Depressive Disorders


6


DEPRESSIVE DISORDERS


DISRUPTIVE MOOD DYSREGULATION DISORDER


Clinical Description


Disruptive mood dysregulation disorder (DMDD) was introduced in DSM-5 (American Psychiatric Association 2013) in order to provide a diagnostic home for a group of children and adolescents who were formerly being diagnosed with pediatric or “broad phenotype” bipolar disorder. The diagnosis of DMDD arose out of research on a subgroup of children with “severe mood dysregulation” (SMD), a syndrome characterized by severe, nonepisodic, chronic irritability and many of the hyperarousal symptoms of mania without the discrete, episodic nature of mania or hypomania. Unlike youth with narrow-phenotype or classic bipolar disorder, youth with SMD had high rates of comorbid attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and anxiety disorders; did not have mood episodes; had lower familial rates of bipolar disorder; and demonstrated a different neurocognitive and neuroanatomic profile. Longitudinal follow-up of individuals with SMD to adulthood demonstrated an increased risk of developing depressive and anxiety disorders but not bipolar disorder (Leibenluft 2011).


The diagnosis of DMDD requires the presence of at least a 12-month period of persistently irritable or angry mood punctuated by severe, recurrent temper outbursts of physical and/or verbal aggression that are excessive for the situation or provocation, in at least two settings (not only at home). The outbursts must be developmentally inappropriate and occur at least three times per week (on average). There cannot be a period of 3 or more consecutive months during the 12 months in which the diagnostic symptom criteria were not met. The diagnosis cannot be initially made before age 6 years or after age 18 years, and the onset of symptoms must be before age 10 years. The angry mood and dysregulated behavior of children with DMDD impair home, school, and social life. If intermittent explosive disorder or bipolar disorder is present or if full symptom criteria for a hypomanic or manic episode (with the exception of duration) are met for more than a day, DMDD cannot be diagnosed. If a child’s symptoms meet criteria for both ODD and DMDD, he or she should be diagnosed only with DMDD. DMDD and ADHD can be diagnosed simultaneously if criteria for both are met.


Given the significant clinical overlap and comorbidity with other psychiatric disorders (especially ODD, conduct disorder, and depressive disorders), more studies are required to establish the distinct phenomenology of DMDD.


Epidemiology and Comorbidity


Reported prevalence rates vary widely, with low rates in community samples and significantly higher rates in clinic settings and in younger children. An analysis of two large community samples of children ages 9–17 years (Great Smoky Mountains Study of Youth and Caring for Children in the Community) yielded a prevalence rate of DMDD of approximately 1% (Copeland et al. 2013), with a cumulative prevalence of 4.4%. Comorbidity with ODD, conduct disorder, and depressive disorders was substantial. When the age at onset criterion was disregarded, the prevalence rate in a preschool community cohort (ages 2–5 years) was higher (3.3%) (Copeland et al. 2013). In a different general population sample (ages 6–12 years, N=665), the prevalence of DMDD was 9%. Of the 9%, 92% had symptoms that met criteria for ODD, whereas only 66% of children with ODD had symptoms that met criteria for DMDD (Mayes et al. 2016).



DMDD rates in an outpatient clinical sample of 706 youth (ages 6–12) enrolled in the Longitudinal Assessment of Manic Symptoms (LAMS) study were 26% at intake and a cumulative 40% by the end of 2 years. DMDD had low diagnostic stability, with 52% of those who qualified for a diagnosis of DMDD meeting criteria at only one assessment during the 2-year study. DMDD overlapped significantly with ODD and conduct disorder, and was not associated with current, new onset, or parental history of mood or anxiety disorders (Axelson et al. 2012). In a community mental health clinic sample, the prevalence rate of DMDD was found to be 31%, with high rates of comorbidity with ODD (96%), conduct disorder (24%), and ADHD (81%) (Freeman et al. 2016).


The significant overlap between DMDD and ODD has raised concerns about the diagnostic validity and utility of the DMDD construct and has led some to argue that it should be an ODD specifier rather than a separate DSM diagnosis (Mayes et al. 2016).


Etiology


As DMDD is a new diagnosis, little is known about its etiology. A family history of bipolar disorder may increase the risk of DMDD (Sparks et al. 2014).


