♦ Preoperative
Operative Planning
- Diagnostic angiography should be performed with specific views that provide excellent visualization of all feeding vessels, nidus, and the venous drainage pattern.
- Rapid frame rates and superselective angiography are frequently required to better delineate the angioarchitecture and hemodynamics of the AVM.
- Rotational angiography may be helpful for small, deep AVMs, particularly those in the posterior fossa and to evaluate associated aneurysms.
- If endovascular cure is not possible, the strategy for embolizing AVMs is to obliterate as many of the feeding vessels as possible to make surgical resection easier and safer. The utility of embolization prior to gamma knife therapy is somewhat controversial.
Special Equipment
- A 6 to 6.5 French (F) sheath
- A 6F guiding catheter
- Flow-directed or over-the-wire microcatheters
- 0.035-inch guide wire and micro–guide wires
- A 5F catheter (for diagnostic angiogram)
- N-butyl-2-cyanoacrylate (NBCA)
- Ethiodized oil
- Tantalum powder
- Five percent dextrose
- Onyx liquid embolic system (ev3 Neurovascular, Irvine, CA)
- Monitored anesthetic care can be used to allow provocative testing prior to embolization of a feeding vessel.
- Some neurointerventionalists perform all AVM embolizations under general anesthesia and do not perform provocative testing, particularly when using the Onxy liquid embolic system, which typically requires prolonged infusion times.
- Occasionally, 30 to 90 seconds of hypotension (systolic blood pressure ~80) is induced at the time of NBCA embolization to allow for maximum control of the glue injection.
- Protamine should be readily available if intraoperative rupture occurs.
Monitoring
- Provocative testing is performed with the use of amobarbital and cardiac lidocaine injections of the feeding vessels through the microcatheter to determine that embolization will not result in a neurologic deficit.
- Somatosensory evoked potentials and motor evoked potentials may be used in the embolization of spinal AVMs.
♦ Intraoperative
Positioning
- The patient is placed in the supine position.
- Intravenous antibiotics, if needed, are given.
- A Foley catheter is placed.
- The proper shielding is placed on the patient.
- Both inguinal areas are shaved and prepped with iodine solution.
- A sterile drape is placed over the prepped areas.
- The head is positioned in neutral position and gently taped in place.
Technique
- Femoral artery puncture is performed and a 6 to 6.5F sheath inserted as described.
- The patient is heparinized and this is maintained throughout the procedure (activated clotting time ~2.5 times baseline). Some endovascular therapists do not use heparin.
- A four-vessel diagnostic angiogram is performed with all views necessary to determine the major vascular branches feeding the AVM and the drainage pattern of each.
- A 6F guiding catheter is inserted through the sheath.
- The guiding catheter is advanced to one of the major parent vessels (e.g., internal carotid artery or vertebral artery) and connected to a continuous heparinized saline flush.
- A microcatheter is steam-shaped to best fit the feeding artery-parent vessel complex.
- A roadmap of the vessels is obtained.
- The microcatheter is navigated into the feeding artery of the AVM just proximal to the nidus but distal to any vessels supplying normal parenchyma; this may require gentle manipulation of the microcatheter with normal saline flushes or with a micro–guide wire.
- A selective angiogram of this branch is obtained and the transit time is evaluated (reflecting the speed of blood flow through the lesion).
- Microcatheter (feeding artery) pressure and simultaneous measurement of systemic arterial pressure can be measured.
- If provocative testing is performed, anesthesia is lightened: baseline neurologic function prior to and after amobarbital and lidocaine are injected through the microcatheter; if there is no change in neurologic function, the vessel can be embolized at the present site of the microcatheter tip; should deficits occur with testing, the microcatheter is advanced further along the vessel and repeat testing performed.
- If using NBCA, after considering the transit time in the feeding vessel, the NBCA is mixed with ethiodized oil and tantalum powder; by varying the amount of oil and NBCA (10 to 30% NBCA to 90 to 70% ethiodized oil), the experienced interventionalist can vary the setting time of the glue material and deliver the embolic agent in a safe, controlled fashion.
- The microcatheter is flushed with 6 to 9 mL of 5% dextrose (ionic solutions will cause polymerization of the NBCA in the catheter).
- Under subtraction angiography or digital roadmap guidance, the NBCA is injected, usually using the single-column technique (usually between 0.2 to 0.7 mL); the objective is to fill the nidus and obliterate the connection with the feeding vessel without any significant glue entering the draining veins.
- The microcatheter is then rapidly removed during aspiration and inspected for glue residue at the tip or tip fracture.
- A postembolization angiogram is then performed to confirm occlusion of the pedicle, preservation of venous drainage, and that all other vessels remained patent, and to rule out any evidence of bleeding.
- If the Onyx liquid embolic system is used, the Onyx is mixed for at least 20 minutes on an Onyx mixer.
- Only ev3 microcatheters and syringes can be used with Onyx because of dimethyl sulfoxide (DMSO) compatibility and burst pressure issues.
- Flush the catheter with 10 mL of saline then slowly fill the catheter dead space with DMSO.
- Immediately connect a syringe filled with Onyx, point the syringe vertically to create interface, and begin embolizing slowly (less than 0.3 mL/min).
- Continuously monitor embolization under fluoroscopic and roadmap guidance
- Continue embolization to fill nidus without excessive reflux or flow into draining veins. Several pauses (not > 2 minutes) may be required to advance material to desired target.
- Slight syringe aspiration and prolonged gentle traction are often required to remove the microcatheter.
- A postembolization angiogram is then performed to confirm occlusion of the pedicle, preservation of venous drainage, and that all other vessels remained patent, and to rule out any evidence of bleeding.
- In general, only two or three vessels are embolized per session.
- A selective angiogram of this branch is obtained and the transit time is evaluated (reflecting the speed of blood flow through the lesion).
Sheath Removal
- The sheath is removed and a closure device is often used for the femoral artery puncture site.
- Many endovascular therapists reverse the heparin with protamine.
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