Localized Impairment: Strokes, Brain Injuries, and Brain Tumors
What is the major ocular symptom of carotid insufficiency?
Transient monocular blindness.
What is anosognosia?
A body image disorder in which the patient neglects or fails to recognize part of his or her own body.
Usually takes the form of unilateral neglect.
Caused by a parietal lobe lesion.
The patient tends not to use the contralateral limbs, may deny that there is anything wrong with these limbs, and may even fail to recognize the contralateral limbs.
What are the clinical manifestations of an embolic stroke in the left angular gyrus?
Fluent speech and excellent comprehension.
Unable to name fingers and body parts nor to determine right or left orientation.
Unable to write down thoughts and take notes.
Good reading comprehension.
Unable to do calculations.
What language deficiency is typical in a stroke by occlusion of the anterior branches of the left middle cerebral artery?
Location is the inferior frontal convolution, including the Broca area.
Impaired fluency of spontaneous speech.
Which comorbid disease of AIDS produces cerebral focal lesions?
Toxoplasmosis.
Lymphoma.
What are the clinical features of myasthenia gravis?
Insidious onset. Slowly progressive course.
Diplopia, ptosis, dysarthria, extremity weakness, generalized weakness, dysphagia.
Weakness does not conform to the distribution of any single nerve.
Pupillary responses are not affected. Persistent activity of a muscle group leads to temporarily increased weakness, with restoration of strength after a brief rest.
What are the clinical findings in cases of upper motor neuron lesions?
Weakness, paralysis, spasticity.
Increased tendon reflexes, positive Babinski reflex.
No significant muscle atrophy.
What are the contraindications to the use of tissue plasminogen activator (tPA) for thrombolysis in acute stroke?
Risk of hemorrhage:
Prior intracranial hemorrhage; seizure at the onset of stroke symptoms; stroke or trauma occurring less than 3 months before the presenting stroke; a major surgical procedure within 14 days; gastrointestinal or urinary tract bleeding
within 21 days; systolic blood pressure over 185 mm Hg or diastolic blood pressure over 110 mm Hg; current treatment with warfarin for atrial fibrillation.
within 21 days; systolic blood pressure over 185 mm Hg or diastolic blood pressure over 110 mm Hg; current treatment with warfarin for atrial fibrillation.
To avoid unnecessary treatment:
Do not give tPA if neurologic deficits are improving rapidly and spontaneously; if deficits are mild and isolated; in the presence of hypo- or hyperglycemia (which can cause symptoms mimicking a stroke); when symptoms have begun more than 3 hours before the proposed tPA therapy.
Note: The patient’s initial clinical symptoms (change in consciousness, headache, agitation, etc.) are usually not influential factors in the decision to undertake tPA treatment.
What are the lesion locations and clinical characteristics of aphasia?

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