Receptors and Attention




Heishman SJ, Kleykamp BA, Singleton EG (2010) Meta-analysis of the acute effects of nicotine and smoking on human performance. Psychopharmacology 210:453–469PubMedCentralPubMed


Hong LE, Schroeder M, Ross TJ, Buchholz B, Salmeron BJ, Wonodi I et al (2011) Nicotine enhances but does not normalize visual sustained attention and the associated brain network in schizophrenia. Schizophr Bull 37:416–425PubMedCentralPubMed


Howe WM, Ji J, Parikh V, Williams S, Mocaer E, Trocme-Thibierge C et al (2010) Enhancement of attentional performance by selective stimulation of alpha4beta2(*) nAChRs: underlying cholinergic mechanisms. Neuropsychopharmacology 35:1391–1401PubMedCentralPubMed


Hoyle E, Genn RF, Fernandes C, Stolerman IP (2006) Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Psychopharmacology 189:211–223PubMedCentralPubMed


Hurst R, Rollema H, Bertrand D (2013) Nicotinic acetylcholine receptors: from basic science to therapeutics. Pharmacol Ther 137:22–54PubMed


Jacobsen LK, Gore JC, Skudlarski P, Lacadie CM, Jatlow P, Krystal JH (2002) Impact of intravenous nicotine on BOLD signal response to photic stimulation. Magn Reson Imaging 20:141–145PubMed


Jacobsen LK, D’Souza DC, Mencl WE, Pugh KR, Skudlarski P, Krystal JH (2004) Nicotine effects on brain function and functional connectivity in schizophrenia. Biol Psychiatry 55:850–858PubMed


Jones GM, Sahakian BJ, Levy R, Warburton DM, Gray JA (1992) Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer’s disease. Psychopharmacology 108:485–494PubMed


Jones KM, McDonald IM, Bourin C, Olson RE, Bristow LJ, Easton A (2014) Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats. Psychopharmacology 231:673–683PubMed


Juliano LM, Fucito LM, Harrell PT (2011) The Influence of nicotine dose and nicotine dose expectancy on the cognitive and subjective effects of cigarette smoking. Exp Clin Psychopharmacol 19:105–115PubMedCentralPubMed


Kelly AM, Uddin LQ, Biswal BB, Castellanos FX, Milham MP (2008) Competition between functional brain networks mediates behavioral variability. Neuroimage 39:527–537PubMed


Kendziorra K, Wolf H, Meyer PM, Barthel H, Hesse S, Becker GA et al (2011) Decreased cerebral a4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer’s disease assessed with positron emission tomography. Eur J Nucl Med Mol Imaging 38:515–525PubMed


Kenney JW, Gould TJ (2008) Modulation of hippocampus-dependent learning and synaptic plasticity by nicotine. Mol Neurobiol 38:101–121PubMedCentralPubMed


Knott V, Bosman M, Mahoney C, Ilivitsky V, Quirt K (1999) Transdermal nicotine: Single dose effects on mood, EEG, performance, and event-related potentials. Pharmacol Biochem Behav 63:253–261PubMed


Knott V, Millar A, Fisher D, Albert P (2010a) Effects of nicotine on the amplitude and gating of the auditory P50 and its influence by dopamine D2 receptor gene polymorphism. Neuroscience 166:145–156PubMed


Knott VJ, Fisher DJ, Millar AM (2010b) Differential effects of nicotine on P50 amplitude, its gating, and their neural sources in low and high suppressors. Neuroscience 170:816–826PubMed


Knott VJ, Millar AM, McIntosh JF, Shah DK, Fisher DJ, Blais CM et al (2011) Separate and combined effects of low dose ketamine and nicotine on behavioural and neural correlates of sustained attention. Biol Psychol 88:83–93PubMed


Koelega HS (1993) Stimulant drugs and vigilance performance: a review. Psychopharmacology 111:1–16PubMed


Kumari V, Gray JA, ffytche DH, Mitterschiffthaler MT, Das M, Zachariah E et al (2003) Cognitive effects of nicotine in humans: an fMRI study. Neuroimage 19:1002–1013PubMed


Lawrence NS, Ross TJ, Stein EA (2002) Cognitive mechanisms of nicotine on visual attention. Neuron 36:539–548PubMed


Leiser SC, Bowlby MR, Comery TA, Dunlop J (2009) A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits. Pharmacol Ther 122:302–311PubMed


Leonard S, Gault J, Hopkins J, Logel J, Vianzon R, Short M et al (2002) Association of promoter variants in the alpha 7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry 59:1085–1096PubMed


Lerman C, Audrain J, Tercyak K, Hawk LW Jr, Bush A, Crystal-Mansour S et al (2001) Attention-deficit hyperactivity disorder (ADHD) symptoms and smoking patterns among participants in a smoking-cessation program. Nicotine Tob Res 3:353–359PubMed


