Patients without NPD
Patients with NPD
p value
Age
Mean value (years ± SD)
51.9 ± 11.8
51.4 ± 11.6
p = 0.718a
Women/men ratio
1:1
1.7:1
p = 0.705b
Admission scores
GCS (median)
15.00
14.00
p = 0.012a
WFNS (median)
1.00
2.00
p = 0.011a
Fisher (median)
2.00
3.00
p = 0.001a
Aneurysm bearing artery
Acom + ACA
3 (37.5 %)
38 (45.2 %)
MCA
2 (25.0 %)
22 (26.2 %)
ICA + Pcom
3 (37.5 %)
14 (16.7 %)
Vertebrobasilar
–
10 (11.9 %)
Aneurysm location
p = 0.591b
Anterior circulation
8 (100 %)
74 (88.1 %)
Posterior circulation
–
10 (11.9 %)
Aneurysm size
Mean value (mm ± SD)
6.3 ± 2.0
6.5 ± 2.6
p = 0.817a
Table 2 shows information on the clinical course and the treatment performed in patients of both study groups. Acute hydrocephalus requiring CSF diversion was associated with neuropsychological morbidity after discharge (p = 0.009). Aneurysm occlusion was performed within 72 h after haemorrhage, whenever feasible. A total of 58 aneurysms were clipped and 36 aneurysms were occluded using endovascular techniques (including 34 coiling procedures; one stent-assisted coiling and one aneurysm was primarily stented). Patients without NPD were distributed equally between the two modalities of aneurysm therapy (p = 0.706). No patient with regular neuropsychological outcome required shunt surgery for chronic hydrocephalus (p = 0.019). Two of 12 patients who required decompressive hemicraniectomy (DHC) for elevated intracranial pressure (ICP) refractory to maximal conservative therapy showed no NPD at the follow-up (p = 0.590). Patients without NPD showed a tendency towards a lower rate of CVS (12.5 vs. 45.2 %; p = 0.131) and none developed DCI (0 vs. 33.3 %; p = 0.100). Patients with regular neuropsychological outcome were discharged significantly earlier than patients with cognitive constraint (p < 0.001).
Table 2
Information on the clinical course and the treatment performed in patients of both study groups
Patients without NPD | Patients with NPD | p value | |
---|---|---|---|
ICP – therapy/CSF – diversion | |||
EVD/lumbar drain placement | 1 (12.5 %) | 52 (61.9 %) | p = 0.009a |
Shunt placement | – | 38 (45.2 %) | p = 0.019a |
DHC | 2 (25.0 %) | 10 (11.9 %) | p = 0.590a |
Aneurysm treatment | p = 0.706a | ||
Microsurgical clipping | 4 (50.0 %) | 54 (64.3 %) | |
Endovascular therapy* | 4 (50.0 %) | 32 (9 %) | |
None | – | – | |
Timing of occlusion therapy | |||
Mean value (days from SAH ± SD) | 4.5 ± 4.5 | 3.8 ± 5.7 | p = 0.445b |
Mean value (days from admission ± SD) | 1.6 ± 1.6
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