Occlusive Cerebrovascular Disease
Vaso-occlusive Disease
1. True or False. A transient ischemic attack(TIA)is a focal neurological deficit lasting 24 hours but not more than 48 hours. | false(A TIA, by definition, lasts ≤ 24 hours.) | G6 p.869:50mm |
2. Complete the following about transient ischemic attack (TIA): |
| G7 p.1010:55mm |
a. TIA is usually_____. | short |
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b. Most last only_____ _____. | 10 minutes |
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c. 70% last only_____ _____. | 10 minutes |
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d. 90% last less than_____ _____. | 4 hours |
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e. If a deficit lasts more than 60 minutes, only_____% resolve in 24 hours. | 14% |
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3. Complete the following about RIND: |
| G6 p.869:60mm |
a. RIND stands for r_____i_____n_____d_____. | reversible ischemic neurologic deficit |
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b. |
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i. It is defined as a n_____d_____ | neurologic deficit |
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ii. that lasts >_____hours but less than_____ _____. | 24 hours; 1 week |
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iii. Frequency of occurrence is_____%. | 2.5% |
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4. With atherosclerotic cerebrovascular disease(CVA), atherosclerotic plaques |
| G7 p1144:70mm |
a. begin to form as early as age_____ | 20 |
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b. begin on the back wall of the_____ _____ _____ | common carotid artery |
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c. risk of CVA correlates with |
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i. s_____ | stenosis |
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ii. u_____ | ulcerations |
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iii. h_____ | hypercoagulable |
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iv. v_____ | viscosity |
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5. True or False. Patients with a depressed level of consciousness or an acute fixed deficit should undergo emergency carotid endarterectomy. | false(These are two contraindications to emergency CEA.) | G6 p.880:20mm |
Atherosclerotic Cerebrovascular Disease
6. Carotid artery lesions |
| G7 p.1144:95mm |
a. are considered symptomatic if | ||
i. there is _____ or _____ ischemic episodes | one or more |
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ii. in the _____ of the vessel. | distribution |
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b. True or False. They are considered asymptomatic if the patient only has |
| |
i. visual complaints | true |
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ii. Dizziness | true |
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iii. Syncope | true |
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7. In a patient with carotid plaque categorize the following: |
| G7 p.1144:95mm |
a. blurred vision | asymptomatic |
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b. aphasia for less than 24 hours | symptomatic |
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c. weakness of arm for 10 min | symptomatic |
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d. dizziness | asymptomatic |
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8. True or False. The stroke rate in a patient with asymptomatic carotid bruit is approximately |
| G7 p.1144:108mm |
a. 0% | false |
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b. 2% | true |
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c. 8% | false |
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d. 22% | false |
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9. True or False. The central retinal artery is often insufficient in cerebrovascular disease. This artery is a branch of the following: |
| G7 p.1144:126mm |
a. posterior cerebral artery | false |
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b. orbital artery | false |
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c. ophthalmic artery | true |
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d. M2 | false |
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e. anterior communicating artery | false |
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10. Retinal insufficiency can manifest by |
| G7 p.1144:126mm |
a. temporary loss of vision, aka _____ _____ | amaurosis fugax |
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b. True or False. Such loss of vision is | ||
i. bilateral | false |
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ii. Contralateral | false |
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iii. Ipsilateral | true |
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iv. Homonymous | false | |
c. There are four types. |
| G7 p.1144:136mm |
i. Type I is called “black curtain” due to _____. | emboli |
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ii. Type III is called “gray vision” due to _____. | hypoperfusion |
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iii. Type III is associated with migraines and the cause is _____. | Vasospastic |
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iv. Type IV is associated with anti cardio lipin antibodies, and the cause is _____. | miscellaneous |
