DSM-5: A Bioethical Overview


Year

International classification of diseases (Europe—WHO)

Diagnostic and statistical manual of mental disorders (USA—APA)

1900

ICD-1a
 
1910

ICD-2a
 
1920

ICD-3a
 
1029

ICD-4a
 
1938

ICD-5a
 
1948

ICD-6
 
1952
 
DSM-I

1955

ICD-7
 
1967

ICD-8
 
1968
 
DSM-II

1975

ICD-9
 
1978

ICD-9—CM
 
1980
 
DSM-III

1987
 
DSM-IIIR

1992

ICD-10
 
1994
 
DSM-IV

1996

ICD-10 (children)
 
1998
 
DSM-IV-R

2000
  
2013
 
DSM-5


aClassification of diseases with organic base only

WHO World Health Organization, APA American Psychiatric Association, ICD International Classification of Diseases

Adapted from Del Barrio V. Roots and evolution of the DSM. Hist Psychol. 2009;30(2–3):81–7 [1]. With permission from the University of Valencia





DSM-5


The presentation of the new version of the DSM-5 during the annual meeting of the American Psychiatric Association, in San Francisco, California, in May of 2013 was preceded by a strong controversy, where not only the scientific community intervened but also the printed and digital media. Through these media, the general public also witnessed an unprecedented situation in the development of psychiatry: just as participation of the scientific community had been paradigmatic in the DSM-IV, for the DSM-5 an attempt was made for the diffusion of the broadest spectrum, taking advantage of the resources offered by the globalization in information technology subjects. Not only common people were being informed, but they also had the opportunity to express their points of view through social media, web sites of specialized publications and of digital newspapers or magazines.

Despite the aforementioned, not all information was disclosed and many points remained in the shadows that put into question the way in which the process of creating the manual was carried out. In addition to the positive aspects of the fifth version of the DSM, diverse opinions regarding the limitations of the instrument, roughly illustrated, were being made public.

In order to understand these reactions and weigh them, it is necessary to describe some characteristics of the works that preceded the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, considered by some as an example that represents the latest in scientific thinking, both in content and organization criterion, as well as in the structure of the mental disorders.

The process of reviewing and updating the manual began 1 year after the appearance of the DSM-IVR. From 1999 to 2007, the necessary material was collected and the research was designed that would support the new version. Thirteen teams were formed with a total of more than 400 psychiatrists. Twenty diagnostic groups and six study groups in which 1,200 psychiatrists from six subspecialties and 4,000 doctors from six medical specialties took part. The total cost of the project rose to $25 million dollars.

A pilot test was conducted in 2010 and the proposals of the teams were reviewed.

In the following year proposals related to the criteria, the proposed diagnostic spectra, and the dimensional measures were revised. In 2012, the final draft of the text was prepared and following several revisions, was approved in May 2013 [3].


Objectives


One of the intentions of the project was without a doubt to confirm the scientific nature of psychiatry. The deployment of evidence-based medicine in the last two decades of the last century, hypertrophied up to a point, and the desire to provide empirical evidence available to Psychiatry of the XXI century, were powerful engines to warrant revision of the DSM.

The appearance of the biomarkers was promising for the task of deconstructing the classification of mental disorders. The moment had arrived to open up to and to start taking into account the scientific advances of other specialties: genetics, neuropharmacology, neuroimaging, neuropsychology, epidemiology, epistemology, postmortem research, psychopathology, cognitive psychology, etc.

Among the objectives of the review, reconsidering the relationship between the DSM classifications and research was also included. If psychiatry was to be provided with a firmer scientific basis, then it was essential to rely more on research.

The Neo-Kraepelinian model, basic for the previous DSMs, needed to be reconsidered or at least explore some basic changes [4]. This involved approaching a current medical model from a categorical perspective to a more dimensional point of view, also seeking greater specificity. Taking into consideration the preparation of the ICD-11, a homogenization was attempted with the ICD-10.


