Figure 6.1
fMRI studies provide data correlating behavioral dimensions of complicated grief with activity in underlying neurobiological substrates
Evaluation—Clinical Presentation and Diagnosis
Clinical Suggestions—Presentation, Evaluation, and Diagnosis
We can provide clinical suggestions for the assessment and diagnosis of patients suspected of suffering from bereavement-related complications, which we will simply refer to as Complicated Grief (CG). We will start with a clinical case vignette.
Complicated Grief Case Vignette: Grace
Grace is a 71-year-old white woman. Grace is a retired librarian and has 18 years of education.
Complicated Grief (CG) regarding the death of her husband, John, 18 months ago. Grace and John were married for 45 years. They have four children.
CG symptoms endorsed:
Frequent and intense pangs of grief
Thoughts of her own death and wish to never awaken
Intense longing
Feeling distant from others
Feeling that life is empty
Feeling lonely much of the time
Difficulty trusting others
Baseline:
Inventory of Complicated Grief (ICG) score: 48
Quick Inventory of Depressive Symptomatology (QIDS) score: 21
Clinical Global Impression Score-Severity: 6
Intervention:
Complicated grief therapy + citalopram/placebo (up to 60 mg/day) (HEAL trial*) [108]
Post-treatment:
ICG score: 8, QIDS: 10
Grief Improvement = 2; Depression Improvement = 11
6-month follow-up: Stably well, continuing much improved
CG is characterized by excessive avoidance of reminders of the loss, troubling maladaptive rumination about circumstances or consequences of the death, and persistence of intense and impairing acute grief symptoms beyond what is expected according to social and cultural norms [109]. Of course, views on grief differ across cultures, and data are lacking to inform this determination. Shear describes that “CG goes beyond the normal grieving process and leaves loved ones in an immovable stage of hopelessness” [2]. To put it simply, could be years since the loss, but based on the patient’s response, one would think it was yesterday. The differential diagnosis of CG includes normal grief (CG is a severe grief reaction that persists for at least 12 months or 6 months in children; i.e., acute grief become chronic), depressive disorders (CG is characterized by a deep and persistent focus on the loss to the exclusion of anything else), PTSD (preoccupation with the loss and yearning for the deceased are absent in PTSD), and separation anxiety (separation from current attachment figures versus separation from a deceased individual). Delicate and thoughtful clinical judgement should be used when determining who may be suffering from CG. CG diagnosis may be difficult to diagnose in the first several months post-loss [87, 110].
The clinical interview for assessment is of critical importance. Questions about important losses should be part of a standard diagnostic evaluation, especially in the case of older patients, for whom loss is common. The presence of thoughts and behaviors that are indicative of CG should be assessed. Intense grief is not pathological; however, complicating thoughts and behaviors that impede adaptation to the loss should be identified along with grief that is excessively intense and prolonged. Patients are sometimes ashamed of their persistently intense grief, and it is important for clinicians to ask direct questions in a sensitive and empathic way. Because comorbidities are common, the clinical evaluation of a bereaved person should also include screening for other psychiatric and medical disorders. Careful evaluation of suicidal intent and suicide plans should always be a part of the assessment. Patients should be asked about passive suicidal ideation, often exemplified by unusual risk-taking behaviors and/or the neglect of health problems [87].
A valid tool to measure CG is the Inventory of complicated grief (ICG) [1]. CG has been shown to be reliably detected by the ICG and it has been tested for people with intellectual disabilities [111] and validated in other languages [112]. Assessment by the ICG consists of reporting on 5-point scales (0 = “never,” 1 = “rarely,” 2 = “sometimes,” 3 = “often,” 4 = “always”), the frequency of 19 statements about affects, thoughts, and behaviors related to the loss of a loved one. A total score can be calculated by summing the response to all the items [113]. Scores of 30 or greater are considered to be consistent with a syndromal level of CG and warrant further evaluation and clinical intervention. The DSM5 has also recently introduced new CG symptoms (e.g., difficulty in positive reminiscing; maladaptive self-appraisals) that are not assessed by the ICG [77, 114, 115]. The ICG is a good tool for documenting the presence of symptoms and changes over time. The ICG is also useful for educating patients about their symptoms and pinpointing which ones may be the focus of intervention efforts.
Another clinically useful instrument is the Structured Clinical Interview for Complicated Grief (SCI-CG) [113]. The SCI-CG is a structured clinical interview comprising 31 symptom ratings. An optional screening section assesses characteristics related to the death, including relationship to the deceased, cause of death, and time since the death (<6 months, between 6 and 12 months, or >12 months). Each of 31 CG symptom ratings is graded on a 3-point scale (1 = “Not present,” 2 = “Unsure or equivocal,” 3 = “Present”) over the prior month. A total score ranging from 31 to 93 is calculated by summing the scores of these items. The SCI-CG and assessment guidelines are directly available to clinicians and researchers from the website www.complicatedgrief.org.
Clinical Point: Nosology, classification and diagnostic approaches for identifying CG is a topic of ongoing and intense scientific development, needed in order to mainstream optimal diagnostic criteria.
Treatment
Goals of Treating Complicated Grief in Older Adults
Patients experiencing grief symptoms often do not seek professional treatment. When they do present for treatment, a clinician’s main role is supportive. Empathy, compassion, and understanding provide a necessary foundation for clinical expertise [116]. Most individuals with CG are aware that something is wrong, but often do not know what it is. These individuals are often relieved to receive a diagnosis [10, 29], but the avoidance of misdiagnosis and overdiagnosis remains crucial to appropriate clinical management. Physicians can educate, recommend treatment options, and help patients navigate proper support channels.
