Lumbar Puncture and Imaging Studies

Chapter 20 Lumbar Puncture and Imaging Studies



Lumbar Puncture


Neurologists often obtain cerebrospinal fluid (CSF) by performing a lumbar puncture (LP) – one of the oldest neurologic tests still employed – under a variety of clinical circumstances. When patients have at least two elements of the relatively common triad of headache, fever, and nuchal rigidity, neurologists usually perform an LP to look for meningitis, subarachnoid hemorrhage, or other inflammatory conditions affecting the central nervous system (CNS). They also perform an LP in cases of dementia attributable to infectious illnesses. In Creutzfeldt–Jakob disease (CJD), the CSF almost always contains 14-3-3 protein; in subacute sclerosing panencephalitis, antimeasles antibodies; in acquired immunodeficiency syndrome (AIDS), retrovirus markers; and other infectious illnesses, such as cryptococcal or tuberculous meningitis, herpes simplex encephalitis, and neurosyphilis, specific antigens or DNA detectable by polymerase chain reaction. In another particularly useful test, neurologists send CSF for the JC virus in patients with AIDS who have a cerebral lesion. If present, the JC virus indicates that the diagnosis is progressive multifocal leukoencephalopathy (PML) (see Fig. 15-10). Moreover, a positive test obviates the need for a brain biopsy. Neurologists also test the CSF of patients suspected of having multiple sclerosis (MS) for oligoclonal bands and myelin basic protein (see Chapter 15). In Alzheimer disease, the CSF contains increased levels of tau protein but decreased levels of β-amyloid and Aβ42 peptide.


Diagnosing neurologic illnesses sometimes rests on abnormalities of the CSF profile, which comprises the CSF color, red and white blood cell count, and concentrations of protein and glucose (Table 20-1). For example, most infectious or inflammatory CNS illnesses cause a CSF pleocytosis (increase in the CSF white blood cell count). In these illnesses, a rise in protein concentration parallels CSF pleocytosis, and, in their hallmark, glucose concentration falls to abnormally low levels. Bacterial meningitis accentuates that profile: CSF pleocytosis is markedly elevated, with a predominance of polymorphonuclear instead of lymphocytic cells, and the glucose concentration can fall to undetectable levels. Cultures of virus, fungus, and Mycobacterium may require 1–3 weeks to identify an organism, but sometimes antigen testing can immediately indicate bacterial and nonbacterial organisms. As an exception to the general observation that infectious and inflammatory conditions produce CSF pleocytosis, in Guillain–Barré syndrome, CSF contains a markedly elevated protein concentration but little or no increase in the white cell content (the “albumino-cytologic disassociation,” see Chapter 5).



Despite the potential contribution of CSF examination, certain circumstances contraindicate an LP. For example, neurologists do not perform one when patients have a sacral decubitus ulcer because the LP needle might drive bacteria into the spinal canal and infect the CSF. In addition, neurologists insert the LP needle only below the first lumbar vertebra, the lower boundary of the spinal cord, to prevent spinal cord injury.


An intracranial mass lesion is one of the most common contraindications to an LP. This prohibition is based on the fear that an LP could suddenly reduce pressure in the spinal canal, allowing the unopposed force of a cerebral mass to lead to transtentorial herniation (see Fig. 19-3). Moreover, a CSF examination would not help in diagnosing most mass lesions because their CSF profiles are not distinctive. Although increased intracranial pressure without an associated mass lesion defines idiopathic increased intracranial hypertension (pseudotumor cerebri, see Chapter 9), in this setting neurologists perform LPs with impunity for diagnosis and occasionally for treatment. Overall, unless neurologists suspect acute bacterial meningitis or subarachnoid hemorrhage, in which case rapid diagnosis is crucial, they usually do not perform an LP or they postpone it until after imaging studies have excluded an intracranial lesion.


Another potential problem with an LP occurs when trauma during the procedure causes blood to mix with the CSF, which may falsely indicate a subarachnoid hemorrhage or other intracranial source. To distinguish blood induced by the procedure, laboratories centrifuge bloody CSF. Xanthochromia (Greek, xanthos yellow + chroma color) in the supernatant means that intracranial bleeding took place several hours before the LP and that the red blood cells gave rise to the yellow pigment. In contrast, a clear supernatant means that the LP gave rise to the blood in the CSF.