Tools


One of the tools used was the study of diagnostic categories over the dimensional diagnosis, supported by a multiaxial system, to the dimensional diagnosis: it went from only using two possible values (present or absent) to using three or more ordinal values.

In this new approach on how to make the diagnoses, it was necessary to take into account an assessment of disorders throughout life; the reality of the transculturality; the links between psychiatry and general medicine; the variations in the processes of psychophysical deterioration and the growing incidence of disabilities; and the use of instruments for the diagnostic evaluation.

Since the previous versions of the DSM, the gender perspective has been increasingly present. One cannot deny that the role of women as psychiatric patients has had certain special connotations, not only as a historical subject but also as an analytical category, which has made it possible that gender perspective be present in psychiatry [5, 6]. The ideological tendency is much more marked in the DSM-5, as will be discussed later.

The disorders contained in the DSM-5 are classified in the following dimensions: substance use disorders, mood disorders, psychotic disorders, anxiety disorders, childhood disorders, and personality disorders.


Developments


Several new elements that can be seen in the DSM-5:

The multiaxial system disappears and is replaced by the dimensional system.

Greater attention to the role of cultural differences in the appearance and development of the disorders, using a phenomenological approach that is underlying the whole design of the manual, taking distances from the exclusion of phenomenology, is present in both the DSM-III and the DSM-IV [7].

A different model was used in the field studies to find a greater diagnostic reliability and an increased acceptability of the manual. In order to minimize the bias resulting from the evaluation of several observers, it was decided to find a coefficient of interreliability using the kappa coefficient and give these studies a greater credibility backed up by the concordance of the evaluators of mental disorders.

Another contribution, in terms of methodology, was the meta-structure approach through clusters: the analysis of different mental commitments in various pathologies, such as reviewing the neurocognitive commitment both in patients with bipolar disorder as well as in individuals suffering from schizophrenia. The clusters used were neurocognitive, neurodevelopment, psychosis, emotional and externalization.

Some of the major changes contained in the DSM-5 are in the field of disorders related to moods, neurodevelopment, child psychiatry, personality disorders, neurocognitive disorders, sexual disorders or affective disorders, and the use of cultural formulation interviews.

The organizational structure of the new manual is similar to DSM-IV and is summarized in Table 6.2. [8].


Table 6.2
Structure of DSM-5 [8]




































Neurodevelopmental disorders

Spectrum of schizophrenia and other psychotic disorders

Bipolar disorders and related disorders

Depressive disorders

Anxiety disorders

Obsessive–compulsive disorders and related disorders

Trauma or stress-related disorders

Dissociative disorders

Somatic symptoms and related disorders

Eating disorders

Elimination disorders

Sleep/Wake cycle disorders

Sexual dysfunctions

Gender dysphoria

Disruptive disorders, impulse control and behavior

Substance use and addictive disorders

Neurocognitive disorders

Personality disorders

Paraphilic disorders

Other disorders
 

Some topics of the DSM-5 have been revised we will discuss their advantages and disadvantages from a bioethical perspective.


Points in Favor of the DSM-5


It would seem that the “rivalry” initiated with the ICD-6 is close to ending. Part of the effort in drafting the DSM-5 was the purpose of finding lines of greater convergence with the future ICD-11 [9], through a rating that holds a certain parallelism and allows an eventual mid-term unification, which goes far beyond the numerical codes. However, not all experts are optimistic about this [10].

The approach has been sought for DSM-5, where research—and the results—are taken into a greater scope, makes it presumably that in this field it has a wider use. This situation could create the low use of the DSM in clinical practice. The correlation between the use of DSM and ICD will be discussed in the Disadvantages section.

The technological advances, which have largely contributed to the emergence, development, and acceleration of globalization, and the effect these developments have had on individuals, society, and culture in general, have also been taken into account in the DSM-5 [11]. The pace of life, which has increased as the twenty-first century advances, is also etiological of pathologies. New disorders caused by these two fronts are opening a space in the new nosological classifications, although this situation has not been without difficulties [12].

