A 63-year-old man presented with progressive memory, concentration, mood, and behavior problems over several years. He was a veteran of the army for six years in his twenties, and reported being “knocked out” or “dazed” more than a dozen times while in combat. In the army he also boxed competitively for several years and frequently had his “bell rung,” although he reported only being knocked unconscious five times. After the army he married and owned a successful small business. For the past 4–5 years his wife noted that he became increasingly withdrawn and moody. After making several poor financial decisions he closed down his business. In the last three years he began very uncharacteristic behaviors including yelling and “flying off the handle” over minor issues. His primary care physician referred him to a psychiatrist who prescribed fluoxetine, which improved his mood and anger. Two years ago his mood and anger worsened, and increasing doses of fluoxetine and other selective serotonin reuptake inhibitors (SSRIs) could not control the symptoms; after an episode of physical aggression toward his wife risperidone was prescribed. In the past year he had clear-cut impairment of his concentration, memory, and function. His wife notes that he now has “no short-term memory” and that he “does nothing” all day long. Neurological examination revealed mild bilateral 3–4 Hz tremor present at rest and with action. He scored 15 on the MoCA, making errors on the visuospatial/executive, attention, delayed recall, and orientation sections. Head CT revealed atrophy (most notably in hippocampi and frontal lobes, bilaterally) and a cavum septum pellucidum.