Psychological and physical symptoms recur, starting during the time between ovulation and menstruation and ending soon after the onset of menstruation. Psychological symptoms include irritability, anxiety, tension, tiredness and depression. Common physical symptoms and signs of premenstrual syndrome are:

No treatment has been proved to be consistently effective. Those tried include progesterone, the oral contraceptive pill, bromocriptine, pyridoxine (vitamin B₆), diuretics and antidepressants such as selective serotonin reuptake inhibitors (SSRIs). Supportive psychotherapy and relaxation therapy may be as effective as pharmacotherapy.