Level of intervention
Clinical management
Universal
• Promote positive mental health
• All persons with TBI
• Assess hopelessness and SI proactively
• Recognize that persons may be at risk at various times post-injury
• Promote long-term supports
• Monitor males and females equally
Selected
• Provide treatment for emotional disorders and substance abuse
• Persons with TBI at risk for suicide
• Monitor persons with comorbid conditions and persons who sustained TBI as result of suicide attempt
Indicated
• Reduce lethality of environment
• Persons with TBI for whom suicide is an identified issue
• Provide treatment for emotional disorders and substance abuse
• For persons with past suicide attempt, be aware that persons may use more than one method
• Conduct full clinical interview, including structured risk assessment
• Monitor for at least 12 months following a suicide attempt
• Provide emergency contact card with crisis numbers
Assessment Considerations
The structured clinical interview remains the gold standard for diagnosing depressive and anxiety disorders in persons with TBI. However, self-report measures are often used to screen for emotional distress and to monitor symptoms over time. Self-report measures are frequently used clinically and in empirical investigations of emotional distress. There are several measures with demonstrated validity as screening measures for depression and anxiety following TBI [28, 62]. These measures include: the Beck Depression Inventory-II [63], the Center for Epidemiological Studies-Depression Scale [64], the Patient Health Questionnaire-9 [65], Neurobehavioral Functioning Inventory-Depression Scale [66], the Depression Anxiety Stress Scales [67, 68], and the Hospital Anxiety and Depression Scale [69].
Self-report measures are best used for ruling out the presence of an emotional disorder [28]. Cook et al. [26] suggest that clinicians utilize an “inclusive” approach to the diagnosis of depression following TBI, where all symptoms are counted toward the diagnosis regardless of possible cause (e.g., TBI or depression), and that clinicians not minimize reported cognitive or somatic symptoms when diagnosing depression in this population. Clinicians should use structured clinical interviews following a positive screen to confirm a suspected diagnosis in persons with TBI. The structured clinical interview is also indicated for the differential diagnosis of patients with TBI who present with complex symptoms and with symptoms that can be attributed to multiple disorders [28]. In cases where clinicians have concerns regarding the impact of impaired awareness on the validity of a patient’s responses, use of specific and concrete questions during the clinical interview is recommended [28].
Interventions
Patients with depression and/or anxiety may receive pharmacological and/or psychological treatment for their emotional distress. Unfortunately, the literature suggests that there are large numbers of persons with clinically significant depression and anxiety who are not receiving treatment [2, 42]. There is insufficient evidence regarding the efficacy of a specific class of medications for the treatment of depression or anxiety following TBI [70, 71]. There is not sufficient evidence to support practice recommendations regarding specific psychological treatments for depression or anxiety [70, 71] of persons with TBI. However, there is a growing body of literature investigating the use of psychological interventions validated in the general population, especially cognitive-behavioral therapy, to treat emotional distress in persons with TBI.
Cognitive-behavioral approaches to the treatment of emotional distress have demonstrated effectiveness in many populations, and appear ideally suited for the TBI population because they offer inherent structure and focus. This structure and content can be adapted for use with persons with cognitive deficits [72]. In fact, the majority of psychological interventions for emotional distress following TBI described in the extant literature are cognitive-behavioral interventions that have been modified for use with persons with cognitive deficits following injury [73–76] or include cognitive-behavioral components [77]. Results of these studies suggest that the use of adapted cognitive and behavioral interventions may improve emotional functioning following TBI. However, there are several limitations to these findings including small sample sizes, lack of control group, mixed etiology of injury, and use of convenience samples that may not be experiencing significant levels of emotional distress. Some studies excluded persons with more severe cognitive deficits, resulting in improved internal validity, but limited generalizability of findings and prevention of further examination of the impact of cognitive deficits on response to the intervention.
