of Patients Without Neuropsychological Deficits Following Aneurysmal Subarachnoid Haemorrhage

 

Patients without NPD

Patients with NPD

p value

Age

Mean value (years ± SD)

51.9 ± 11.8

51.4 ± 11.6

p = 0.718a

Women/men ratio

1:1

1.7:1

p = 0.705b

Admission scores
   
GCS (median)

15.00

14.00

p = 0.012a

WFNS (median)

1.00

2.00

p = 0.011a

Fisher (median)

2.00

3.00

p = 0.001a

Aneurysm bearing artery

Acom + ACA

3 (37.5 %)

38 (45.2 %)
 
MCA

2 (25.0 %)

22 (26.2 %)
 
ICA + Pcom

3 (37.5 %)

14 (16.7 %)
 
Vertebrobasilar


10 (11.9 %)
 
Aneurysm location
  
p = 0.591b

Anterior circulation

8 (100 %)

74 (88.1 %)
 
Posterior circulation


10 (11.9 %)
 
Aneurysm size

Mean value (mm ± SD)

6.3 ± 2.0

6.5 ± 2.6

p = 0.817a


ACA anterior cerebral artery, Acom anterior communicating artery, GCS Glasgow Coma Scale, ICA internal cerebral artery, MCA medial cerebral artery, NPD neuropsychological deficit, Pcom posterior communicating artery, SD standard deviation, WFNS World Federation of Neurological Surgeons grading scale

aTwo-tailed Mann–Whitney tests were used for analysis

bTwo-tailed Fisher tests were used for analysis



Table 2 shows information on the clinical course and the treatment performed in patients of both study groups. Acute hydrocephalus requiring CSF diversion was associated with neuropsychological morbidity after discharge (p = 0.009). Aneurysm occlusion was performed within 72 h after haemorrhage, whenever feasible. A total of 58 aneurysms were clipped and 36 aneurysms were occluded using endovascular techniques (including 34 coiling procedures; one stent-assisted coiling and one aneurysm was primarily stented). Patients without NPD were distributed equally between the two modalities of aneurysm therapy (p = 0.706). No patient with regular neuropsychological outcome required shunt surgery for chronic hydrocephalus (p = 0.019). Two of 12 patients who required decompressive hemicraniectomy (DHC) for elevated intracranial pressure (ICP) refractory to maximal conservative therapy showed no NPD at the follow-up (p = 0.590). Patients without NPD showed a tendency towards a lower rate of CVS (12.5 vs. 45.2 %; p = 0.131) and none developed DCI (0 vs. 33.3 %; p = 0.100). Patients with regular neuropsychological outcome were discharged significantly earlier than patients with cognitive constraint (p < 0.001).


Table 2
Information on the clinical course and the treatment performed in patients of both study groups




























































 
Patients without NPD

Patients with NPD

p value

ICP – therapy/CSF – diversion

EVD/lumbar drain placement

1 (12.5 %)

52 (61.9 %)

p = 0.009a

Shunt placement


38 (45.2 %)

p = 0.019a

DHC

2 (25.0 %)

10 (11.9 %)

p = 0.590a

Aneurysm treatment
   
p = 0.706a

Microsurgical clipping

4 (50.0 %)

54 (64.3 %)
 

Endovascular therapy*

4 (50.0 %)

32 (9 %)
 

None


 

Timing of occlusion therapy

Mean value (days from SAH ± SD)

4.5 ± 4.5

3.8 ± 5.7

p = 0.445b

Mean value (days from admission ± SD)

1.6 ± 1.6

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Nov 8, 2016 | Posted by in NEUROLOGY | Comments Off on of Patients Without Neuropsychological Deficits Following Aneurysmal Subarachnoid Haemorrhage

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