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v. Blindness may be _____. | permanent |
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11. What are Hollenhorst plaques? | cholesterol crystal emboli seen on funduscopic examination in patients with carotid artery disease | G7 p.1145:178mm |
12. Complete the following about the classification of carotid ulcerations: |
| G7 p.1145:18mm |
a. Type A is s_____ s_____s_____. | small smooth shallow |
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b. Type B is l_____ d_____. | large deep |
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c. Type C is c_____ c_____. | complex cavitated |
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d. Annual stroke rate for type A is _____%. | 0.5% |
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e. Annual stroke rate for type B is _____%. | 0.4 to 4.5% |
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f. Annual stroke rate for type C is _____%. | 5 to 7% |
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13. What is the gold standard for evaluation of carotid artery disease? | angiography | G7 p.1145:63mm |
14. In the arteriosclerotic patient what is the risk that angiography will cause a cerebrovascular accident (CVA)? | Less than 1% risk of CVA | G7 p.1145:71mm |
15. Complete the following about Nascet study: |
| G7 p.1145:90mm |
a. Nascet stands for _____. | North American Symptomatic Carotid Endarterectomy Trial |
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b. It measures degree of c_____s_____. | carotid stenosis |
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c. Formula is _____ =% stenosis |
| |
d. where N is measured at maximal _____ | narrowing | |
e. | ||
i. where D is measured _____ | distal | |
ii. to the _____ _____ | carotid bulb |
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iii. where the walls become _____ | parallel |
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f. Surgery is not indicated for less than _____%. | 40% | |
16. Complete the following about duplex Doppler ultrasound limitations: |
| G7 p.1145:165mm |
a. It can’t scan above the angle of the _____. | Mandible |
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b. It performs poorly with the _____ _____. | string sign |
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c. Depth of penetration is greater with _____ _____. | lower frequencies |
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d. Signal definition is better with _____ _____. | higher frequencies |
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17. True or False. Ultrasound of the carotid artery is excellent for evaluating patients with “the string sign.” | false (Ultrasound is very poor for evaluation of such low flow states.) | G7 p.1145:168mm |
18. The use of magnetic resonance angiography |
| G7 p.1145:180mm |
a. may demonstrate a flow _____ | gap |
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b. which obviates the need for _____. | angiography |
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c. It may _____ the degree of carotid stenosis. | underestimate |
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19. True or False. The following irreversibly inhibits cyclooxygenase: |
| G7 p.1146:166mm |
a. ticlodipine | false |
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b. aspirin | true (Aspirin irreversibly inhibits cyclooxygenase preventing synthesis of vascular prostacyclin and platelet thromboxane A2. Platelets cannot resynthesize cyclooxygenase, whereas the vascular tissues do so rapidly.) |
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c. clopidogrel | false |
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d. prednisone | false |
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20. Aspirin |
| G7 p.1147:16mm |
a. The optimal dose for cerebrovascular ischemia is _____. | debated |
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b. | ||
i. Risk of stroke after TIA can be reduced by _____to _____% | 25 to 30% |
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ii. by the use of _____ mg PO per day. | 325 |
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c. True or False. More mg of ASA is better after TIA. | false |
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d. Daily doses of 81 or 325 mgm were _____ than higher doses. | better |
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e. CVA, MI and death were reduced to _____% from _____%. | 6.2 from 8.2 |
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21. Complete the following about Plavix: |
| G7 p.1147:55mm |
a. Has a lower incidence of _____ | neutropenia |
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b. Needs to be taken _____ per day | once |
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c. Requires _____ days off the drug to reverse | 5 | |
22. Complete the following about asymptomatic carotid artery stenosis: |
| G7 p.1147:120mm |
a. stroke rate of _____% per year | 2% |
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b. percent that are not disabling is _____% | 50% |
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c. Carotid endarterectomy may be beneficial for stenosis of more than _____%. | 60% |
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23. True or False. The annual stroke rate for patients with symptomatic carotid stenosis is |
| G7 p.1148:95mm |
a. 30% | false |
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b. 5% | false |