Imaging Studies


Although computed tomography (CT) and magnetic resonance imaging (MRI) should not enslave physicians, they undeniably provide extraordinarily accurate diagnoses. Each technique has given clinical neurology a quantum leap forward. In fact, Drs. Allan M. Cormack and Godfrey N. Hounsfield garnered Nobel prizes in 1979 for the development of CT, and Dr. Paul C. Lauterbur and Sir Peter Mansfield the prizes in 2003 for their discoveries concerning MRI.


Conceding that in many situations these imaging studies surpass the reliability of their neurologic examination, neurologists routinely order CT and MRI to evaluate patients’ dementia, aphasia, neuropsychologic deficits, seizures, and other conditions. Even in cases of apparent delirium, they order it to exclude an underlying structural lesion. Neurologists also use imaging studies to follow the course of certain illnesses, such as brain tumors and MS, because their clinical manifestations often fail to reflect disease activity as reliably as imaging studies.


On the other hand, neurologists do not routinely order imaging studies in evaluating patients with sleep disturbances, absence seizures, cluster and migraine headaches, Parkinson disease, tics, or essential tremor. They also find that imaging studies, while revealing the effects of certain illnesses on the brain and providing academically interesting information, do not help with patients’ diagnosis or management. For example, in autism, dyslexia and other learning disabilities, attention deficit hyperactivity disorder, Tourette disorder, Rett syndromes, and most psychiatric disorders, imaging studies usually show normal brains, small brains, or regional variations, such as cerebellar atrophy. These findings have neither the sensitivity nor specificity to offer diagnostic help.


When neurologists consult on psychiatric patients, they often recommend imaging studies, among other tests, for patients who have a first episode of psychosis, atypical psychosis, major depression after age 50 years, episodic behavioral disturbances, and, in some cases, anorexia. They also suggest imaging studies for patients prior to electroconvulsive treatment for several reasons. A CT or MRI might detect lesions that could explain the psychiatric symptoms without producing overt physical deficits, such as neurocysticercosis or extensive cerebral demyelination. Likewise, cerebral lesions may provoke status epilepticus or transtentorial herniation. Although helpful in many circumstances, imaging studies often fail to clarify the relationships, if any, between psychiatric symptoms and many common abnormalities that the studies uncover, such as cerebral atrophy, mild communicating hydrocephalus, small cerebral lesions, subcortical hyperintensities, and congenital abnormalities.



Computed Tomography


Using beams of ionizing radiation, which are essentially X-rays, CT generates images of the brain, other soft tissues, and skull. CT displays structures increasingly more radiodense than brain, such as tumors, blood, bone, calcifications, and surgical devices, in gradations increasingly closer to white than black. Similarly, it shows structures increasingly less radiodense than the brain, particularly the CSF-filled ventricles, in gradations increasingly closer to black. Thus, it shows in dark to black gradations several common lesions characterized by the absence of acute blood, such as cerebral infarctions, chronic subdural hematomas, edema surrounding tumors, and the center of cystic lesions. Likewise, it shows in light to white gradations several common lesions characterized by calcium or excessive blood, such as calcifications in the choroid plexus or meningiomas, acute subarachnoid, subdural, or intracerebral hemorrhages, and intraventricular shunts. By manipulating the software, CT and MRI can display the brain from three major perspectives: transaxial (axial, the conventional top-down view), coronal (front-to-back view), and sagittal (side view).


Although lacking fine detail, CT can clearly reveal changes in major structures (Fig. 20-1). It shows generalized cerebral atrophy, such as occurs in advanced age or Alzheimer disease (Figs 20-2 and 20-3), and atrophy of a particular region, such as with porencephaly (Fig. 20-4), Huntington disease (Fig. 20-5), and frontotemporal dementia (Fig. 20-6). Similarly, it shows expansion of the ventricles – hydrocephalus – not only as a consequence of generalized atrophy (hydrocephalus ex vacuo, Fig. 20-3), but also from normal-pressure hydrocephalus (Fig. 20-7) and CSF obstructions (obstructive hydrocephalus) (see later). CT readily detects large lesions, such as primary and metastatic tumors (Fig. 20-8). CT will also reveal subdural hematomas, except perhaps for isodense ones (Fig. 20-9). CT is even superior at finding dense, calcium-laden meningiomas (Fig. 20-10). It can show numerous small lesions, such as in toxoplasmosis (Fig. 20-11) and cysticercosis (Fig. 20-12), with the detail necessary for a firm diagnosis. (Cysticercosis, which is caused by the parasite Taenia solium, is the most common cerebral mass lesion in South and Central America.)



