43 Pharmacology – 1
| T | F | |
|---|---|---|
| 1. Chronic administration of agonists results in both receptor desensitization and down-regulation. |  |  |
| 2. Antagonists bind with agonists and prevent them reaching the receptors. |  |  |
| 3. The area under the curve is greater if the drug elimination is faster. |  |  |
| 4. In zero-order kinetics the rate of elimination is directly proportional to the amount of drug remaining. |  |  |
| 5. Second messengers are characteristic of ion-channel receptors. |  |  |
| 6. Therapeutic index is the ratio of the maximum tolerated concentration and the minimum effective concentration. |  |  |
| 7. The binding of two acetylcholine molecules at the two beta subunits of a nicotinic receptor-channel results in the opening of that channel. |  |  |
| 8. Albumin has a low affinity for acidic drugs. |  |  |
| 9. D-Cycloserine enhances the extinction of fear. |  |  |
| 10. Dopamine neurons that innervate the nucleus accumbens have their cell bodies in the ventral tegmental area of the midbrain. |  |  |
| 11. Lithium decreases dopaminergic effects in the CNS. |  |  |
| 12. Bromocriptine decreases dopaminergic effects in the CNS. |  |  |
| 13. D1 and D2 receptors belong to the same family. |  |  |
| 14. Endorphins are implicated in the gate theory of pain. |  |  |
| 15. Glutamate is an NMDA antagonist. |  |  |
| 16. Melatonin has a narrow therapeutic index. |  |  |
| 17. Nicotinic receptors control cation channels. |  |  |
| 18. Nicotine improves cognitive performance in non-smokers. |  |  |
| 19. Nicotinic receptors are ligand-gated. |  |  |
| 20. Noradrenaline reuptake inhibitors increase the sensitivity of presynaptic α2-receptors. |  |  |
| 21. The QT interval is dependent on heart rate. |  |  |
| 22. 5-HT1A receptors are called 5-HTB receptors. |  |  |
| 23. Some serotonin receptors are metabotropic while others are ionotropic. |  |  |
| 24. 5-HT3 receptor is ionotropic. |  |  |
| 25. Substance P antagonists reduce pain. |  |  |
