Self-Harm in Adolescents


Psychological function

Examples

Affect regulation

“To manage stress,” “to stop bad feelings”

Self-punishment

“To punish myself,” “to express anger at myself”

Anti-dissociation

“To stop feeling numb,” “to feel real and alive”

Anti-suicide

“To prevent me from acting on suicidal thoughts”

Interpersonal influence

“To get help,” “to get my parents to stop fighting,”“to get people to leave me alone”

Sensation-seeking

“To get a rush,” “thought it would be fun”

Interpersonal boundaries

“It’s something that only I have control of”



For many individuals with DSH behaviors, the behaviors may have different functions over time and in different circumstances (Lloyd-Richardson, 2008). Another important part of DSH for some people can be seeing blood, which may help to achieve the desired effect such as relieving tension. In a study of college students, 51.6 % of the students, all with DSH behaviors, reported that it was important to see blood with DSH (Glenn & Klonsky, 2010). The study results also supported that in general those that felt it was important to see blood represented a clinically more severe group.



Pathophysiology of DSH


Looking at the brain processing of pain and emotional distress, and considering the neurodevelopmental changes happening in adolescence, may help clinicians better understand DSH.


Overlap of Physical and Social Pain


Pain sensation is an incredibly complex process that includes sensory and emotional components, with major overlap in brain areas that process physical and emotional/social pain (Ballard et al., 2010). Functional imaging studies comparing healthy adolescents and adults show differential activation of brain areas involved in the experience of social pain. It is possible that adolescents experience social pain differently and perhaps more severely than adults.


The Role of Neurodevelopment


Neuroanatomical brain changes continue throughout adolescence into young adulthood and possibly contribute to increased vulnerability of adolescents to DSH. One of the best characterized changes continuing throughout adolescence is the volume of gray matter over time (Ballard et al., 2010). Gray matter volume (density of neurons) increases until age 11–12 and then declines until young adulthood. This change proceeds in back-to-front direction, with the prefrontal cortex (reasoning, modulating emotional urges) being the last anatomic region of the brain to reach an “adult” pattern of gray matter changes. This maturation correlates with improved impulse control, planning, and emotional regulation.

Many other changes occur during adolescence outside of the brain that directly influence behavior. The hypothalamic-pituitary-adrenal (HPA) axis, a system that is key to the body’s response to stress, appears to be more “sensitive” in adolescents (Ballard et al., 2010). Stressors cause a greater release of stress hormones (particularly cortisol) via the HPA system in younger people. Cortisol has effects throughout the body and brain.


The Opioid-Deficit Model


Opioids are naturally occurring (endorphins) and man-made chemicals (e.g., morphine) that have been primarily studied for the treatment of pain. However, growing evidence shows an important role of endogenous opioids in emotion regulation and social behavior. The “opioid-deficit model” is an explanatory hypothesis for DSH in BPD (Fikke, Melinder & Landrø, 2011; Stanley et al., 2010).

The opioid-deficit model has various supporting evidence. Self-harming patients often report self-cutting as a non-painful, non-suicidal act accompanied by a sense of relief or well-being. The opioid-deficit model postulates that people engaging in repeated DSH have abnormally low opioid effect and cutting causes release of endogenous opioids bringing the patient to a “normal” level. DSH could be seen in this light as self-medication. It has long been noted that among adults with BPD, there is a high rate of exogenous opioid abuse and reports of BPD patients who take opiates report feeling “normal” rather than “high.”

A study by Prossin et al. examined opioid receptor activity in the cerebral cortex of patients during various moods using positron emission tomography (PET) scanning (Prossin, Love, Koeppe, Zubieta, & Silk, 2010). Unmedicated female BPD patients were studied versus matched healthy controls during both a “neutral” mood and “induced sadness.” During the neutral mood, there was greater baseline opioid receptor availability in BPD patients relative to comparison subjects. They hypothesize that greater receptor availability may occur because of lower baseline endogenous opioid neurotransmitter activity in BPD patients. During induced sadness, BPD patients showed greater activation of the endogenous opioid system in many parts of the brain compared to controls. These imaging findings correlate with the clinical findings that BPD patients have a low threshold for becoming emotionally dysregulated, followed by a rise to high levels of emotional arousal.