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c. 1 to 3.4% | true |
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d. 1% | false |
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24. True or False. The Asymptomatic Carotid Atherosclerosis Study (ACAS) found that surgery is moderately beneficial for asymptomatic carotid stenosis ≥ 60%. | true | G7 p.1149:20mm |
Carotid Endarterectomy
25. True or False. The North American Symptomatic Carotid Endarterectomy Trial (NASCET) found that in patients with a recent TIA and ipsilateral stenosis > 70%, carotid endarterectomy (CEA) reduced the risk of CVA by | G7 p.1150:85mm | |
a. 17% | true (at 18 months follow-up) |
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b. 80% | false |
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c. 60% | false |
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d. It did not reduce the risk. | false |
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26. The general trend in carotid endarterectomy surgery is to wait only _____ days after CVA to perform an endarterectomy. | 7 | G7 p.1151:26mm |
27. True or False. Aspirin and dipyridamole have been shown unequivocally to reduce the rate of restenosis after CEA. | false (The use of these medications has not been shown to reduce the rate of restenosis after CEA.) | G7 p.1152:145mm |
28. Complete the following about postop check after carotid endarterectomy: | G7 p.1152:165mm | |
a. Pronator drift to rule out _____ _____ new hemiparesis | ||
b. Dysphasia to rule out _____ _____ _____ | dominant hemisphere CVA |
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c. Pupil size to rule out _____ _____ | Horner syndrome | |
d. STA pulsations to rule out _____ _____ _____ | external carotid occlusion |
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e. Tongue deviation to identify _____ _____ _____ | XII nerve injury |
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f. | ||
i. Hoarseness consider _____ _____ | laryngeal edema |
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ii. Or _____ _____ nerve injury | recurrent laryngeal |
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g. Tracheal deviation to identify postop _____ | hematoma |
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29. List postop complications of carotid endarterectomy. | G7 p.1153:35mm | |
Hint: c-h4arm2s2 | ||
a. c_____ | cranial nerve injury |
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b. h_____ | headache |
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c. h_____ | hoarseness |
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d. h_____ | hyperperfusion |
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e. h_____ | hypertension |
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f. a_____ | arteriotomy disruption |
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g. r_____ | restenosis |
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h. m_____ | morbidity |
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i. m_____ | mortality |
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j. s_____ | seizures |
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k. s_____ | stroke |
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30. Complete the following about carotid endarterectomy: | G7 p.1153:40mm | |
a. Morbidity: absolute upper limit is _____%. | 3% |
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b. Mortality in hospital is _____%. | 1% |
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31. Complete the following about arteriotomy disruption: | G7 p.1153:41mm | |
a. Most immediate danger is _____ | asphyxiation |
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b. Symptoms and signs | ||
i. Swelling of _____ | neck |
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ii. Swallowing _____ | difficulty |
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iii. Deviation of _____ | trachea |
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iv. Air _____ | hunger |
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v. Late _____ _____ | false aneurysm |
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32. Complete the following about stroke: |
| G7 p.1153:83mm |
a. Infarcation incidence: _____% | 5% |
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b. Hemorrhagic incidence: _____% | 0.6% |
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33. What is the most common cause of | G7 p.1153:102mm | |
a. minor post-CEA CVA? | emboli |
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b. major post-CEA CVA? | postoperative ICA occlusion |
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34. Risk of stroke is related to | G7 p.1153:107mm | |
a. t_____ | technique |
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b. h_____ | state hypercoaguable |
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c. h_____ reaction | heparin |
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d. Endarterectomy site is t_____ | thrombogenic | |
35. Complete the following about seizures: |
| G7 p.1153:139mm |
a. Most occur postop day _____ to _____ | 5 to 13 |
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b. Usually _____ | focal |
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c. Incidence _____% | 1% |
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36. Complete the following about restenosis after CEA surgery: |
| G7 p.1153:150mm |
