Parasomnias in Adolescents


Features

Strongly favoring parasomnias

Moderately favoring parasomnias

Do not discriminate between parasomnias and NFLE

External (noise) or internal (cough, snore) trigger

+
  
Duration of the event

>2 min
 
Brevity

Pattern

Waxing/waning

Variability/absence of stereotypy
 
Behavior

Sobbing

Semi-purposeful, fumbling, manipulation of nearby objects

Fearful emotional

Sad emotional

Manifestations

Yawning

Coughing
 
Scratching

Prominent nose-rubbing

Motor activity

Rolling over the bed

Tremor/trembling

Sitting

Myoclonic jerks

Standing/walking

Physical and verbal interaction

+
  
Offset of event

Failure to fully arouse after event even with complex behavior
  
Indistinct offset

Recorded events during PSG

Discordance between severity and duration of reported event and recorded event

No events recoding during the 1st night

Brief arousals (up to 10 s) without definite semiological features of epilepsy

Few events recorded in total (<3)





 

  • 2.


    Night terrors

    Sleep terrors (ST) , also known as night terrors or pavor nocturnus, are conditions characterized by a sudden and unexpected arousal from stage N3, with an abrupt scream and behavioral manifestations of intense fear. They are associated with intense autonomic and motor symptoms, such as crying or screaming. These events can be dramatic and disturbing to the family, yet the patient may be unfazed by the events. The child cannot be consoled or woken and typically has a partial or complete amnesia of the episodes the next day [1, 47]. Prevalence of ST varies with age from 6.5 % in children to 1 % in the elderly [31].

     

  • 3.


    Sleepwalking

    Sleepwalking (SW ) is an arousal disorder culminating in walking around in an altered state with impaired judgment. Sleepwalking occurs most often out of stage N3 sleep and during the first third of the night. SW is an expression of simultaneously activated states of (partial) sleep and (partial) wakefulness, a complex dissociated state, with clinical consequences [48]. Prevalence in childhood is as high as 17 %, with a peak age at 12 years. Sleepwalking typically decreases in frequency until adulthood, but 3 % of adults continue to sleepwalk [49]. SW needs to be differentiated from nocturnal seizures. Safety and legal implications have to be addressed. It is important to make the bedroom as safe as possible to minimize the risk of injury, by sleeping on the ground floor, removing obstructions in the bedroom, and closing doors and windows [50]. Sometimes, SW can become crippling because of its frequency (several times a week or a night), because of the risks associated with the behavior (going outside, manipulating sharp objects, etc.), or violence (throwing objects, using weapons, etc.) or because of its consequences on everyday quality of life (sleepiness, fatigue, insomnia, anxiety, and depressive symptoms). In these situations, treatment is required (Fig. 6.1). These include sleep hygiene, securing the environment for safety, reduction of alcohol consumption, and treatments of precipitating factors like OSA, PLMS , or anxiety that could exacerbate episodes. No large controlled trials of drugs have been conducted in SW. Tricyclic antidepressants or benzodiazepines can be used as good treatment options. If pharmacological approaches are warranted, regular follow-up is recommended to determine continued need for management and then to safely taper or discontinue the medication in a manner that will not result in withdrawal.

    A371015_1_En_6_Fig1_HTML.gif


    Fig. 6.1
    Diagnostic approach and treatment options for sleepwalking. SW sleepwalking, PSG polysomnography, OSAS obstructive sleep apnea syndrome, RDB REM sleep behavior disorder, NFLE nocturnal frontal lobe epilepsy

    Psychotherapy may also be initiated to improve anxiety and sometimes insomnia [51].

     





      Pitfalls






      • Neither RBD, nor arousal disorders (ADs) may manifest during a single overnight polysomnographic (PSG) study in the sleep laboratory.


      • The role of alcohol is controversial. It is questionable whether an individual who is heavily intoxicated claims to have been sleepwalking.


      Learning Points






      • All patients with disabling frequent SW should have a polysomnography in order to confirm the sudden awakenings from slow-wave sleep with abnormal behaviors and exclude differential diagnosis such as nocturnal epilepsy or REM sleep behavior disorder.


      • Disorders of arousal associated with violence should always be investigated and adequately treated. Full neuropsychological or psychiatric assessment may be necessary, especially if there is a medico-legal issue at stake.


      • All factors inducing an increase of slow-wave sleep and sleep fragmentation can thus increase the frequency of the episodes. Patients should be encouraged to have regular sleep schedules and to avoid sleep deprivation.

      Sleepwalkers report a clear association between the occurrence and the severity of sleepwalking episodes and their alcohol consumption.



      Disclosure

      None of the authors have any financial support or conflicts of interest to disclose.

      No off-label use of drugs or products has been discussed in the manuscript.


      References



      1.

      American Sleep Disorders Association. International classification of sleep disorders, Third Edition (ICSD-3) Revised: Diagnostic and Coding Manual. Rochester, MN: American Sleep Disorders Association; 2014.


      2.

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      Schenck CH. Rapid eye movement sleep behavior disorder: current knowledge and future directions. Sleep Med. 2013;14(8):699–702.CrossRefPubMed


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      Budhiraja R. The man who fought in sleep. J Clin Sleep Med. 2007;3(4):427–8.PubMedPubMedCentral


      5.

      Kolla BP, Mansukhani MP. Antidepressants trigger an early clinical presentation of REM sleep behavior disorder: the jury is still out. Sleep. 2014;37(8):1393.PubMedPubMedCentral


      6.

      Postuma RB, Gagnon JF, Tuineaig M, et al. Antidepressants and REM sleep behavior disorder: isolated side effect or neurodegenerative signal? Sleep. 2013;36(11):1579–85.PubMedPubMedCentral


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      Boeve BF. REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder- neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci. 2010;1184:15–54.CrossRefPubMedPubMedCentral

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    1. Sep 23, 2017 | Posted by in NEUROLOGY | Comments Off on Parasomnias in Adolescents

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