Leber Hereditary Optic Neuropathy
Loss of central vision. Maternal inheritance; point mutation in mtDNA. 60% to 90% of patients are men.
Clinical Features
Onset: adolescence or early adult years; progressive painless clouding of central vision: usually begins in one eye, affects both within weeks to months. Visual loss often severe, permanent.
Other features (less common): cardiac conduction abnormalities, mild neurologic abnormalities.Stay updated, free articles. Join our Telegram channel
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