Major Cortical Association Bundles

Lesions to cortical association bundles can provide clinical relevance to fiber pathway tracts and cortical origins and destinations. For instance, a patient who develops acute damage to the uncinate fasciculus and right anterior frontal cortex (e.g., from a stroke) will have a “disconnection” between the temporal and frontal lobes. This individual may develop amnesia for experiences predating the stroke, along with impairment of self-awareness of personal experiences across time (this clinical finding is also known as a disruption of autonoetic consciousness).

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