Stanley et al. researched levels of endogenous neurotransmitters and endogenous opioids in the cerebral spinal fluid (CSF) in adult patients with repetitive DSH versus controls. All study participants were diagnosed with a cluster B personality disorder (all but three had BPD) and had a history of at least one suicide attempt. Of the 29 total patients, 14 had a history of repeated DSH and 25 did not. CSF was collected from all participants via lumbar puncture in the morning after a night of at least 8 h of strict bedrest. The following were measured in all patients: three types of endogenous opioids, the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the dopamine metabolite homovanillic acid (HVA). The DSH group had significantly lower levels of two of the three measured opioids. There were no differences in CSF dynorphin, 5-HIAA, and HVA levels between the groups. Also worth noting is that the DSH group reported a higher level of depression and hopelessness.

Extrapolating from both the Prossin and Stanley studies to adolescents has many limitations as the study participants were older in age, had longer lasting illness, mainly included women, and used BPD as a model for studying DSH. However these studies combined with others support opioid system abnormalities in DSH. Further research focusing specifically on adolescents is much needed.


Executive Brain Function


There has been some investigation into whether executive brain functioning differs in adolescents with DSH behaviors. One study looked at 97 high school students, divided into three groups: low-severity DSH, high-severity DSH, and healthy controls (Fikke et al., 2011). The main areas of executive functioning were tested and some differences between the DSH subgroups and controls were found. Overall, there were working memory deficits noted in the high-severity DSH group, and impaired inhibitory control in the low-severity DSH group.


Association Between SI and Suicide


Suicidality and DSH are both common and overlap; DSH is a marker of increased risk of future suicide attempts. Andover et al. studied DSH and suicidality among 117 psychiatric inpatients (Andover & Gibb, 2010). Two-thirds of the patients reported a history of suicide attempt(s) and 45 % reported a history of DSH, with cutting being the most common method. Patients with a history of DSH were more likely to report a history of attempted suicide, and frequency of DSH was correlated with the number of suicide attempts. Interestingly, after controlling for depressive symptoms, hopelessness, current suicidal ideation, and symptoms of BPD, a history of DSH still remained significantly correlated with a presence/absence of suicide attempts. Also, reported DSH frequency positively correlated with patient perceptions of lethality of suicide attempts.

Another study, by Nock et al., looked at the relationship between DSH and suicide attempts (Nock, Joiner, Gordon, Lloyd-Richardson, & Prinstein, 2006). Data was collected from 89 young adults who were admitted to a psychiatric inpatient unit and had engaged in DSH in the previous 12 months. DSH was associated with suicidality in patients with a longer history of DSH, multiple methods of DSH, and absence of physical pain during DSH.

Similar findings were noted by Whitlock, Muehlenkamp, and Eckenrode (2008). They surveyed college students with the goal of determining possible subtypes of DSH. Based on a survey of 2,101 students, those who reported 11 or more incidents of DSH using three or more forms of self-injury were the most likely to report suicidality. Also of note, almost half of the students with the most frequent and varied DSH reported that DSH was not/is not a problem in their life.

A study of 373 high school students looked for differences between adolescents that self-harm versus those who have a history of both DSH and suicidality (Brausch & Gutierrez, 2010). Students were divided into three groups: no history of DSH, a history of DSH but no suicide attempts, and history of both DSH and suicide attempts. Unsurprisingly, the no-self-harm group reported the lowest level of hopelessness and highest levels of self-esteem. Comparing the two groups with a history of DSH, the no-suicide-attempts group reported lower depression scores, less suicidal ideation, greater parental support, and greater self-esteem than the suicide-plus-DSH group.


Clinical Assessment/Approach


A thorough assessment of DSH behavior is imperative in guiding care and treatment approaches. There are multiple formal assessment tools available including questionnaires such as the Functional Assessment of Self-Mutilation, the Self-Harm Behavior Questionnaire, the Inventory of Statements About Self-Injury, and formal interview tools such as the Self-Injurious Thoughts and Behaviors Interview, and the Suicide Attempt Self-Injury Interview (Gutierrez, Osmann, Barrios, & Kopper, 2001; Klonsky & Glenn, 2009; Linehan, Comtois, Brown, Heard, & Wagner, 2006; Lloyd-Richardson et al., 2007; Nock, Elizabeth, Photos, & Michel, 2007). These tools were largely developed for research purposes and, though not widely used in the clinical setting, can be used clinically and provide guidance on the important elements of a detailed assessment. Below is advice for the initial approach to DSH and an overview of important areas to cover in assessing the behavior.

