Ischemic Postconditioning (RIPC) After GMH in Rodents

Fig. 1

Water-maze analysis at one month after GMH. Animals were tested using progressive levels, from cued to spatial trials. (*) <0.05 compared with sham; (#) <0.05 compared with vehicle. Data expressed as standard error of mean; n = 10–12/group

Fig. 2

Ventricular area (extent of hydrocephalus) at 1 month after GMH. (*) < 0.05 compared with vehicle. Data expressed as standard error of mean; n = 6–8/group

Fig. 3

Pictographs showing relative cortical thickness and ventricular and overall brain size between groups

Conclusion

Translational stroke studies, in particular animal modeling, are greatly needed to safely integrate basic preclinical scientific principles ahead of clinical application [26–30]. This study, in summary, showed that treatment with RIPC is a safe and noninvasive approach and this animal model demonstrated improved sensorimotor and neuropathological outcomes following GMH in rats. Further studies are needed to evaluate the actual mechanisms of RIPC neuroprotection.

Acknowledgment

This study was partially supported by the National Institutes of Health grant RO1 NS078755 (Dr Zhang).

Disclosures

None

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