Course and Prognosis


Young adults who retrospectively met criteria for DMDD in childhood had higher rates of anxiety, depression, and other psychiatric illness; poorer health; lower socioeconomic status; more criminal problems; and lower overall functioning in adulthood than individuals who did not qualify for the diagnosis in childhood (Copeland et al. 2014).


Evaluation and Differential Diagnosis


It is important to obtain parent and teacher reports to establish the presence of impairment in more than one setting. It may be challenging for parents to recall whether temper outbursts meet duration and frequency criteria for diagnosis. It is important to rule out other disorders that may manifest with irritability and outbursts, such as major depressive disorder, persistent depressive disorder, untreated ADHD, or undiagnosed communication or learning disorders. In addition, in adolescents, it is important to rule out substance or alcohol use disorders, which can present with irritability and angry outbursts. One should obtain a detailed medication history to determine if medication side effects (such as from corticosteroids or stimulant medications) may be causing irritability. The diagnosis of DMDD precludes making a diagnosis of ODD, even if the criteria are met for both diagnoses, since DMDD is considered to be a more severe disorder.


Treatment


Treatment guidelines have not been established for DMDD (Roy et al. 2014). Preliminary data from studies of children with SMD suggest a positive effect of stimulant medications (especially in children with comorbid ADHD and aggression) and of risperidone. Valproate has shown some benefit in treatment of aggression in children with ADHD, ODD, and conduct disorder (Roy et al. 2014). More recently, an open trial of stimulants in children with both ADHD and DMDD demonstrated good tolerance and clinically significant improvements in ADHD, depressive, and ODD symptoms, although many patients continued to have significant impairment (Baweja et al. 2016).


MAJOR DEPRESSIVE DISORDER AND PERSISTENT DEPRESSIVE DISORDER


Clinical Description


DSM-5 criteria for depressive disorders are the same for children and adults, with a few exceptions (Table 6–1). Persistent depressive disorder (PDD) (also called dysthymia) encompasses the DSM-IV diagnoses of both dysthymic disorder and chronic major depressive disorder (MDD). If the criteria for PDD are met, it can be diagnosed even when full criteria for MDD are also present. Children with PDD present with a history of irritable or sad mood for at least 1 year with at least two of the following: disturbance in appetite, disturbance in sleep, low energy or fatigue, low self-esteem, poor concentration or difficulty making decisions, and hopelessness. On the basis of research, DSM-5 has removed the previous MDD exclusion criterion for recent bereavement.






























TABLE 6–1. Developmental differences in DSM-5 criteria for depressive disorders


Disorder


Adults


Children


Major depression


Depressed mood


Can be irritable mood



Change in weight or appetite


Can be failure to make expected weight gains


Persistent depressive disorder (dysthymia)



Depressed mood


Can be irritable mood


At least 2-year duration


At least 1-year duration


At all ages, depressed mood inferred from observation of the patient (appears sad or tearful) can be substituted for the patient’s report. The anhedonia criterion of diminished interest or pleasure in activities can be met by observed apathy. Children and adolescents often report this as pervasive boredom. Mood-related symptoms may be manifested in different ways at different developmental levels. Key indicators of depression in young people are declining school performance, withdrawal from social activities, somatic symptoms (especially headaches and abdominal pain), sleep difficulties, and conduct problems. Consistent neurovegetative symptoms are rare in childhood depression or dysthymia.


Epidemiology


The prevalence of major depression has been estimated at 1%–3% in prepubertal children and 3%–9% in adolescents, although rates vary with the population, the diagnostic criteria, and the methods of assessment. In the Oregon Adolescent Depression Project (Lewinsohn et al. 1994), the lifetime prevalence of at least one episode of major depression by late adolescence was 20%–25%, and the lifetime prevalence of dysthymic disorder was 3%. Many more youth have depressive symptoms than have full major depression or dysthymia. Before puberty, depression is equally common in boys and girls, with a change in adolescence to the female predominance found in adults.


Etiology


Etiological factors for mood disorders in children are similar to those in adults. Depression in a parent is a significant risk factor via both genetic transmission and interpersonal influence (i.e., parent’s modeling, emotional unavailability, decreased capacity for parenting). Abuse and neglect may be significant precipitants, especially in very young children.