Earlier versions of the DSM in Spanish were translations made in Europe, which had more than a few drawbacks derived from the semantic adaptations and the translation of the codes, and the comparison with those of the ICD, in particular the DSM-IV and the ICD-10 [13]. This time, the DSM-5 in Spanish depends directly on the APA, which hired professional translators for both the breviary of the diagnostic criteria of the DSM-5 as well as for the whole manual.

The trend in the versions of the DSM has been to organize groups of criteria which better include the psychopathological characteristics of individuals suffering a mental illness. Some diagnostic criteria contents in the DSM-IVR were, however, too large or were difficult to recall; for example, those of the major depressive disorders [14]. Efforts were made in this sense for the DSM-5, although with only relative success.

It is very positive that the updating of mental disorders has had an inclusive and participatory design [15] as an extension of the impulse on previous work in the DSM precursors. In this sense, the DSM-5 is no worse than the DSM-IV [16].

The presence of field tests, developed in a clinical and academic environment, led by a good number of randomly selected professionals, is one of the predictable guarantees of the manual. In addition, the 11 medical centers chosen to make the protocols in the United States and Canada [17] give reassurance about the results the enormity of this work.

However, there is a concern that cannot be proven: the result of the work of these teams who conducted the field trials depended not so much on their efforts and their personal and professional qualities as the design of the protocols and the previous work on the proposed diagnostic criteria that were proposed: If there were levity in these circumstances, the risks of false positives and negatives would be multiplied (mainly the false positives) and the field trials would shed more distortions than certainties.

Unfortunately, there are indications in this sense: the dates of submission of the findings were postponed more than once, the availability of electronic data is limited, an environment of limited information was experienced, as well as secrecy, concealment, and dissimulation which do not allow sharing the enthusiasm with which the DSM-5 had been received. Some of the issues that are at the basis of this skepticism are described below.

Visit http://​www.​DSM5.​org/​Research/​Pages/​DSM-5FieldTrials.​aspx; when trying to access “To read the studies in AJP in Advance, click on their titles: DSM-5 Field Trials in the United States and Canada, Part I: Study Design, Sampling Strategy, Implementation; DSM-5 Field Trials in the United States and Canada, Part II: Test-Retest Reliability of Selected Categorical Diagnoses and Analytic Approaches; DSM-5 Field Trials in the United States and Canada, Part III: Development and Reliability Testing of a Cross-Cutting Symptom Assessment for DSM-5”, the result is: http://​www.​ajp.​psychiatryonline​.​org/​error404.​aspx?​aspxerrorpath=​/​Errors/​404.​aspx.


Conflictive Issues of the DSM-5


One phenomenon that has attracted the most attention is the presence of Allen Frances at the head of the diehard critics of the DSM-5. Phrases like “Many of the changes included in the DSM-5 are clearly unreliable and scientifically flawed”; “Some of the decisions included in the DSM-5 are not only not supported by scientific evidence but even defy common sense”, in addition to the presentation of a list of the ten errors which—in his opinion—the new manual has [18]. See Table 6.3.


Table 6.3
Top ten errors of the DSM-5 [18]

























Disruptive mood dysregulation disorder with child’s disruptive behavior

Bereavement due to emotional loss as a cause of a major depressive disorder

Minor neurocognitive disorders

Attention deficit disorder in adults

Overeating disorders

Change in the definition of autism

Onset of substance abuse

Addictive behavior

Generalized anxiety disorder

Post-traumatic stress disorder

Pressure from the media was the reason that some of the changes proposed by the teams and some new “pathologies” were not taken into account in the final draft. There is no certainty as to the scientific support that the DSM-5 experts had, not even to include or discard them [18]. See Table 6.4.


Table 6.4
Changes and diagnostic not taken into account in the DSM-5 [18]

















Risk of psychosis

Mix of anxiety and depression

Addiction to the Internet and to sex

Rape as a mental disorder

Hebephilia

Uncomfortable personality

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Apr 20, 2017 | Posted by in PSYCHOLOGY | Comments Off on DSM-5: A Bioethical Overview

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