Author
Surgical procedure
Sample size
Age at onset
Age at surgery
Study age
Outcome measures
Seizure outcome
Summary of results
Follow-up interval
1. Kim et al. [12]
Not specified
19 surgery
21 no surgery
20 control
Not reported
Not reported
Surgery: 26.8
Control: 26.5
Korean version of QOLIE-89
Not reported
Individuals in surgery and no-surgery groups reported lower scores overall as compared to controls.
The surgery group had improved postop QOL scores.
Pre-surgery and >3 mo. postop evaluation
2. Vickrey et al. [7]
Anterior temporal lobectomy (n = 175)
Extratemporal lobectomy (n = 22)
202 surgery
46 no surgery
Surgery: 11.9 years
No surgery: 12 years
Not reported
Surgery: 27 years
No surgery:
26 years
ESI-55 (at follow-up only)
Employment
KAS
AEDs
Seizure outcome
Surgery: 60 % SF (no seizures, auras or 1 seizure)
No surgery: 11 % SF
The surgery group scored significantly higher on 5 of 11 scales (seizure health perception, social function, pain, role limitations caused by physical problems and role limitations caused by emotional problems).
Pre-surgery, 5.8 years for surgery
5.7 years for no surgery
3. Kellet et al. [8]
48 % Anterior temporal lobectomy
25 % Amygdalohippocampectomy
18 % Temporal lesionectomy
9 % Extratemporal resection
94 surgery
36 no surgery
Surgery: 11.7 years
No surgery: 12.4 years
Not reported
Surgery: 33.1 years
No surgery: 33.6 years
Overall QOL
Overall health
Impact of epilepsy
AEDs
Seizure frequency
Surgery satisfaction
Stigma
Mastery
Anxiety
Self-esteem
Depression
Affect balance
Employment or education
HRQOL model (Baker et al. [47])
Surgery: 47.9 % in the past year. (auras counted as seizures).
QOL outcomes were significantly better for SF group post-surgery than those with continuous seizures and the no-surgery group.
QOL improved for participants with less frequent seizures, but to a lesser degree.
1986–1994 (years included in follow-up)
No interval given.
4. McLachlan et al. [28]
Temporal lobectomy
51 surgery
21 no surgery
Surgery: 12.1 years
No surgery: 17 years
Not reported
Surgery: 31.9 years
No surgery: 34.2 years
(baseline)
ESI-55
Surgery: 88 % >90 % reduction or SF
Nonsurgery: 8 % >90 % reduction or SF
(2-yr follow-up)
SF group and participants with at least 90 % seizure reduction improved in QOL post-surgery.
This improvement was most evident at 2-yr follow-up.
QOL deteriorated with < 90 % seizure reduction.
Pre-surgery, 6, 12, and 24 months
5. Gilliam et al. [16]
Anterior temporal lobectomy
125 surgery
71 waitlist control
Surgery: 12.3 years
Waitlist: 14 years
Surgery: 31 years
Wait-list: 33 years
Not reported
ESI-55
POMS
Driving
Employment/school
AEDs
Seizure frequency
Adverse events profile
Surgery: 65 % SF
(no seizures or only auras)
Surgery group had better QOL scores in 8 or 11 scales.
SF status and IQ not associated with better QOL.
Mood status, employment, driving and AED cessation were associated with better QOL.