Course and Prognosis


Mood disorders in childhood are serious and potentially fatal problems. In a 15-year follow-up of children with major depression, 4% had died by suicide (Wolk and Weissman 1996). A 10- to 15-year follow-up of a clinical sample of subjects with adolescent onset of major depression found that nearly 8% had committed suicide (Weissman et al. 1999). Risk of suicide increases with a past history of suicide attempt, comorbid substance abuse, access to lethal means (such as a gun), impulsivity, conduct disorder, family history of suicide attempts, or physical or sexual abuse. Over the full age range, earlier age at onset implies a lengthier and more severe course and greater genetic loading. Over the past 25 years, the age at onset of major depression appears to have decreased. In a prospective natural history observation study of clinically referred prepubertal children, the median length of the major depressive episode was 9 months. The median length of time for recovery from dysthymia was 4 years. Dysthymia often progressed to a major depressive episode before resolving. Risk for subsequent episodes of major depression or dysthymia is high (Kovacs 1996). In a sample of high school students, episodes of major depression lasted as long as 10 years (mean = 26 weeks; median = 8 weeks). Of those who recovered, one-third had another episode within 4 years. Suicidal ideation was associated with earlier onset, longer episodes, and earlier relapse of depression (Lewinsohn et al. 1994). Follow-up studies of depressed youth consistently find increased risk of repeated mood disorders and other psychiatric disorders, personality disorders, substance abuse, and impairment in subsequent educational and vocational achievement and peer and family relationships.


Childhood-onset depression is more likely than adult-onset depression to evolve into bipolar disorder. Among adolescents with major depression, subsequent bipolar disorder was predicted by precipitous onset of symptoms, psychomotor retardation, psychotic features, psychopharmacologically precipitated hypomania, and family history of bipolar disorder (Strober and Carlson 1982).


Evaluation and Differential Diagnosis


The clinician should ask children direct questions about depression. Young children have more difficulty recognizing and verbalizing their feelings and may use idiosyncratic words to describe dysphoria or anhedonia. Both parent and child reports are essential. Some children report their mood states more accurately than their parents can, although young children may have limited insight into other symptoms. A trained clinician should observe children for depressed affect. The Children’s Depression Inventory (CDI; Kovacs 1985) may be a useful self-report screening instrument.


Assessment of the degree of potentially dangerous behavior is crucial. The clinician can question children directly regarding suicidal ideation, suicide plans, and suicide attempts. No evidence indicates that inquiries about wishes or attempts to die increase the risk of self-destructive behavior. Substance abuse increases the risk of suicide. The clinician should ask specifically about emotional or physical abuse or neglect of the child, access to lethal weapons, family members or friends who have attempted suicide, nonsuicidal self-injury, prior suicide attempts, and any potential protective factors (relationships or spiritual beliefs).


Even in nonclinical epidemiological samples, anxiety disorders, ADHD, and disruptive behavior disorders frequently coexist with depression and dysthymia, with onset before or after the onset of the mood disorder. Alcohol or drug abuse may cause a secondary depression or may represent an attempt to “self-medicate” dysphoria. Diagnosis of a mood disorder may be impossible without observing the patient in a drug-free state. Separation anxiety disorder may resemble major depression or dysthymic disorder or may coexist with it. Children younger than 4 years may develop a clinical picture similar to major depression when separated from their parents. Children with reactive attachment disorder secondary to parental abuse or neglect who present with lethargy, apathy, and withdrawal may appear depressed.


The strong family clustering of mood disorders suggests that parents and siblings should be evaluated routinely for mood and anxiety disorders, and treatment should be provided or arranged as necessary.


Treatment


If risk-taking behavior or suicidal ideation is present, close parental and psychiatric supervision is needed. Psychiatric hospitalization may be required for youngsters who are psychotic or seriously suicidal or who do not respond to outpatient treatment.


Up to 60% of patients with mild to moderate depression respond to supportive treatment. However, early-onset mood disorders often have devastating effects on development. Long-term treatment is often needed. Even after spontaneous remission or successful treatment, reduced coping skills, cognitive patterns associated with depression, and impaired interpersonal relationships with peers and family members may require individual, group, or family therapy to address developmental deficits or sequelae of the depression. Whatever the treatment, involvement of the family is even more crucial than for adult patients. Both patients and families benefit from psychoeducation (provision of information about the disorder and its treatment) (see Appendix, “Resources for Parents”) and from instruction in relapse prevention (taking medication as prescribed, recognizing early symptoms of relapse, and avoiding precipitants of relapse such as sleep deprivation and drug abuse).