Pharmacotherapy
Although antidepressants have historically been prescribed to older adults with CG [117–120], the evidence for their efficacy is unclear. Caution should be exercised in prescribing medication for CG. The best evidence available has been provided by a recent large placebo-controlled trial of citalopram for CG [116]. This trial was the first placebo-controlled randomized clinical trial to evaluate the efficacy of antidepressant pharmacotherapy , with and without complicated grief psychotherapy, in the treatment of CG. Citalopram was found to have no efficacy beyond placebo as stand-alone treatment for CG, but suggests that adding citalopram to an effective psychotherapy regiment may alleviate co-occurring depressive symptoms. These results suggest that bereavement-related depression responds just fine to antidepressant pharmacotherapy, while CG requires tailored psychotherapy.
Psychotherapy
After several psychotherapy interventions yielded negative results when using interventions stemming from depression treatment (interpersonal therapy, for example) [121–123], researchers sought out to develop a specific psychotherapy for CG. Some success with cognitive behavioral therapy (CBT) [124] sparked the development of CBT for CG, or Complicated Grief Therapy (CGT). Chapter 13 further reviews the principles and evidence base supporting CBT and CGT for CG.
Briefly, CGT consists of reframing autobiographical narratives regarding the loss. As a form of exposure therapy, individuals are asked to gradually confront avoided aspects of the loss. The therapist challenges negative beliefs and catastrophizing misinterpretations through cognitive restructuring, helps create meaningful and positive associations, and/or helps people to set life-goals and engage in new, meaningful activities [87, 125, 126].
Numerous investigations have demonstrated the effectiveness of CGT [82, 111, 113, 122–131]. For example, CGT was tested in a large-scale RCT with elderly bereaved persons with CG, showing strong reductions in CG symptoms and beneficial effects relative to interpersonal psychotherapy (IPT) post-treatment [121, 122]. In the treatment trial that demonstrated citalopram as inefficacious comparable to placebo in the treatment of CG symptoms, CGT was found to be the treatment of choice for CG [116].
There is promising potential for the use of telemedicine for caring for patients with CG. CGT provided via the internet continues to be established and tested with promising results [128, 129, 132, 133].
Predicting Treatment Response
The best CG treatments only achieve clinically meaningful improvement for roughly 70–80% of patients [114]. There is a need for treatments to be improved. It is still unclear for whom therapies yield the best results, or if specific therapies need to be developed for certain subpopulations based on pre-treatment factors or patient characteristics.
It has been shown that bereaved elders with high suicide ideation show larger reductions in CG symptoms in response to CGT than those with low suicide ideation [135]. This leads to the conclusion that patients who are in worse condition before treatment may have a better response than those who have fewer symptoms. In sum, predicting treatment response in older adults with CG is a topic of great scientific interest and where a great deal of the gaps in our knowledge lies.
Prevention of CG
Given the significant burden associated with CG, there is enormous interest in whether clinicians can encourage resilience after a significant loss through preventive efforts. In a systematic review of nine preventive interventions, researchers concluded that there was inconsistent support for their effectiveness in decreasing CG symptoms [134]. However, this finding does not mean that interventions aimed at preventing CG do not have any value. At the time the review was conducted (2011), there were no published guidelines for CG in the DSM; therefore, studies varied in the way they defined and measured CG (which makes it hard to compare results across studies). This finding also highlights the possibility that prevention studies are more difficult to conduct among older adults. While clinicians may know who is at risk for CG after a significant loss, older adults may perceive their grief symptoms to be “normal” and may not seek help. It is very difficult to connect with older adults who are not treatment seeking.
Preventive interventions for CG can be divided into primary interventions and secondary interventions. Primary preventive interventions are those that are available to all bereaved elders, regardless of whether an intervention is needed. Examples include support group meetings and psychoeducation sponsored by counseling organizations, local churches, or senior centers. Secondary interventions are those that target people who have been identified through screening procedures as exhibiting a risk factor and therefore vulnerable to the mental health effects of bereavement. Risk factors for CG include: a history of mental health problems, heavy caregiving prior to loss, social isolation, dependent attachment style, compromised medical health, low educational attainment, and traumatic circumstances of loss, among others [5, 136].
After we screen and identify older adult who are at risk for CG, how do we intervene and facilitate adaptation to loss? In other words, what is the content of the intervention? Figure 6.2 depicts a conceptual model of the trajectory from bereavement to mental and physical health. A preventive intervention that targets known changes post-death may help promote a healthy adaptation to widowhood. For example, bereavement triggers changes in daily routines associated with physical activity, food preparation and eating, and sleep/wake regularity [137, 138]. Because physical health declines more rapidly in the later years when bereavement is most commonly experienced, bereaved elders may be especially vulnerable to the negative consequences of unhealthy lifestyle practices, such as lack of physical activity, poor nutrition, and lack of sleep. Therefore, an intervention that targets routine health behaviors may help bereaved elders reengaged with constructive activities and promote a health adaptation to widowhood. An intervention development study at the University of Pittsburgh (WELL trial) is currently testing the effects of a lifestyle intervention to promote health and welling following spousal bereavement. This intervention will test whether monitoring physical activity, healthy eating, and good sleep practices (on a tablet, daily for 12 weeks) helps adults establish a routine which in turn promotes resilience to bereavement.
Figure 6.2
Proposed trajectory from bereavement to mental and physical health
Continued identification of effective prevention strategies is important for clinical practice. Whether a lifestyle intervention could prevent incident episodes of CG or clinical depression in at-risk older adults is not clear, given the limited evidence. However, the case can be made that lifestyle modification should at least be considered a favorable option for prevention and future clinical trials are warranted. The field should also seek to understand the relative efficacy of lifestyle modification compared to other prevention strategies like increasing social engagement or psychotherapy.
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