Genetic Risk Factors for Suicidal Behavior




Ke L, Qi ZY, Ping Y, Ren CY (2006) Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide. Brain Res 1122(1):24–26. doi:10.​1016/​j.​brainres.​2006.​09.​007 PubMedCrossRef


Keller S, Sarchiapone M, Zarrilli F et al (2010) INcreased bdnf promoter methylation in the wernicke area of suicide subjects. Arch Gen Psychiatry 67(3):258–267. doi:10.​1001/​archgenpsychiatr​y.​2010.​9 PubMedCrossRef


Kia-Keating BM, Glatt SJ, Tsuang MT (2007) Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior. Am J Med Genet Part B Neuropsychiatr Genet 144B(8):1048–1053. doi:10.​1002/​ajmg.​b.​30551 CrossRef


Kim S, Choi K-H, Baykiz AF, Gershenfeld HK (2007a) Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post- mortem prefrontal cortex. BMC Genom 8(1):413. doi:10.​1186/​1471-2164-8-413 CrossRef


Kim Y-K, Lee H-P, Won S-D, Park E-Y, Lee H-Y, Lee B-H, Choi S-H (2007b) Low plasma BDNF is associated with suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry 31(1):78–85. doi:10.​1016/​j.​pnpbp.​2006.​06.​024 PubMedCrossRef


Labonte B, Turecki G (2010) The epigenetics of suicide: explaining the biological effects of early life environmental adversity. Arch Suicide Res Off J Int Acad Suicide Res 14(4):291–310. doi:10.​1080/​13811118.​2010.​524025 CrossRef


Labonté B, Suderman M, Maussion G, Lopez JP, Navarro-Sánchez L, Yerko V, Turecki G (2013) Genome-wide methylation changes in the brains of suicide completers. Am J Psychiatry 170(5):511–520. doi:10.​1176/​appi.​ajp.​2012.​12050627 PubMedCrossRef


Lester D (2002) Twin studies of suicidal behavior. Arch Suicide Res 6(4):383–389. doi:10.​1080/​13811110214530 CrossRef


Leszczyńska-Rodziewicz A, Szczepankiewicz A, Pawlak J, Dmitrzak-Weglarz M, Hauser J (2013) Association, haplotype, and gene-gene interactions of the HPA axis genes with suicidal behaviour in affective disorders. Sci World J 207361. doi:10.​1155/​2013/​207361


Li D, He L (2007) Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry 12(1):47–54. doi:10.​1038/​sj.​mp.​4001890 PubMedCrossRef


Linkowski P, de Maertelaer V, Mendlewicz J (1985) Suicidal behaviour in major depressive illness. Acta Psychiatr Scand 72(3):233–238. doi:10.​1111/​j.​1600-0447.​1985.​tb02600.​x PubMedCrossRef


Linnoila VM, Virkkunen M (1992) Aggression, suicidality, and serotonin. J Clin Psychiatry 53(Suppl):46–51PubMed


Malone KM, Haas GL, Sweeney JA, Mann JJ (1995) Major depression and the risk of attempted suicide. J Affect Disord 34(3):173–185PubMedCrossRef


Mann JJ (1998) The neurobiology of suicide. Nat Med 4(1):25–30PubMedCrossRef


Mann JJ (2003) Neurobiology of suicidal behaviour. Nat Rev Neurosci 4(10):819–828. doi:10.​1038/​nrn1220 PubMedCrossRef


Mann J, Huang Y, Underwood MD et al (2000) A serotonin transporter gene promoter polymorphism (5-httlpr) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 57(8):729–738. doi:10.​1001/​archpsyc.​57.​8.​729 PubMedCrossRef

Mar 16, 2017 | Posted by in NEUROLOGY | Comments Off on Genetic Risk Factors for Suicidal Behavior

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