a. within 2 years is usually due to _____ _____ | fibrous hyperplasia |
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b. after 2 years is usually due to _____ | atherosclerosis |
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37. Complete the following about late restenosis: |
| G7 p.1153:152mm |
a. It occurs within the first year in _____%. | 25% |
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b. If it occurs within 2 years, it is due to f_____ h_____. | fibrous hyperplasia |
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c. If it occurs after 2 years, it is due to a _____. | atherosclerosis |
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38. Complete the following about cerebral hyperperfusion syndrome: |
| G7 p.1153:158mm |
a. Due to return of blood to area of lost _____ | autoregulation |
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b. Usually from chronic cerebral _____ | ischemia |
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c. Secondary to high-grade _____ | stenosis |
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d. May result in _____ _____ | intracerebral hemorrhage |
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39. True or false. Hoarseness is most likely caused by |
| G7 p.1153:175mm |
a. superior laryngeal nerve injury | false |
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b. laryngeal edema | true |
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c. recurrent laryngeal nerve injury | false |
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40. Complete the following about hypoglossal nerve injury: |
| G7 p.1154:16mm |
a. Incidence is _____%. | 1% |
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b. Tongue deviates _____ _____ _____ of the injury. | toward the side |
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c. Unilateral injury causes problem with | ||
i. sp_____ | speaking |
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ii. sw_____ | swallowing |
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iii. c_____ | chewing |
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d. Bilateral injury can cause a_____ o_____. | airway obstruction |
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e. It may last as long as _____ months. | 4 months |
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f. Palsy is a contraindication to doing endarterectomy. | Contralaterally | |
41. Complete the following about endarterectomy and vocal cord paralysis: |
| G7 p.1154:30mm |
a. Incidence is _____%. | 1% |
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b. Which side would be affected? | Ipsilateral |
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c. Due to injury to |
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i. v_____ nerve | vagus |
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ii. r_____ l_____ nerve | recurrent laryngeal |
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42. Damage to which nerve could cause postoperative lip asymmetry following CEA? (i.e., not due to stroke) | marginal mandibular branch of facial nerve MMB-VII (usually a retraction injury with the nerve being retracted against the mandible) | G7 p.1154:37mm |
43. Complete the following about hypertension: |
| G7 p.1154:42mm |
a. May develop _____ to _____ days after CEA | 5 to 7 |
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b. Due to loss of the carotid s_____ b_____ reflex | sinus baroreceptor |
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44. True or False. Immediately following CEA (i.e., in the post-anesthesia care unit), a patient who developed neurologic deficit in the distribution of the endarterectomized carotid should undergo immediate computed tomography/magnetic resonance imaging (CT/MRI) or angiogram. | false (The patient should be emergently reexplored. There is no deficit if flow is reestablished in 45 minutes.) | G7 p.1154:40mm |
45. True or False. When performing CEA, the order of removing clamps after completion of endarterectomy is |
| G7 p.1154:80mm |
a. internal, common, external carotid | false |
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b. internal, external, common carotid | false |
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c. external, common, internal carotid | true (This ensures that any embolic material will be flushed to the external carotid circulation.) |
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d. The order of removal does not matter. | false |
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46. True or False. When performing reexploration of a CEA occlude in the following order: |
| G7 p.1154:84mm |
a. Internal, common, external | false |
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b. Internal, external, common | false |
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c. External, common, internal | false |
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d. Common, external, internal | true |
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47. Complete the following about arteriotomy disruption: |
| G7 p.1154:125mm |
a. If you notice difficulty breathing _____ _____ | open wound | |
b. then i_____. | Intubate |
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c. This may be difficult if the _____ is deviated. | trachea |
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48. True or False. A patient with disruption of arteriotomy closure following carotid surgery should never be intubated. | false (Intubation is a high priority.) | G7 p.1154:137mm |
