The management of patients with cerebrovascular disease has become complex given the severity of concomitant medical comorbidities. An understanding of the clinical indication and pharmacological basis for stroke therapeutics is critical. Many of these treatments are initiated by neurologists shortly after an acute stroke for prompt secondary prevention. Additionally, many vascular neurologists will oversee therapeutics used to treat thrombosis, hypertension , and hyperlipidemia in the outpatient setting along with cardiologists and internists.