OSA in the Morbidly Obese and the Effect of Weight Loss on OSA Severity


Characteristics

Mean ± SD

Age (years)

47.2 ± 9.4

BMI

45.5 ± 7.3

Neck circumference (cm)

43.5 ± 4.8


BMI body mass index, SD standard deviation



Table 2 shows the polysomnographic results. Thirty-four percent (55 patients) had POSA. This was found to be significantly lower (p < 0.001) compared to the 53 % prevalence reported in the literature [5]. When comparing positional versus non-positional patients, BMI, neck circumference, and AHI were significantly different among these groups. Positional patients had a significantly lower BMI and neck circumference, and the AHI was lower in this group (Table 3).


Table 2
Polysomnographic results






















Characteristics

Mean ± SD

Total AHI

31.5 ± 30.1

Desaturation index

31.4 ± 28.6

Sleep efficiency (%)

83.2 ± 11.0

Total sleep time (min)

420.8 ± 87.0


AHI apnea-hypopnea index, SD standard deviation



Table 3
Comparison of demographics between positional and non-positional OSA patients before bariatric surgery





































Characteristics

Positional OSA (n = 55, 34.0 %)

Non-positional OSA (n = 107, 76.0 %)

Mann–Whitney (p-value)

Mean ± SD

Mean ± SD

Age (years)

46.00 ± 9.38

47.79 ± 9.40

 0.265

BMI

43.04 ± 5.66

46.71 ± 7.70

 0.001

Neck circumference (cm)

41.85 ± 3.75

44.28 ± 5.01

 0.006

Total AHI

19.26 ± 15.42

37.82 ± 33.69

<0.001


AHI apnea-hypopnea index, SD standard deviation, OSA obstructive sleep apnea



Changes Following Bariatric Surgery


Of the 162 patients who underwent surgery, 43 patients were lost to follow-up or failed to obtain a postoperative PSG. Twenty-eight patients were excluded because they did not meet the inclusion criteria following surgery. In the remaining 91 patients, pre- and postsurgery PSG results were compared. There was an average follow-up interval of 7 months (SD ± 2.0) for PSG recording after surgery. Table 4 summarizes the comparison of both demographic and PSG results before and after surgery. A significant decrease in BMI, neck circumference, total AHI, and desaturation index is seen following surgery with an associated increase in sleep efficiency. These parameters were all improved after bariatric surgery. When looking specifically at BMI after surgery, 88 patients had a decrease of at least 1 point in their BMI, 2 patients had no change, and 1 patient had an increase in BMI. Regression analysis showed that only a low AHI was a significant independent predictor for POSA (p = 0.001). The Hosmer and Lemeshow Goodness-of-Fit test confirmed the model to be a good fit.


Table 4
Comparison of pre- and post-bariatric surgery results






















































Characteristics

Frequency (%)

Pre-BS (mean ± SD)

Post-BS (mean ± SD)

Wilcoxon signed ranks (p-value)

Gender

 Male

18 (19.8)
     

 Female

73 (80.2)
     

BMI
 
45.2 ± 6.7

36.0 ± 5.8

<0.001

Neck circumference (cm)
 
43.1 ± 4.4

39.5 ± 4.0

<0.001

Total AHI
 
29.6 ± 27.1

10.3 ± 10.5

<0.001

Desaturation index
 
27.7 ± 26.0

9.5 ± 9.1

<0.001

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Oct 17, 2016 | Posted by in PSYCHIATRY | Comments Off on OSA in the Morbidly Obese and the Effect of Weight Loss on OSA Severity

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