49. Complete the following about anesthesia and monitoring: |
| G7 p.1154:165mm |
a. Hemodynamic intolerance to clamping occurs in _____%. | 1 to 4% |
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b. If identified, place a vascular _____. | shunt |
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c. Which is safer: local or general anesthesia? | no difference |
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d. Add thiopental to general anesthesia until EEG burst suppression lasts for _____ to _____ seconds. | 15 to 30 |
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50. True or False. A shunt is commonly used in carotid surgery when the stump pressure is less than |
| G7 p.1155:48mm |
a. 100 mm Hg | false |
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b. 25 mm Hg | true |
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c. 1 mm Hg | false |
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d. Never use a shunt | false |
|
51. Surgical results correlate best with _____ neurologic status. | presenting | G7 p.1157:75mm |
52. Totally occluded carotid and patient presents with mild neurologic deficit. |
| G7 p.1157:165mm |
a. Assume _____ occlusion | chronic |
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b. Have stroke rate of _____ to _____% per year | 3 to 5% |
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53. Complete the following about acute carotid occlusion: |
| G7 p.1157:165mm |
a. Some neurologic deficit in _____ to _____ | %40 to 70% |
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b. Mortality: _____ to _____% | 15 to 55% |
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c. Good recovery in _____ to _____% | 2 to 12% |
|
54. Six of the symptoms of vertebrobasilar insufficiency (VBI) begin with the letter “d.” They are |
| G7 p.1158:110mm |
a. dr_____ _____ | drop attack |
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b. di_____ | diplopia |
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c. dy_____ | dysarthria |
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d. de_____ _____ _____ | defect in vision |
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e. diz_____ | dizziness |
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f. de_____ b_____ | deficit bilaterally (motor and/or sensory) | |
55. Answer the following about vertebrobasilar insufficiency (VBI): |
| G7 p.1158:125mm |
a. Clinical diagnosis of VBI requires how many of those criteria? | 2 or more |
|
b. Which symptom suggests: |
|
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i. Ischemia to the brain? | diplopia near ocular nuclear |
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ii. Ischemia to lower brain stem? | Dysarthria |
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iii. Ischemia to occipital cortex? | homonymous hemianopsia |
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56. Complete the following about vision symptoms: |
| G7 p.1158:140mm |
a. |
|
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i. Carotid artery vision symptoms are _____ | unilateral |
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ii. For example, a_____ f_____ | amaurosis fugax |
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b. |
|
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i. Vertebral artery symptoms are _____ | bilateral |
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ii. For example, h_____ h_____ | homonymous hemianopsia |
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57. If a patient has transient episodes of vertigo you may suspect _____. | VBI | G7 p.1158:146mm |
58. The most common cause of VBI |
| G7 p.1158:185mm |
a. is s_____ s_____ | subclavian steal |
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b. |
|
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i. which is r_____ f_____ in the VA | reversed flow |
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ii. due to p_____ s_____ | proximal stenosis |
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iii. of the s_____ a_____. | subclavian artery |
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59. The mainstay treatment of VBI is a_____. | anticoagulation | G7 p.1159:70mm |
60. Complete the following regarding bow hunter’s stroke: |
| G7 p.1159:105mm |
a. Bow hunter’s stroke is caused by occlusion of the _____ _____ | vertebral artery |
|
b. resulting from _____ _____. | head rotation |
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c. Can this occur from forceful treatment by a chiropractor? | yes |
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d. The vessel occluded is _____ to the direction of head rotation. | Contralateral |
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e. It is more likely in patients with incompetent _____ _____ arteries. | posterior communicating |
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f. An appropriate test for this condition is _____ _____ _____. | dynamic cerebral angiography (DCA) |
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g. If condition is proved treatment of choice is _____ _____ _____. | decompression of VA atC1-2 |
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h. If still symptomatic treatment is_____ _____. | C1-2 fusion |
|
Cerebral Arterial Dissections
61. True or False. The following are features of cerebral arterial dissections: |
