Metabolic Syndrome
Three or more of the following risk factors are required for the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III criteria.
Risk Factor | Defining Level | |
|---|---|---|
Abdominal obesity | Waist circumference (at umbilicus) | |
Men | >102 cm (>40 in.) | |
Women | >88 cm (>35 in.) | |
Triglycerides | ≥150 mg/dL | |
HDL cholesterol | ||
Men | <40 mg/dL | |
Women | <50 mg/dL | |
Blood pressure | ≥130/≥85 mm Hg | |
Fasting glucose | ≥110 mg/dL | |
Reprinted from Janicak PG. Major mental disorders and the metabolic syndrome. A Supplement to Current Psychiatry. December 2004:4, with permission. | ||
Mental Illness and the Metabolic Syndrome
Risk factors contributing to the development of metabolic syndrome include poor nutrition, sedentary lifestyle, comorbid substance use, social isolation, financial hardship, noncompliance, limited access to medical care, decreased ability to care for self.
Treatment with psychiatric medications can cause and/or worsen these risk factors for metabolic syndrome.
Weight gain—clozapine, olanzapine > risperidone, quetiapine > aripiprazole, ziprasidone.
Risk for diabetes mellitus and lipid abnormalities—clozapine and olanzapine increased risk, aripiprazole and ziprasidone no known risk, olanzapine and risperidone unclear risk.Related posts:
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