Fig. 1
Developmental milestone, measured by negative geotropism (seconds), 72 h after collagenase infusion; (asterisk) <0.05 compared with sham; (cross) <0.05 compared with GMH (vehicle); SEM standard error of the mean; n = 6/group
Fig. 2
Hemoglobin assay, measured by spectrophotometer, 72 h after collagenase infusion; (asterisk) <0.05 compared with sham; SEM standard error of the mean; n = 4/group
Fig. 3
Evans blue, measured by spectrophotometer, 72 h after collagenase infusion; (asterisk) <0.05 compared with sham; (cross) <0.05 compared with GMH (vehicle); SEM standard error of the mean; n = 4/group
Conclusion
Translational stroke studies, in particular those involving animal modeling, are greatly needed to safely integrate basic preclinical scientific principles ahead of further clinical applications [19–23]. This study showed that intranasal IGF-1 treated animals had improved neurological function and amelioration of BBB permeability, edema, and re-bleeding. Therefore, IGF-1 may eventually be shown to play a part in protective brain signaling following GMH. Our observed protective effect may thus offer new promise for potential novel investigations of treatment targeting this vulnerable patient population.
Acknowledgment
This study was partially supported by the National Institutes of Health grant RO1 NS078755 (Dr. Zhang).
Disclosures
None
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