Corpus Callosum Mass
Karen L. Salzman, MD
DIFFERENTIAL DIAGNOSIS
Common
Glioblastoma Multiforme
Lymphoma, Primary CNS
Anaplastic Astrocytoma
Less Common
Oligodendroglioma
“Tumefactive” Multiple Sclerosis
Gliomatosis Cerebri
Lipoma
Rare but Important
“Tumefactive” ADEM
Enlarged Perivascular Spaces
ESSENTIAL INFORMATION
Helpful Clues for Common Diagnoses
Glioblastoma Multiforme
Heterogeneously enhancing mass
Classically crosses corpus callosum (CC), results in a “butterfly glioma”
Central necrosis, blood products typical
Lymphoma, Primary CNS
Homogeneously enhancing, T2 hypointense mass
Usually involves basal ganglia, periventricular white matter (WM)
Often crosses CC, extends along ependymal surfaces
Anaplastic Astrocytoma
T2 hyperintense WM mass with variable enhancement
Often involves, crosses CC
Helpful Clues for Less Common Diagnoses
Oligodendroglioma
Calcified frontal lobe mass involving cortex/subcortical WM
May extend into CC
Heterogeneous enhancement 50%
“Tumefactive” Multiple Sclerosis
CC lesions characteristic
Single tumefactive lesion common
Often incomplete, “horseshoe-shaped” enhancement, open toward cortex
Gliomatosis Cerebri
T2 hyperintense infiltrating mass with enlargement of involved structures
May cross CC
Typically nonenhancing at presentation
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