The initial reaction of a care provider is important. Reactions of shock, disgust, or other intense negative judgments make it less likely that the person engaging in DSH will bring up the behavior in the future and be forthcoming with further details about the behavior. It is recommended that caregivers respond in a low-key, respectful manner (Walsh, 2007). Initial questions such as “What does self-injury do for you?” can help to communicate that you are interested and wanting to gain a better understanding. Attempts to forbid the behavior or quickly “contract for safety” are not helpful. It is not realistic to think that a person who has developed a coping technique can quickly abandon it, without time to work on establishing other coping skills. So the goal will be to establish a long-term therapeutic relationship, in which DSH can be assessed over time and other coping skills can be learned.

Important areas of assessment include a detailed history of DSH, information about recent DSH behaviors, functions of DSH, triggers and consequences of DSH, and screening for suicidality. When taking a detailed history of DSH, it is helpful to explore the age of onset of the behavior, types of injuries, and frequency of DSH, along with the number of wounds typically inflicted, location of the wounds, experience of pain, and the severity of tissue damage. A longer duration of DSH generally portends a more challenging path to alleviating the behavior. And as discussed above, in at least one sample of young adults, greater risk of suicide attempts was associated with a longer history of DSH, use of a greater number of methods, and the absence of physical pain during DSH (Nock et al., 2006).

In gathering information about DSH occurring in the last couple of months, assessing the function of DSH for the individual will be helpful in guiding treatment. Details about the recent frequency of DSH, number of wounds, and the level of tissue damage can help to indicate current level of distress. Also keep in mind that it is rare for individuals to inflict tissue damage requiring stitches or other medical intervention, and that individuals inflicting severe tissue damage may require emergency mental health assessment. Looking at the wounds, with an individual’s permission, may provide more objective information than a verbal description. If the DSH involves carved words, exploring the selection of the particular words can be helpful therapeutically. The location of injury is also important, as most people will injure extremities or the abdomen. Reports of DSH to the eyes, face, genitals, or breasts are red flags for psychotic or trauma-related behavior (Walsh, 2007).

Many aspects of timing can be helpful to clarify. The duration of time it takes for completion of the injury points to the length of time it takes to relieve distress; therefore longer periods of DSH may be more concerning. Also exploring the time of day of DSH may help in the development of replacement activities or changing usual routines to decrease DSH. Keeping track of the longest time period between DSH can be motivating for some patients, helping them push themselves to achieve longer and longer DSH-free periods. Other key pieces of information to obtain about recent DSH includes where the behavior usually occurs (e.g., bedroom, bathroom), if tools (e.g., nails, razorblades) are used, and whether DSH occurs alone or in the presence of others (may be virtual presence via online chat groups or social networking sites). All of these details are important when trying to work on altering habits and routines to work toward behavior change.

Examining details about the triggers which precede DSH behavior can help to predict the situations in which future DSH will happen. This allows individuals and care provider to recognize specific opportunities to practice other coping/replacement techniques and can guide attempts to interrupt the chain of thoughts and actions that lead up to DSH. These triggers can be environmental, such as discord in relationship or poor performance in school. Some triggers may be biological factors, such as sleep deprivation, illness, or intoxication. Other triggers are psychological in nature, thought and behavior patterns, affective states, and beliefs. The Suicide Attempt Self-Injury Interview provides a detailed assessment of possible triggers, focusing mainly on environmental triggers, and could be useful as part of a clinical evaluation (Linehan et al., 2006).

In addition, information about the consequences of DSH can help guide treatment. Similar to the assessment of triggers, environmental, biological, and psychological consequences should be examined. An important environmental consequence is the reaction of others to DSH. If the reaction of others reinforces the behavior, it may make sense to try to change that response. Biological consequences include the degree of physical pain experienced, and whether actions are taken to promote wound healing. Important psychological consequences are an individual’s emotional state after DSH, their thoughts regarding the DSH (shame, guilt, pride), and the sequence of behaviors afterward. These details may help to inform treatment approaches, for example, working on self-soothing techniques might be helpful for a patient who experiences relief from anxiety and a calm sensation after DSH, but may be less effective for a patient who feels invigorated and energized after DSH.