Levin ED (1992) Nicotinic systems and cognitive function. Psychopharmacology 108:417–431PubMed


Levin ED, Caldwell DP (2006) Low-dose mecamylamine improves learning of rats in the radial-arm maze repeated acquisition procedure. Neurobiol Learn Mem 86:117–122PubMed


Levin ED, Rezvani AH (2002) Nicotinic treatment for cognitive dysfunction. Curr Drug Targets CNS Neurol Disord 1:423–431PubMed


Levin ED, Conners CK, Sparrow E, Hinton SC, Erhardt D, Meck WH et al (1996) Nicotine effects on adults with attention-deficit/hyperactivity disorder. Psychopharmacology 123:55–63PubMed


Levin ED, Conners CK, Silva D, Hinton SC, Meck WH, March J et al (1998) Transdermal nicotine effects on attention. Psychopharmacology 140:135–141PubMed


Levin ED, Cauley M, Rezvani AH (2013) Improvement of attentional function with antagonism of nicotinic receptors in female rats. Eur J Pharmacol 702:269–274PubMedCentralPubMed


Lieberman JA, Dunbar G, Segreti AC, Girgis RR, Seoane F, Beaver JS et al (2013) A randomized exploratory trial of an alpha-7 nicotinic receptor agonist (TC-5619) for cognitive enhancement in schizophrenia. Neuropsychopharmacology 38:968–975PubMedCentralPubMed


Lindgren M, Stenberg G, Rosen I (1998) Effects of nicotine in a bimodal attention task. Neuropsychobiology 38:42–49PubMed


Lopez E, Arce C, Vicente S, Oset-Gasque MJ, Gonzalez MP (2001) Nicotinic receptors mediate the release of amino acid neurotransmitters in cultured cortical neurons. Cereb Cortex 11:158–163PubMed


Loughead J, Ray R, Wileyto EP, Ruparel K, Sanborn P, Siegel S et al (2010) Effects of the alpha 4 beta 2 partial agonist varenicline on brain activity and working memory in abstinent smokers. Biol Psychiatry 67:715–721PubMed


Lukas RJ, Changeux J-P, Le Novere N, Albuquerque EX, Balfour DJK, Berg DK et al (1999) International union of pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 51:397–401PubMed


Macallan DR, Lunt GG, Wonnacott S, Swanson KL, Rapoport H, Albuquerque EX (1988) Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems. FEBS Lett 226:357–363PubMed


MacDermott AB, Role LW, Siegelbaum SA (1999) Presynaptic ionotropic receptors and the control of transmitter release. Annu Rev Neurosci 22:443–485PubMed


Mackworth NH (1950) Researches on the measurement of human performance. Medical Research Council, Special report series 268. His Majesty’s stationary office, London, p 156


Mahncke HW, Bronstone A, Merzenich MM (2006) Brain plasticity and functional losses in the aged: scientific bases for a novel intervention. Reprogram Brain 157:81–109


Mancuso G, Warburton DM, Melen M, Sherwood N, Tirelli E (1999) Selective effects of nicotine on attentional processes. Psychopharmacology 146:199–204PubMed


Mancuso G, Lejeune M, Ansseau M (2001) Cigarette smoking and attention: processing speed or specific effects? Psychopharmacology 155:372–378PubMed


Mangan GL, Golding JF (1983) The effects of smoking on memory consolidation. J Psychol 115:65–77PubMed


Mansvelder HD, Keath JR, McGehee DS (2002) Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron 33:905–919PubMed


Mansvelder HD, van Aerde KI, Couey JJ, Brussaard AB (2006a) Nicotinic modulation of neuronal networks: from receptors to cognition. Psychopharmacology 184:292–305PubMed


Mansvelder HD, van Aerde KI, Couey JJ, Brussaard AB (2006b) Nicotinic modulation of neuronal networks: from receptors to cognition. Psychopharmacology 184:292–305PubMed


Martin LF, Freedman R (2007) Schizophrenia and the alpha 7 nicotinic acetylcholine receptor. Integr Neurobiol Schizophr 78:225–246


Martin LF, Kem WR, Freedman R (2004) Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology 174:54–64PubMed


Martin LF, Davalos DB, Kisley MA (2009) Nicotine enhances automatic temporal processing as measured by the mismatch negativity waveform. Nicotine Tob Res 11:698–706PubMed


McGaughy J, Sarter M (1995) Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands. Psychopharmacology 117:340–357PubMed


McGaughy J, Decker MW, Sarter M (1999) Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology 144:175–182PubMed


McLean SL, Idris NF, Grayson B, Gendle DF, Mackie C, Lesage AS et al (2012) PNU-120596, a positive allosteric modulator of alpha7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. J Psychopharmacol 26:1265–1270PubMed

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Nov 10, 2016 | Posted by in NEUROLOGY | Comments Off on Receptors and Attention

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