| G7 p.1160:125mm |
a. Hemorrhage into medial layer | true |
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b. Presentation includes pain, subarachnoid hemorrhage (SAH), TIA, and Horner syndrome. | true |
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c. Extracranial dissection is treatedsurgically. | false |
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d. Intracranial dissections with SAH are treated surgically. | false |
|
62. True or False. Regarding arterial dissection: |
| G7 p.1161:22mm |
a. Hemorrhage can occur outside the vascular lumen due to transintimal extravasation of hematoma. | true |
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b. The hematoma may dissect the internal elastic membrane from the intima. | true |
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c. Subintimal dissection is more common with extracranial lesions. | false (Subintimal dissection is more common with intracranial dissection—subintimal = intracranial.) |
|
d. Dissection of the internal elastic membrane results in luminal narrowing. | true |
|
63. Matching. Match the dissection with its location. |
| G7 p.1161:38mm |
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a. intracranial dissection |
| |
b. extracranial dissection |
|
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64. Matching. Rank the following dissection sites in order of frequency of occurrence and give their approximate percentages: |
| G7 p.1161:103mm |
|
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a. ACA/PCA/PICA _____% |
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b. basilar/ICA/MCA _____% |
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c. vertebral _____% |
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65. True or False. Headache usually precedes neurologic deficits by less than 1 hour. | false (Headache usually precedes deficits by days to weeks.) | |
66. True or False. The most reliable finding on radiographic examination of suspected arterial dissections is |
| G7 p.1162:90mm |
a. direct visualization on CT | false |
|
b. crescent sign on T2-weighted (T2W) axial imaging | false |
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c. string sign on angiography | false |
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d. double lumen sign on angiography | true (Double lumen sign on angiography is considered pathognomonic.) |
|
67. True or False. In cerebral arterial dissection the angiographic configuration is expected |
| G7 p.1162:105mm |
a. to remain stable | false |
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b. to resolve or worsen | true |
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c. to often change | true |
|
68. Mortality in cerebral arterial dissections is higher in |
| G7 p.1162:150mm |
a. _____ lesions | carotid |
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b. carotid _____% | 49% |
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c. vertebrobasilar artery (VBA) _____% | 22% |
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d. subarachnoid hemorrhage _____% | 24 |
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e. non-SAH patients _____% | 29 |
|
69. Complete the following regarding carotid dissection: |
| G7 p.1163:15mm |
a. True or False. The most frequent presenting symptom of spontaneous ICA dissection is |
|
|
i. neck pain | false (Pain is 9% more common in VBA.) |
|
ii. neck swelling | false (swelling 2%) |
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iii. headache | true (headache 59%) |
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iv. oculosympathetic palsy (partial Horner syndrome) | false (30%) |
|
70. Complete the following about vertebral artery dissection: |
| G7 p.1163:85mm |
a. Categories: |
|
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i. s_____ | spontaneous |
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ii. a_____ | aneurysmal |
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iii. t_____ | traumatic |
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b. True or False. Frequency: |
|
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i. Carotid dissections are more common. | true |
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ii. Vertebral dissections are more common. | false | |
71. Complete the following regarding cerebral arterial dissections: |
| G6 p.885:150mm |
a. True or False. Posttraumatic ICA dissection injury mechanisms include |
|
|
i. chiropractic manipulation | true |
|
ii. attempted strangulation | true |
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iii. postangiography | true |
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iv. hyperextension of neck with ICA stretch | true (compress ⇒ stretch ⇒ dissection risk poke ⇒ tweak ⇒) |
|
b. After trauma symptoms manifest within_____ hours _____%. | 24 hours; 75% | G6 p.885:180mm |
c. The most frequent presenting symptom of posttraumatic ICA dissection is _____ _____. | ischemic symptoms |
|
d. Which is more common: traumatic or spontaneous ICA dissection? | traumatic |
|
72. True or False. Persistent embolic complications of ICA dissection are indications for the following interventions: |
| G6 p.886:50mm |
a. interposition venous grafting | true |
|
b. EC/IC bypass with maintenance of ICA luminal integrity | false (Extracranial/intracranial [EC/IC] bypass is okay, but once you bypass the clot, close the ICA off to reduce further embolic risk.) |
