15 Drug interactions – 2
| T | F | |
|---|---|---|
| 1. Diclofenac does not increase serum lithium levels. |  |  |
| 2. Clinically important interactions occur between diazepam and orphenadrine. |  |  |
| 3. Drug interactions may occur at protein binding sites in the plasma. |  |  |
| 4. Doxazosin can be used safely with reboxetine. |  |  |
| 5. An interaction between disulfiram and warfarin occurs in the liver. |  |  |
| 6. Enalapril increases lithium levels. |  |  |
| 7. Fluoxetine increases lithium levels. |  |  |
| 8. Drug interactions do not occur in the gastrointestinal tract. |  |  |
| 9. Together with lithium, haloperidol should not be given at doses higher than 20 mg daily. |  |  |
| 10. Patients taking MAOIs should avoid pickled herring. |  |  |
| 11. Ibuprofen may reduce lithium levels. |  |  |
| 12. Imipramine is incompatible with tyramine rich foodstuffs. |  |  |
| 13. Drug interactions do not occur in the kidney. |  |  |
| 14. Muscle relaxants interact with MAOIs. |  |  |
| 15. Mixing drugs in syringes can cause drug interactions. |  |  |
| 16. Interaction by mixing drugs in a syringe is an example of pharmacodynamic drug interaction. |  |  |
| 17. MAOIs may interact significantly with TCAs. |  |  |
| 18. Methadone may interact significantly with TCAs. |  |  |
| 19. TCAs potentiate the pressor effects of noradrenaline. |  |  |
| 20. Valproate impairs the efficacy of oral contraceptive drugs. |  |  |
| 21. Decreased intestinal absorption of drugs, caused by the anticholinergic effect of amitriptyline, is an example of pharmacodynamic drug interaction. |  |  |
| 22. Induction of liver microsomal enzymes is an example of pharmacodynamic drug interaction. |  |  |
| 23. Clinically important interactions occur between phenobarbitone and oral contraceptives. |  |  |
| 24. Fluoxetine increases the serum levels of TCAs. |  |  |
| 25. St John’s wort increases the levels of warfarin. |  |  |
