Intradural Nerve Sheath Tumors




Indications





  • An intradural extramedullary lesion causing neurologic symptoms, including weakness, sensory deficits, or pain, is an indication for surgery. Early and aggressive surgical resection, with the aim of gross total resection, is associated with the best outcomes.





Contraindications





  • Absolute contraindications include systemic infection or uncorrected coagulopathy. Patients presenting with acute and complete neurologic deficit, patients with extensive comorbidities, and patients with a short life expectancy have relative contraindications.





Contraindications





  • Absolute contraindications include systemic infection or uncorrected coagulopathy. Patients presenting with acute and complete neurologic deficit, patients with extensive comorbidities, and patients with a short life expectancy have relative contraindications.





Planning and positioning





  • The initial assessment of a patient with a suspected intradural nerve sheath tumor begins with a detailed history and physical examination.



  • Magnetic resonance imaging (MRI) with gadolinium contrast agent for lesion localization is essential for planning the surgical approach. Schwannomas are characteristically isointense or hypointense to the spinal cord on T1-weighted images, with cystic areas represented by high T2 signal. Areas of hemorrhage or collagen are seen as low attenuation on T2 sequences. Schwannomas and neurofibromas enhance intensely in a homogeneous or heterogeneous pattern. Patients with neurofibromatosis may have multiple lesions along the entire spinal cord.



  • X-rays may show enlargement of neural foramina, a classic finding associated with these lesions, and associated skeletal deformities.



  • Intraoperative neurophysiologic monitoring with motor evoked potentials (MEPs) is essential when operating on intradural nerve sheath tumors. The anesthetic regimen should be coordinated with the anesthesiologist before the start of the case because many anesthetic agents cause depression of MEPs. Commonly used agents that do not cause a decline in motor potentials include propofol, fentanyl, and etomidate.




    Figure 97-1:


    Preoperative T2 sagittal and axial MRI showing a lumbar intradural nerve sheath lesion, with central T2 hyperintensity representing cystic areas.



    Figure 97-2:


    The patient is turned prone after intubation, and electrodes are placed for neurophysiologic monitoring. For cervical lesions, the patient is pinned in a three-point Mayfield head fixator and positioned prone on two chest rolls. The neck is slightly flexed to aid in surgical exposure. For patients with thoracic or lumbar lesions, prone positioning can be accomplished on a Wilson frame or chest rolls without head fixation. All dependent surfaces (e.g., knees, elbows) are padded to avoid peripheral nerve injury or pressure-related tissue damage.





Procedure





Figure 97-3:


Skin is incised in the midline, and monopolar electrocautery is used to dissect the paraspinal muscles from posterior elements in the subperiosteal plane. Dissection should be carried out with caution at the lateral aspects of the vertebral column to prevent facet capsule disruption, which may result in postoperative instability.



Figure 97-4:


The spinous processes and laminae are exposed, and laminotomies are performed bilaterally with a Kerrison punch. A craniotome is used to detach laminae bilaterally over the area of planned dural exposure. Transection of the rostral and caudal ligamentum flavum and interspinous ligaments allows for removal of posterior elements en bloc. An alternative approach is to use a Leksell rongeur and Kerrison punches to perform laminectomy in a piecemeal fashion. When possible, the facet joints should be preserved to prevent postoperative kyphosis. Certain tumors may require wide lateral exposure, however, necessitating removal of the facet joints. In this case, instrumented fixation may be warranted in an immediate or delayed fashion.

Jun 15, 2019 | Posted by in NEUROSURGERY | Comments Off on Intradural Nerve Sheath Tumors

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