The frequent coexistence of drug use and psychotic symptoms has important implications for how to organize clinical treatment and care irrespective of whether a patient’s drug use precipitated a primary psychotic disorder or a primary psychosis has led to a substance-use disorder. Patients with drug-induced psychosis are at high risk of developing primary psychotic disorder (Caton et al. 2005). Rather than seeing drug-induced psychosis as a phenomenon distinct from primary psychosis, we should consider those who develop psychosis following drug use to be at high risk of developing primary psychosis (Bramness et al. 2012). These patients need to be monitored for signs of primary psychosis to avoid unnecessary delays in treatment, which are associated with poorer outcomes. In the acute phase, pharmacological treatment using both benzodiazepines and antipsychotics should be considered. Antipsychotics may be useful for curbing the acute psychosis and have been found effective in a meta-analysis (Shoptaw et al. 2009), but may also have neuroprotective effects (Curran et al. 2004). The use of benzodiazepines might reduce the need for antipsychotics and may be used to induce sleep, a desired effect in the management of any acute psychotic episode irrespective of its etiology.