Persons who sustain a TBI, especially a moderate or severe TBI, often experience cognitive deficits that could have a negative impact on their ability to benefit from standard psychological treatments. For example, poor attention and memory could impact learning and recall of session content. Decreased initiation could impact perceived compliance with treatment. Problem-solving deficits could impact completion of homework assignments. Thus, psychological interventions for the treatment of depression and anxiety following TBI should take such deficits into account and be adapted to fit the needs of the individual client. Incorporating cognitive rehabilitation techniques into psychotherapeutic interventions may be important for maximizing response to psychological treatments for emotional distress following brain injury [78].
Reported adaptations to the structure and content of cognitive-behavioral interventions are listed in Table 2. These and other adaptations have also been applied in a recent pilot study of a mindfulness-based stress reduction program for reducing depression in persons with mild TBI and post-concussion syndrome [79]. Findings to date suggest that persons with cognitive deficits can participate in and benefit from these adapted interventions [73, 74, 76].
Table 2
Adaptations to cognitive-behavioral interventions
• Provision of supplementary written materials | • Built-in repetition and review of key concepts |
• Focus on concrete goals | • Providing “extra time” for sessions |
• Provision of session summary notes | • Providing within-session breaks |
• Limiting the amount of text on worksheets | • Use of larger font size |
• Limiting size of group | • Using visual aids and checklists |
• Providing multiple choice options on worksheets | • Reducing emphasis on self-directed, higher level reasoning skills |
It is also important to note that psychological treatment of emotional distress is a key component of comprehensive cognitive rehabilitation programs, and there is evidence that participation in these programs is associated with improved outcomes, including community integration, life satisfaction, emotional functioning, and self-efficacy [80, 81]. However, the impact of program components that are specific to the treatment of emotional distress is unknown at this time.
The importance of developing and maintaining a meaningful life following TBI is often an important part of psychotherapy following TBI [82]. Ruff [83] describes some of the unique issues faced by psychotherapy clients with TBI due to the nature of their injury-related deficits and their effects on multiple life areas, including social relationships, vocational functioning, and financial status. Ruff suggests specific topic areas to explore when helping clients to re-establish meaning following TBI. These include identifying expectations for the anticipated future prior to injury, understanding how the TBI has altered the client’s life and introduced functional limitations, grieving the loss of the anticipated future, and developing a realistic and meaningful future that involves living in accordance with one’s core values. Given the relationship of functional limitations to depression, addressing functional limitations may be of considerable importance for improving and maintaining emotional well-being. Pagulayan et al. [23] suggest that addressing functional limitations may be an important part of treatment for depression in persons with TBI. Finally, consideration of individual preferences regarding treatment types is also important since comfort with and acceptance of treatment type may impact participation and adherence. Fann et al. [84] conducted a telephone survey of 145 persons with mild to severe TBI to explore preference regarding different treatments for depression. Physical exercise and counseling were preferred over other types of treatment including antidepressants, self-help materials, and group therapy or support groups.
There is a strong need for more research in psychotherapeutic interventions for emotional distress following TBI. Specifically, future studies should include larger samples, utilize measures validated for the diagnosis of emotional distress in the TBI population, include an appropriate control condition as well as measures of treatment fidelity, and include long-term follow-up assessments. Investigation of cognitive and psychosocial factors that may impact response to treatment is also warranted so that patients may be “matched” with the treatment most appropriate for them. Examination of interventions validated in other populations, such as behavioral activation approaches, may also be beneficial. Development and evaluation of interventions that target the needs of persons with dual substance abuse and mood disorder diagnoses following TBI is important given the unique needs of this population. Finally, efforts aimed at preventing depressive and anxiety disorders and maintaining emotional well-being over time can have significant and positive impacts on persons with TBI.
Case Studies
The following case studies present different psychological approaches to treating emotional distress in persons who have experienced a TBI, and discuss factors that can inform treatment planning. Case 1 is an example of the treatment of emotional distress in a traditional outpatient setting. Case 2 is an example of the treatment of emotional distress within an interdisciplinary rehabilitation setting, and illustrates how other behavioral interventions can have an impact on emotional functioning following TBI. These examples also highlight how cognitive rehabilitation techniques can be incorporated into psychological interventions for emotional distress.