|
c. carotid ligation alone | true |
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d. heparin-warfarin-based anticoagulation with close angiographic observation | true |
|
73. Complete the following about traumatic dissections: |
| G7 p.1163:97mm |
a. Occur where VA crosses _____ _____ | bony prominences |
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b. Typically the _____ – _____ junction | C1-2 |
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c. Can result from |
|
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i. Manipulation of _____ | neck |
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ii. Automobile a_____ | accidents |
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iii. C_____ treatment | chiropractic |
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iv. Sudden head _____ | turning |
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v. Blow to _____ of _____ | back of neck |
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d. Can produce massive _____ hematomas | neck | G7 p.1164:15mm |
e. |
|
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i. Angiography demonstrates lesion posterior to the _____ | atlas |
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ii. Which is the distal extracranial _____ _____ | third segment |
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f. The first and third portions of the VA are _____. | movable |
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g. The second and fourth portions are immobilized by _____. | bone | |
h. Most commonly angiography |
|
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i. demonstrates _____ _____ | irregular stenosis |
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ii. of the horizontal loops as they pass _____. | C1 |
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74. Complete the following about spontaneous dissection: |
| G7 p.1163:112mm |
a. Tends to be _____ | intracranial |
|
b. Occur on the _____VA | dominant |
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c. Associated with |
|
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i. f_____ d_____ | fibromuscular dysplasia |
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ii. m_____ | migraine |
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iii. o_____ c_____ | oral contraceptives |
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d. More common in _____ _____ | young adults |
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e. Have other sites of dissection _____% | 36% |
|
f. Have bilateral VA dissection _____% | 21% |
|
75. True or False. Dissecting aneurysms of the vertebrobasilar arteries commonly present as |
| G7 p.1163:125mm |
a. saccular aneurysms | false |
|
b. fusifom aneurysms | true |
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c. subarachnoid hemorrhage | true |
|
d. are ameniable to clipping | may be |
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e. altered consciousness | true |
|
76. Although most spontaneous vertebral artery dissections are intracranial, those that are extracranial present with _____ _____. | occipital pain | G7 p.1163:155mm |
77. True or False. Dissecting aneurysms of the vertebrobasilar arteries commonly present as |
| G7 p.1163:175mm |
a. saccular aneurysms | false |
|
b. fusiform dilatation | true |
|
c. subarachnoid hemorrhage | true |
|
78. Matching. Match the treatment with the condition. |
| G7 p. 1164:70mm |
Treatment: |
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|
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|
|
Condition: |
|
|
a. subarachnoid hemorrhage |
| |
b. intradural dissection |
| |
c. extradural dissections that progress clinically or angiographically despite anticoagulation |
| |
d. non-hemorrhagic small infarction | G6 p. 886:116mm |
Cerebrovascular Venous Thrombosis
79. True or False. The following are conditions associated with dural sinus thrombosis formation: |
| G7 p.1166:80mm |
a. oral contraceptives | true |
|
b. ulcerative colitis | true |
|
c. dehydration | true |
|
d. peripheral vascular disease | false |
|
e. infection | true |
|
f. hypercoagulable state | true |
|
g. pregnancy | true |
|
h. trauma | true |
|
80. Hypercoagulable state includes |
| G7 p.1166:135mm |
(Hint: a2p4rs) |
|
|
a. a_____ III deficiency | antithrombin |
|
b. a_____ antibodies | antiphospholipid |
|
c. p_____ C deficiency | protein |
|
d. p_____ S deficiency | protein |
|
e. p_____ _____ hemoglobinuria | paroxysmal nocturnal |
|
f. p_____ deficiency | plasminogen |
|
g. r_____ to activated protein C | resistance |
|
h. s_____ lupus erythematosis | systemic |
|
81. Complete the following about cerebrovascular venous thrombosis: |
| G7 p.1167:15mm |
a. Incidence is 1 in _____ births. | 10,000 |
|
b. Period of highest risk of cerebrovascular venous thrombosis during the puerperium is within the first _____ _____ after delivery. | 2 weeks |
|
82. True or False. Dural sinus thrombosis occurs more often in the superior sagittal sinus and the |
| G7 p.1167:40mm |
a. right transverse sinus | false |
|
b. left transverse sinus | true |
|
c. straight sinus | false |
|
d. inferior sagittal sinus | false |
|
83. Incidence of dural sinus thrombosis (DST) |
| G7 p.1164:47mm |
a. in the superior sagittal sinus is_____% | 70% |
|
b. in the left transverse sinus is _____% | 70% |
|
c. in multiple sinuses is _____% | 71% |
|
84. Complete the following about clinical symptoms from superior sagittal sinus thrombosis (SSS): |