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FIGURE 20-2 This computed tomography (CT) scan illustrates generalized cerebral atrophy. (See Fig. 20-18 for magnetic resonance imaging appearance of cerebral atrophy.) Because of atrophy, the gyri shrink, sulci expand, cerebral cortex retracts from the inner table of the skull and from the falx (arrow), and ventricles expand (see later). Cerebral atrophy, as pictured in this case, represents a normal concomitant of old age. Although cerebral atrophy is associated with Alzheimer disease, vascular cognitive impairment, trisomy 21, alcoholism, neurodegenerative illnesses, and treatment-resistant schizophrenia, it is not invariably associated with dementia.




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FIGURE 20-5 A, This computed tomography (CT) scan shows the characteristic abnormality of Huntington disease: the anterior horns of the lateral ventricles are convex (bowed outward) because of atrophy of the caudate nuclei (arrows). Contrast that convex shape of the ventricles in Huntington disease to the concave shape seen in normal individuals (see Figs 20-1B and 20-17) and in those with cerebral atrophy and hydrocephalus ex vacuo (see Figs 20-2, 20-3, and 20-18). In addition to the caudate atrophy, Huntington disease, like many other neurodegenerative illnesses, causes cortical atrophy with widened sulci and enlarged ventricles. B, This coronal view of the MRI of the same patient also shows the convex expansion of the lateral ventricles, large sulci, and widened sylvian fissures (S).




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FIGURE 20-8 A, Computed tomography (CT) scan shows a glioblastoma with its characteristic white, contrast-enhanced ring (right) and black border of edema (arrows). (See Fig. 20-20 for magnetic resonance imaging showing a glioblastoma.) B, With contrast enhancement, CT shows several metastatic cerebral tumors (arrows).





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FIGURE 20-12 This computed tomography (CT) scan shows multiple cerebral cysticercosis lesions in views through the cerebrum (A) and cerebral cortex (B) and an enlargement of the frontal cortex lesion (C). These lesions, in contrast to toxoplasmosis (see Fig. 20-11), are usually situated in the cerebral cortex, contain calcification, and lack surrounding edema. Even though each cyst is small, together they exert a substantial cumulative mass effect and irritate the surrounding cerebral cortex. Their tendency to irritate the cerebral cortex explains why patients with cysticercosis often first come to medical attention because of seizures.


CT can also show strokes that are large established infarctions and those that are hemorrhagic (Fig. 20-13); however, MRI can better locate ones that are small or acute. CT is invaluable in the special situation of cerebellar hemorrhage, where rapid diagnosis is essential to prevent brainstem compression and obstructive hydrocephalus (Fig. 20-14).




Physicians routinely obtain head CT in suspected child abuse because 80% of cases include nonaccidental head injury (NAHI). Moreover, up to 50% of cases of NAHI result in neurologic deficits and 30% in fatality. Subdural hematomas – bilateral and of different ages – are the hallmark of NAHI.


The administration of an intravenous contrast solution during CT increases the density of blood-filled structures and whitens their image. This technique, contrast enhancement, highlights vascular structures, such as arteriovenous malformations (AVMs), glioblastomas, and membranes surrounding chronic subdural hematomas and cystic lesions (Fig. 20-15).



Although MRI holds many advantages, CT remains clinically indispensable, less expensive than MRI, and highly reliable. It is particularly valuable during emergencies, when speed is critical and gross anatomical pictures suffice. For example, the procedure, which may take as little as 8 minutes, satisfactorily reveals lesions that require immediate attention, such as epidural and acute subdural hematomas, large cerebellar hemorrhages, obstructive hydrocephalus, and subarachnoid hemorrhage. Also, patients with pacemakers, defibrillators, and other indwelling metallic devices, and those with claustrophobia can undergo CT but not MRI.


On the other hand, undergoing a CT exposes any patient to ionizing radiation. This radiation exposure potentially endangers children and adolescents because their dosage is relatively greater than for adults and their skull is thinner. Giving roughly the radiation of a skull X-ray series, a single head CT adds a measurable risk (0.07%) to the child’s lifetime cancer risk. Furthermore, dental X-rays and, more so, dental CTs add to their lifetime radiation exposure. Another consideration in children is that, because ocular lenses are highly susceptible to radiation, CT adds to the risk of developing radiation-induced cataracts.


Jun 4, 2016 | Posted by in NEUROLOGY | Comments Off on Lumbar Puncture and Imaging Studies

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