Neurophysiology
QUESTIONS
1. A patient is found to be in a coma, and an electroencephalogram (EEG) is performed. Which of the following on the EEG would support the finding that this patient was in hepatic encephalopathy?
A. POST
B. Alpha rhythm
C. Triphasic waves (TWs)
D. 3-Hz spike and wave
E. None of the above
View Answer
1. Answer: C. TWs are a distinctive but nonspecific EEG pattern originally described in a stuporous patient. The pattern is most often associated with renal failure, hepatic encephalopathy, and anoxic brain injury.
2. Which of the following would be consistent with a brain tumor located in the left parietal lobe?
A. Spike and wave discharges on the right hemisphere
B. Delta wave in the left hemisphere
C. POST
D. Posterior dominant rhythm of 9 Hz
E. None of the above
View Answer
2. Answer: B. Focal delta activity is the classic electrographic sign of a local disturbance in cerebral function. If continuous delta, typically, a structural lesion is present. If no structural lesion is seen on CT scan or MRI of the head, it may be seen in the setting of trauma or postictal state after a seizure.
3. A 32-year-old female is diagnosed with optic neuritis. A visual evoked potential is tested. Which of the following is true?
A. Retrochiasmatic lesions would be best detected with this test.
B. Prolonged P-100 would be consistent with the diagnosis.
C. Temporal axons of the optic nerve cross anterior to the optic chiasm.
D. Carbamazepine usually shortens the latency of this test.
E. None of the above
View Answer
3. Answer: B. Prolonged P-100 is diagnostic of an abnormality in the optic nerve anterior to the chiasm. The retrochiasmatic portion of the optic nerve is not well tested with visual evoked potentials. The temporal portion of the optic nerve never crosses.
4. A 67-year-old male with early-onset dementia on no medication has an EEG. Which of the following would most likely be seen?
A. Alpha frequency of 8 Hz
B. Occasional temporal sharp waves
C. No reactivity
D. TWs
E. None of the above
View Answer
4. Answer: A. The early signs of dementia on EEG are reflected with slowing of the alpha frequency. The lower end of normal for alpha frequency is approximately 8.5 Hz. Medications can slow this down and therefore need to be excluded. The other answers are seen in disorders rather than just dementia.
5. A 56-year-old male with an episode of confusion is found to have transient global amnesia. Which of the following would be consistent with this diagnosis on EEG?
A. Normal
B. Slow background rhythm
C. 4-Hz spike and wave with photic stimulation
D. Occasional occipital sharps
E. None of the above
View Answer
5. Answer: A. Patients with transient global amnesia typically have normal EEG readings. Multiple different types of EEG readings, however, have been described such as bitemporal delta or bioccipital theta.
6. Which of the following diseases may be consistent with TWs?
A. Multi-infarct dementia
B. Creutzfeldt-Jakob disease
C. Parkinson’s disease
D. Progressive supranuclear palsy
E. None of the above
View Answer
6. Answer: B. The EEG shows a fairly typical repetitive pattern of BiPEDs (periodic epileptiform discharges) such as TWs, approximately 1 to 1.5 seconds apart. These are usually present during wakefulness and disappear during sleep. Periodic synchronous discharges are the hallmark of the disease.
7. Which of the following would be seen in a patient in stage I sleep (drowsy)?
A. Sleep spindles
B. Rapid eye movements
C. Slow roving eye movements
D. Periodic leg movements
E. None of the above
View Answer
7. Answer: C. Slow roving eye movements are typically seen during the drowsy state. Sleep spindles are part of stage II sleep. Rapid eye movements as stated are part of REM sleep. Periodic leg movements can be seen in any stage of sleep.
8. Which of the following are considered to be idiopathic generalized epilepsies?
A. West syndrome
B. Juvenile myoclonic epilepsy
C. Autosomal dominant frontal lobe epilepsy
D. Lennox-Gastaut syndrome
E. None of the above
View Answer
8. Answer: B. Idiopathic generalized epilepsies are genetic epilepsies that are not symptomatic or cryptogenic. Juvenile myoclonic epilepsy and absence are two of the more common generalized idiopathic epilepsies. The others listed are symptomatic (West syndrome, Lennox-Gastaut syndrome) or localized (autosomal dominant frontal lobe epilepsy).
9. Which of the following are not considered EEG artifacts?
A. Eye movements
B. Glossokinetic
C. Sweat
D. Respiration
E. None of the above
F. All of the above
10. A 45-year-old male with acute head trauma is encephalopathic. An EEG is performed and shows some amplitude asymmetry from one side to the other. Which of the following is a likely etiology?
A. Electrode malfunction
B. Underlying hematoma
C. History of seizures
D. Mesial temporal sclerosis
E. None of the above
View Answer
10. Answer: B. Any destructive lesion can clearly attenuate the amplitude of normal rhythms. The other options would not likely be causes of amplitude differences comparing hemispheres.
11. A 56-year-old male with a recent stroke is undergoing transcranial magnetic stimulation in a research study to see if he can regain function. Which of the following would not be a contraindication?
A. Pacemaker
B. Recent head trauma
C. History of epilepsy
D. Metallic foreign body
E. None of the above; they all are contraindications.
View Answer
11. Answer: E. All of the above are contraindications. History of epilepsy, however, is a relative contraindication.
12. A 32-year-old female with a recent history of optic neuritis undergoes visual evoked potentials. Which of the following statements is true regarding the visual evoked potentials?
A. Amplitude will be decreased
B. Prolongation of the P-100
C. Amplitude will be increased
D. Shortened P-100
E. None of the above
View Answer
12. Answer: B. Prolongation of the waveform on visual evoked potential would help support the diagnosis of optic neuritis. This is a demyelinating process, and therefore, there will be delay in transmission.
13. A 23-year-old male presents after severe head trauma due to a motor vehicle accident. He is found to be comatose, and an EEG is performed. Which of the following would favor a better prognosis?
A. Widespread continuous spindles
B. Minimal reactivity
C. Spindle coma with reactivity

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