| G7 p.1167:125mm |
a. No symptoms _____ _____ | anterior third |
|
b. Spastically, increased muscle tone _____ _____ | middle third |
|
c. Cortical blindness or edema, or death_____ _____ | posterior third | |
85. What are the clinical symptoms of thrombosis of SSS? |
| G7 p.1167:126mm |
a. Anterior third: may produce _____ _____ | no symptoms |
|
b. Middle third: may produce _____ | spasticity |
|
c. Thrombosis of posterior third: may produce _____, _____, _____ | blindness, edema, death |
|
86. Thrombosis of the jugular bulb may produce the following syndrome: |
| G7 p.1167:152mm |
a. symptoms (Hint: bash) |
|
|
i. b_____ | breathlessness |
|
ii. a_____ | aphonia |
|
iii. s_____ | swallowing difficulties |
|
iv. h_____ | hoarseness |
|
b. named _____ _____ | Vernet syndrome | also see G6 p.86:140mm |
c. nerves involved are _____ _____ _____ | 9, 10, 11 |
|
d. due to compression of the pars _____ | nervosa |
|
87. The best way to diagnose thrombosis of a venous sinus is by |
| G7 p.1167:175mm |
a. M_____ or | MRI |
|
b. a_____. | angiography |
|
88. With dural sinus thrombosis and plain CT scan, suspect the diagnosis of DST. |
| G7 p.1168:20mm |
a. May be _____ in 20% | normal |
|
b. Intraparenchymal f_____ hemorrhage _____% | flame; 20% |
|
c. Small v_____ in _____% | ventricles; 50% |
|
d. White matter e_____ | edema |
|
e. Above changes occurring b_____ | bilaterally |
|
89. Thrombosis of the superior sagittal sinus |
| G7 p.1168:44mm |
a. may produce a configuration on CT scan called a _____ _____, | delta sign |
|
b. which represents _____ _____ in the _____ | clotted blood in the sinus |
|
c. or on a CT with contrast it may produce an _____ _____ _____. | empty delta sign | |
90. Complete the following about delta sign types: |
| G7 p1168:46mm |
a. Delta sign—a triangular-shaped configuration—is seen on |
|
|
i. CT _____ contrast | without |
|
ii. Represents _____ _____ | clotted blood |
|
iii. _____ the sinus | within |
|
b. Pseudo delta sign is |
|
|
i. CT _____ contrast | without |
|
ii. Represents _____ around SSS | SAH |
|
c. Empty delta sign is seen in |
|
|
i. CT _____ contrast | with |
|
ii. Represents enhancement of _____ | dura |
|
iii. More so than the intra sinus _____ | clot |
|
91. True or False. The following are benefits of assessing thrombosis of the superior sagittal sinus with MRI: |
| G7 p.1168:95mm |
a. preferred diagnostic procedure | true |
|
b. can demonstrate vascular changes | true |
|
c. can demonstrate parenchymal changes | true |
|
d. can identify congenital absence of sinus | true |
|
e. shows cerebral edema | true |
|
f. can estimate age of thrombosis | true |
|
g. more advantageous than angiography | true |
|
92. Complete the following regarding cerebrovascular venous thrombosis: |
| G7 p.1169:65mm |
a. True or False. Heparin is the treatment of choice for dural venous sinus thrombosis with associated intracranial hemorrhage. | true |
|
b. Must not treat |
|
|
i. with _____ | steroids |
|
ii. because they reduce _____ and sthereby increase _____ | fibrinolysis; thrombosis |
|
c. Should also correct |
|
|
i. _____ _____ | underlying abnormality (i.e., use antibiotics) |
|
ii. and control _____ | hypertension |
|
d. continue anticoagulation for _____ to _____ months | 3 to 6 | G7 p.1169:175mm |
93. What is the prognosis of superior sagittal sinus (SSS) thrombosis? |
| G7 p.1170:65mm |
a. Mortality is _____%. | 5 to 70% (approximately 30%) |
|
b. Poor prognostic indicators are |
|
|
i. e _____ of a_____ | extremes of age (infancy or old age) |
|
ii. c_____ | coma |
|
iii. n_____ d_____ | neurological deterioration (rapid) |
|
c. Treatment for visual loss from papilledema is o_____ n_____ s_____ f_____. | optic nerve sheath fenestration | G7 p.1169:170mm |
Moyamoya Disease
94. Complete the following regarding moyamoya disease: |
| G7 p.1170:125mm |
a. Moyamoya means p_____ o_____ s_____. | puff of smoke |
|
b. Skull base arteries are _____ | narrowed |
|
c. due to a thickened _____. | intima |
|
d. _____ deposits occur | Lipid |
|
e. without evidence of _____. | inflammation |
|
f. The other vascular abnormality that occurs is _____, which | aneurysms (intracranial) | G7 p.1171:65mm |
g. may be due to a _____ defect in the wall. | congenital |
|
h. Aneurysms occur in unusual sites. |
|
|
i. Cerebral arteries at their _____ | periphery |
|
ii. Posterior/anterior _____ | choroidal |
|
iii. Recurrent artery of _____ | Heubner |
|
iv. Frequency of VB aneurysms is _____% | 62% |
|
i. The country with highest incidence is_____. | Japan |
|
j. If untreated the prognosis of major deficit or death in 2 years is _____%. | 73% |
|
k. Treated prognosis is good in _____%. | 58% |
|
95. Presentation in |
| G7 p.1171:150mm |
a. children is by _____ attacks | ischemic |
|
b. adults is by _____ | hemorrhage |
|
c. Diagnose with |
|
|
i. a_____ | angiography |
|
ii. M_____ | MRA |
|
d. The best medical treatment is _____. | none known to be beneficial |
|
e. Surgical treatments all involve _____. | revascularization | G7 p.1173:100mm |
f. The surgical procedure of choice is _____ _____ _____. | superficial temporal artery—middle cerebral artery (STAMCA) bypass |
|
96. What is the treatment for moyamoya disease? |
| G7 p.1173:120mm |
a. EMS = _____ | encephalomyosynangiosis |
|
b. EDAS = _____ | encephaloduroarterio-synangiosis |
|
c. OPT = _____ | omental pedicle transplantation |
|

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