For nonpsychotic depression, psychotherapy is typically the first treatment. Medication is added if symptoms do not improve in 4–6 weeks (see Chapter 17, “Psychopharmacology”). For more severe depression, medication is indicated as initial treatment. Fluoxetine (age 8 years and older) and escitalopram (age 12 years and older) are currently approved by the U.S. Food and Drug Administration (FDA) for the treatment of pediatric major depressive disorder.


Cognitive-behavioral therapy (CBT) and interpersonal therapy (IPT) techniques developed for the treatment of depression in adults have been adapted for use in children and adolescents (Mufson et al. 2004) (see also “Additional Reading”). Social withdrawal and limited peer relationships may respond to behavioral activation and social skills training. Remedial education or tutoring may be needed when the illness has interfered with learning in school.


For adolescent depression, a National Institute of Mental Health (NIMH)–funded multisite study (Treatment for Adolescents With Depression Study Team 2003) compared randomized assignment to fluoxetine, CBT, the combination, or placebo in 439 adolescents with MDD. Summary findings were that on the Child Depression Rating Scale, fluoxetine (with or without CBT) was superior to placebo in efficacy with an acceptable risk-benefit profile, and that at week 12 of treatment, combined treatment and fluoxetine alone were equal in benefit and had greater benefit than CBT, which was not significantly different from placebo (March et al. 2004). Response was faster with combined treatment than with CBT alone, but the results of all active treatments converged by 18 weeks (Kennard et al. 2009). Further analysis showed (somewhat counterintuitively) that combined treatment had an advantage over fluoxetine alone for mild to moderate depression but no significant advantage for moderate to severe depression.


The subsequent NIMH-funded six-site Treatment of Resistant Depression in Adolescents (TORDIA) study included 334 adolescents with MDD or dysthymia who had not responded to an adequate trial of a selective serotonin reuptake inhibitor (SSRI) for at least 8 weeks. Subjects were randomly assigned to one of four conditions: switch to a different SSRI (predominantly citalopram) or to venlafaxine or add CBT to either of those medication switches. Adding CBT to either medication switch was more effective than a medication switch alone. There was no difference in efficacy between switch to another SSRI or venlafaxine, but venlafaxine produced more side effects (Brent et al. 2008). The initial trajectory by 6 weeks of treatment predicted whether the patient would remit, suggesting that clinicians should not wait longer than 6–8 weeks to switch or add treatments if the patient is not responding.


Even with evidence-based treatments, many youth remain impaired and vulnerable to relapse. Research is ongoing to find strategies to improve remission rate and reduce or delay relapses. For severe (especially if psychotic) adolescent depression unresponsive to adequate trials of pharmacotherapy, electroconvulsive therapy may be considered, although there are no research studies in adolescents. Transcranial magnetic stimulation appears to be useful in depressed adults, but there is no completed controlled study in adolescents.


Children and adolescents who have seasonal affective disorder may respond to morning treatment with bright white light (Swedo et al. 1997).


REFERENCES


American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. Arlington, VA, American Psychiatric Association, 2013


Axelson D, Findling RL, Fristad MA, et al: Examining the proposed disruptive mood dysregulation disorder diagnosis in children in the Longitudinal Assessment of Manic Symptoms study. J Clin Psychiatry 73(10):1342–1350, 2012 23140653



Baweja R, Belin PJ, Humphrey HH, et al: The effectiveness and tolerability of central nervous stimulants in school-age children with attention-deficit/hyperactivity disorder and disruptive mood dysregulation disorder across home and school. J Child Adolesc Psychopharmacol 26(2):154–163, 2016 26771437


Brent D, Emslie G, Clarke G, et al: Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial. JAMA 299(8):901–913, 2008 18314433


Copeland WE, Angold A, Costello EJ, Egger H: Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dysregulation disorder. Am J Psychiatry 170(2):173–179, 2013 23377638