12 and 24 months
6. Markand et al. [20]
Anterior temporal lobectomy
53 surgery
37 no surgery
Surgery: 12.3 years
No surgery: 13.4 years
Not reported
Surgery: 31 years
No surgery: 36.9 year
(baseline)
QOLIE-89
Surgery: 73.6 % SF
No surgery: 0 % SF
(Engel classification)
Overall QOL score and 10 of 17 scale scores improved in surgery group and was related to SF status
Pre-surgery, 1 and 2 years
7. Helmstaedter et al. [30]
Temporal lobectomy
147 surgery
120 no surgery
Surgery: 12 years
No
surgery: 17 years
Not reported
Surgery: 31 years
No
surgery:
35 years
QOLIE-10
VLMT
DCS-R
Employment or school
BDI
Surgery: 63 % SF
No surgery: 12 % SF
Seizure free improvement of non-memory functions in T1-T2 and improvement of memory in T2-T3
Seizure free less impaired QOLIE-10 scores and less depression
Pre-surgery, 1 year and 2–10 years
8. Aydemir et al. [29]
Temporal lobectomy
21 surgery
20 pre-surgery
Surgery: 8 years
Pre-surgery: 6.3 years
Not reported
Surgery: 27 years
Pre-surgery: 24.8 years
SF-36
BDI
STAI
Stigma
Perceived impact of epilepsy
Opinions on epilepsy and surgery
Surgery: 47.6 % SF
QOL of post-surgery was better than scores before surgery
6 months to 4 years Average 27 months
9. Bien et al. [15]
Temporal lobectomy
131 surgery
105 waitlist control
99 presurgical candidates
49 no surgery
Not reported
Not reported
Surgery: 31.1 years
Waitlist: 35.8 years
Presurgical: 31.9 years
No surgery: 36.6 years
ESI-55
Seizure questionnaire
AEDs
Surgery: 52 % SF
Waitlist: 5 % SF
Presurgical: 14 % SF
No surgery: 24 % SF
QOL scores of SF higher than those who were not SF
Minimum 1 year
10. Mikati et al. [9]
75 % Temporal lobectomy
25 % Extratemporal resections
20 surgery
17 no surgery
20 controls
Surgery: 9.3 years
No surgery: 14.82 years
Not reported
Surgery: 30.5 years
No surgery: 31.5 years
Control: 29.2 years
ESI-55
Surgery: 85 % SF
No surgery: 35 % SF
(Engel classification)
QOL was significantly better in surgery group than in nonsurgery group and reached similar levels to healthy controls at 3-year follow-up
3 years
11. Stavem et al. [14]
Resective surgery for focal epilepsy
70 surgery
70 matched controls
Surgery: 9.4 years
No surgery: 9.6 years
Surgery: 24 years
Surgery: 37 years
No surgery: 37 years
QOLIE-89
Surgery: 48 % SF
No surgery: 19 % SF
Surgery patients had higher HRQOL scores than nonsurgery patients
Average 15 years
12. McGlone et al. [11]
Anterior temporal lobectomy (n = 8)
Amygdalohippocampectomy (n = 1)
Hemispherectomy (n = 1)
16 VNS, 10 surgery
9 no surgery
Not reported
Not reported
VNS: 35 years
Surgery: 36 years
No surgery: 37 years
QOLIE-89
GDS
WMS, MOQ
Not reported
QOL improved more in surgery group than in VNS or medically managed group
Pre-surgery and 1 year
13. Choi-Kwon et al. [17]
Anterior temporal lobectomy (n = 22)
Other (n = 10)
32 surgery
32 no surgery
Not reported
Not reported
Surgery: 30.6 years
No surgery: 31.4 years
Korean ESI-55
Seizure outcome
AEDs
Seizure stigma
Korean version of HADS
Surgery: 84 % SF
No surgery: 45 % SF (2-yr follow-up)
QOL improved in surgery group but not in nonsurgery group. At 6 months, SF was an important factor in QOL, while at 2 years, AEDs and depression were important
Pre-surgery, 6 months and 2 years
14. Engle et al. [5]
Temporal lobectomy
15 surgery
23 no surgery
Not reported
Not reported
Surgery: 37.5 years
No surgery: 30.9 years
(baseline)
QOLIE-89
QOLIE AD-48
Seizure outcome
Surgery: 73 % SF
No surgery: 0 % SF
QOL scores were higher in the surgery group than the no-surgery group, but this difference was not significant
Pre-surgery, and every 3 months for 2 years
15. Kanchanatawan [13]
Not specified
60 surgery
60 no surgery
Not reported
Not reported
Surgery: 36.1 years
No surgery: 29.3 years
Thai version of WHOQOL-BREF-26
Thai version of HDRS
Surgery: 66.7 % SF
No surgery: 5 % SF
Surgery group had better QOL scores than nonsurgery group and had similar QOL scores compared to the general Thai population
Minimum 1 year
16. Fiest et al. [6]
Temporal lobectomy
40 surgery
40 no surgery
Surgery: 14.3 years
No surgery: 16.2 years
Not reported
Surgery: 35.5 years
No surgery: 34.4 years
(baseline)
QOLIE-89
QOLIE-31
SF-36
HUI-III
GHQ
Surgery: 38 % SF
No surgery: 3 % SF
More surgery group had meaningful improvement in QOL than nonsurgery group.
No surgery group had worsening of QOL at follow-ups
Pre-surgery, 6 and 12 months
17. Taft et al. [10]
Temporal lobectomy (n = 80)
Frontal lobectomy (n = 12)
Parietal lobectomy (n = 1)
Multilobe resection (n = 1)
Hemispherectomy (n = 1)
Multiple subpial transection (n = 1)
96 surgery
45 no surgery
Not reported
Not reported
Surgery: Median
33 years
No surgery:
Median
33 years (baseline)
SF-36
Seizure freedom
HADS
Surgery satisfaction
Surgery: 55 % SF
No surgery: 11 % SF (ILAE
classification)
QOL scores of SF surgery group reached norm at follow-up except in social functioning
No change in not SF groups
Pre-surgery and average 2 years follow-up
