Image-Guided Radiosurgery for Hypothalamic Hamartomas



Fig. 27.1
Treatment planning of a left sessile HH extending into the interpeduncular cystern near the optic chiasm. This case was treated with frameless image-guided robotic radiosurgery (Cyberknife) delivering 151 beams carrying a total dose of 16 Gy prescribed to the 70 % isodose (Maximum dose: 22.85 Gy)



In conclusion, HH are brain tumors causing a severe epileptic disorder. Conventional surgical resection is an effective treatment for epilepsy and mass effect but carries a high risk of major neurological deficits and complications. SRS provides an efficacious and low-risk non invasive treatment option for small to medium size HH and for post-surgical residuals.



References



Arita K, Ikawa F, Kurisu K, Sumida M, Harada K, Ouzumi T, Monden S, Yoshida J, Nishi Y (1999) The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma. J Neurosurg 91(2):212–220PubMedCrossRef


Arita K, Kurisu K, Iida K, Hanaya R, Akimitsu T, Hibino S, Pant B, Hamasaki M, Shinagawa S (1998) Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case report. J Neurosurg 89:645–648PubMedCrossRef


Craig DW, Itty A, Panganiban C, Szelinger S, Krurer MC, Sekar A, Reiman D, Navarayan V, Stephan DA, Kerrigan JF (2008) Identification of somatic chromosomal abnormalities in hypothalamic hamartoma tissue at the GLI3 locus. Am J Hum Genet 82(10):366–374PubMedCentralPubMedCrossRef


Fenoglio FA, Wu J, Kim DY, Simeone TA, Coons SW, Retake H, Rho JM, Kerrigan JF (2007) Hypothalamic hamartoma: basic mechanism of intrinsic epileptogenesis. Semin Pediatr Neurol 14(2):51–59PubMedCrossRef


Frattali CM, Liow K, Craig GH, Korenman LM, Makhlouf F, Sato S, Biesecker LG, Theodore WH (2001) Cognitive deficits in children with gelastic seizures and hypothalamic hamartoma. Neurology 57(1):43–46PubMedCrossRef


Frazier JL, Godwin CR, Han ES, Jal JI (2009) A review on the managment of epilepsy associated with hyportalamic hamartomas. Childs Nerv Syst 25(4):423–432PubMedCrossRef


Friehs GM, Park MC, Goldman MA, Zerris VA, Norén G, Sampath P (2007) Stereotactic radiosurgery for functional disorders. Neurosurg Focus 23:E3PubMedCrossRef


Maixner W (2006) Hypothalamic hamartoma: clinical neuropathological and surgical aspects. Childs Nerv Syst 22(8):867–873PubMedCrossRef


Ng YT, Rekate HL, Prenger EC, Wang NC, Chung SS, Feiz-Erfan I, Johnsonbaugh RE, Varland MR, Kerrigan JF (2008) Endoscopic resection of hypotalamic hamartoma for refractory symptomatic epilepsy. Neurology 70(17):1543–1548PubMedCrossRef

Mar 17, 2017 | Posted by in NEUROLOGY | Comments Off on Image-Guided Radiosurgery for Hypothalamic Hamartomas

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