells.

Cerebrospinal fluid (CSF): lymphocytic pleocytosis, increased protein and IgG.

Levels: positive at 1:2,000

Treatment: <10% respond to plasmapheresis, intravenous IgG, steroid, cyclophosphamide.

Indication: sensory neuronopathy, limbic encephalitis

Tumor: small-cell lung cancer, prostate

Clinical features: sensory neuropathy, limbic encephalitis, ataxia, autonomic dysfunction, and mononeuritis multiplex are the most common presentations.