Though the intent of DSH in most individuals is not suicide, it is very important for care providers to monitor on an ongoing basis suicidal thinking, plans, and attempts, as many of the psychological characteristics of individuals engaging in DSH put them at a high risk of suicide (Nafisi & Stanley, 2007).


Treatment


Treating self-injuring patients can be challenging, as it is usually a slow process of change, and patients using DSH as a coping mechanism often have difficult personality characteristics. These are often patients that are surrounded by negative judgments, from their families, friends, society, and most importantly, themselves. Even after gaining insight into the reasons for their DSH behaviors, individuals may find it very difficult to change. Some of the methods for maintaining a therapeutic relationship with individuals with DSH behaviors are reviewed here, followed by identification of specific therapies that have demonstrated effectiveness in treating DSH (Gratz, 2007; Klonsky et al., 2003).

One important aspect of care is validation of the patients’ feelings through listening, reflecting, and understanding. Acknowledging that a patient’s emotional pain is real and that you understand DSH provides relief helps a patient feel validated and can facilitate further work on the DSH behavior. This should be validating the effect, not validating DSH as the best means. Also important is for a care provider to firmly support patient self-care and the cessation of DSH behavior. Eliciting the patient’s thoughts about the negative consequences of DSH may be helpful as many people are distressed by the behavior. Being able to present additional concerns if patients are unable to come up with adverse consequences can also help to facilitate contemplation about cessation of DSH. Provider concerns might include that DSH can result in infection, pain, and unintentional severe injury or death. It can lead to social embarrassment and shame because it is not a socially acceptable behavior, and most importantly it does not resolve the patient’s underlying problems. DSH ends up being a cycle of destructive behavior, which the patient relies upon instead of developing healthier coping strategies.

A pitfall to avoid is that overconcern and effusive compassion in response to DSH may inadvertently reinforce the behavior. On the other hand, DSH often elicits strong negative emotions in care providers, causing providers to reprimand patients, ignore or minimize the DSH behavior, or withdraw from the alliance. The most effective approach is to maintain a dispassionate, nonjudgmental demeanor in discussing DSH. It also may be useful when experiencing intense frustration and negative judgments about an individual with DSH to remember that the behavior is functional instead of labeling the individual as manipulative.

In managing the frustration that can occur during the slow course of treatment, it is important to have realistic expectations—that patients with DSH may take longer to progress with therapy than other patient populations, that there will be relapses of the behavior, that you will need to pay close attention to detect small improvements, and that it is common for patients with DSH to resist the introduction of other coping mechanisms either verbally or through noncompliance. Getting support and outside perspective from colleagues to avoid burnout can also be very useful.

Many types of treatment have been utilized for DSH. Please see Table 2 for a summary of the level of evidence for some of the recognized interventions (Karr, Muehlenkamp, & Turner, 2010). Below is a review of pharmacotherapy and cognitive-behavioral and psychodynamic therapy interventions.


Table 2
Summary of published self-injury interventions and respective levels of evidence










































































Intervention

Level of evidence

SORT rating

RCTs

Treatment description

Patients treated in published reports or RCTs (n)

Effect on self-injury

Topiramate

3

C

N/A

200 mg/day

3

Cessation of self-injury

Clozapine

3

C

N/A

300–550 mg/day for 4–12 months

8

Cessation of self-injury

Naltrexone

3

C

N/A

50 mg/day

8

Cessation of self-injury

Dialectical behavior therapy

1

B

3

12-month outpatient program; weekly individual modified cognitive-behavioral therapy; weekly skills training; ongoing skills coaching between sessions

188

Significant reduction of self-injury in 2/3 RCTs compared with TAU group

Manual assisted cognitive-behavioral therapy

3

C

2

2–7 individual cognitive therapy-oriented sessions; 70-page self-help book

512

No effect on self-injury

Transference-focused psychotherapy

2

C

2

12-month outpatient program; weekly individual psychodynamic therapy

23

No effect on self-injury

Mentalization-based therapy

2

C

0

18-month inpatient program; weekly individual psychodynamic therapy; weekly group psychodynamic therapy (3×); weekly individual psychodrama session

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Mar 10, 2017 | Posted by in PSYCHOLOGY | Comments Off on Self-Harm in Adolescents

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