Copeland WE, Shanahan L, Egger H, et al: Adult diagnostic and functional outcomes of DSM-5 disruptive mood dysregulation disorder. Am J Psychiatry 171(6):668–674, 2014 24781389


Freeman AJ, Youngstrom EA, Youngstrom JK, Findling RL: Disruptive mood dysregulation disorder in a community mental health clinic: prevalence, comorbidity and correlates. J Child Adolesc Psychopharmacol 26(2):123–130, 2016 26745325


Kennard BD, Silva SG, Tonev S, et al: Remission and recovery in the Treatment for Adolescents with Depression Study (TADS): acute and long-term outcomes. J Am Acad Child Adolesc Psychiatry 48(2):186–195, 2009 19127172


Kovacs M: The Children’s Depression, Inventory (CDI). Psychopharmacol Bull 21(4):995–998, 1985 4089116


Kovacs M: The course of childhood-onset depressive disorders. Psychiatr Ann 26:326–330, 1996


Leibenluft E: Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths. Am J Psychiatry 168(2):129–142, 2011 21123313


Lewinsohn PM, Clarke GN, Seeley JR, Rohde P: Major depression in community adolescents: age at onset, episode duration, and time to recurrence. J Am Acad Child Adolesc Psychiatry 33(6):809–818, 1994 7598758


March J, Silva S, Petrycki S, et al; Treatment for Adolescents With Depression Study (TADS) Team: Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trial. JAMA 292(7):807–820, 2004 15315995



Mayes SD, Waxmonsky JD, Calhoun SL, Bixler EO: Disruptive mood dysregulation symptoms and association with oppositional defiant and other disorders in a general population child sample. J Child Adolesc Psychopharmacol 26(2):101–106, 2016 26745442


Mufson L, Dorta KP, Wickramaratne P, et al: A randomized effectiveness trial of interpersonal psychotherapy for depressed adolescents. Arch Gen Psychiatry 61(6):577–584, 2004 15184237


Roy AK, Lopes V, Klein RG: Disruptive mood dysregulation disorder: a new diagnostic approach to chronic irritability in youth. Am J Psychiatry 171(9):918–924, 2014 25178749


Sparks GM, Axelson DA, Yu H, et al: Disruptive mood dysregulation disorder and chronic irritability in youth at familial risk for bipolar disorder. J Am Acad Child Adolesc Psychiatry 53(4):408–416, 2014 24655650


Strober M, Carlson G: Bipolar illness in adolescents with major depression: clinical, genetic, and psychopharmacologic investigation. Arch Gen Psychiatry 39:549–555, 1982 7092488


Swedo SE, Allen AJ, Glod CA, et al: A controlled trial of light therapy for the treatment of pediatric seasonal affective disorder. J Am Acad Child Adolesc Psychiatry 36(6):816–821, 1997 9183137


Treatment for Adolescents With Depression Study Team: Treatment for Adolescents With Depression Study (TADS): rationale, design, and methods. J Am Acad Child Adolesc Psychiatry 42(5):531–542, 2003 12707557


Weissman MM, Wolk S, Goldstein RB, et al: Depressed adolescents grown up. JAMA 281(18):1707–1713, 1999 10328070


Wolk SI, Weissman MM: Suicidal behavior in depressed children grown up: preliminary results of a longitudinal study. Psychiatr Ann 26:331–335, 1996


ADDITIONAL READING


Birmaher B, Brent DA: Depressive and disruptive mood dysregulation disorders, in Dulcan’s Textbook of Child and Adolescent Psychiatry, 2nd Edition. Edited by Dulcan MK. Arlington, VA, American Psychiatric Association Publishing, 2016, pp 245–276


Friedberg RD, McClure JM: Clinical Practice of Cognitive Therapy With Children and Adolescents: The Nuts and Bolts, 2nd Edition. New York, Guilford, 2015



Kennard BD, Hughes JL, Foxwell AA: CBT for Depression in Children and Adolescents: A Guide to Relapse Prevention. New York, Guilford, 2016


Mufson L, Dorta KP, Moreau D, Weissman MM: Interpersonal Psychotherapy for Depressed Adolescents, 2nd Edition. New York, Guilford, 2004

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Nov 25, 2018 | Posted by in PSYCHIATRY | Comments Off on Depressive Disorders
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