Case 1
A 39-year-old woman who experienced a moderate TBI at the age of 22 presented for neuropsychological evaluation with complaints of attention problems and anxiety. There was no other significant medical history. The patient graduated from high school and was employed full-time in a call center. She was the single mother of an 11-year-old boy. During the clinical interview, the patient described feeling overwhelmed at work following a recent promotion and uncertain of her ability to handle new job responsibilities. Her son is enrolled in gifted classes at his middle school, and she stated she was “not smart enough since my injury” to help her son with his increasingly difficult homework or to communicate with his teachers. She reported feeling “sick to my stomach” at a recent back-to-school night as the teachers reviewed upcoming student projects. Neuropsychological evaluation revealed mild impairments in information processing speed and variable performance on measures of attention, verbal learning, and memory. Performance on other cognitive measures was within normal limits. Responses to self-report measures of emotional functioning revealed moderate to severe anxiety and mild depressive symptoms. The patient was referred for psychological treatment for anxiety and depression.
The results of the neuropsychological evaluation suggested that this patient would be a good candidate for a psychological intervention that included components of CBT, and her treatment plan was developed in accordance with this model. The patient expressed good understanding of this therapeutic approach and was able to identify thoughts with minimal prompting. She was an active and engaged participant during treatment sessions; however, she demonstrated very poor completion of assigned homework. Discussion of this homework issue revealed that the patient misplaced her homework on some occasions and, at other times, did not remember it until she was on the way to her appointment. Thus, this failure to complete the homework reflected a memory problem rather than noncompliance with the treatment plan. The therapist applied a structured problem-solving approach to the discussion of potential compensatory strategies she could use to help remember her homework, including the use of a memory station, memory notebook, smartphone, and checklists. The patient expressed a strong preference for use of her smartphone applications to help remember homework, and to have electronic versions of the homework that she could access easily. The patient, in collaboration with the therapist, developed a compensatory strategy centered around her smartphone to help her remember her homework. This strategy became quite successful following some initial refinement of the components. The patient’s role in developing this strategy and successfully managing this memory problem was also used as evidence to counter her belief that she was “not smart enough” since her injury.
Case 2
A 19-year-old male who experienced a severe TBI at the age of 7 was referred to a post-acute brain injury rehabilitation program for vocational services. Neuropsychological evaluation showed impairments in multiple domains including attention, learning, memory, executive functions, and processing speed, as well as clinically significant depressive symptoms. Clinical interview revealed that the patient had some acquaintances, but no close friends; he socialized exclusively with family. Notable social communication deficits were observed including poor eye contact, the telling of moderately offensive jokes, frequent interruptions characterized by off-topic comments. The examiner noted that the client frequently acted younger than his age. His stated goals were to get a job, to obtain his driver’s license, and to have a girlfriend.
In contrast to Case 1, the results of the neuropsychological evaluation described in Case 2 documented several cognitive impairments that would likely impact his ability to benefit from a CBT-based approach, especially impairments in executive functions. Thus, a more behavioral approach to the treatment of his depressive symptoms appeared warranted. The client expressed understanding of, and agreement with, his treatment plan. Further assessment revealed that the client enjoyed outdoor activities such as playing sports and walking with his dog. The client and therapist developed a schedule of regular meaningful activities and investigated community-based recreational sports programs which led to his registration in a local judo class. Initially, he had some difficulty following his activity schedule. He reported that he could not remember what he was supposed to do first. Family also reported that he would confuse the order of the steps or get distracted by another activity and fail to return to the task. The therapist helped the client to develop checklists that contributed to improved completion of the tasks. Also, family decided to start paying client for completing household chores, including simple yard work and laundry, to reward successful task completion. Participation in meaningful activities and task completion improved. This was associated with improvements in depressive symptoms. The patient also participated in a social skills intervention group to address his social communication problems. Strengthening social skills can contribute to improved relationships with others, and thus increase perceived social support, which also plays an important role in the experience of emotional distress.
Acknowledgments
Preparation of this chapter was partially supported by the U.S. Department of Education National Institute on Disability and Rehabilitation Research (NIDRR) grants H133G070222, H133A070043, H133B090023, and H133A120020.
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