A 76-year-old Caucasian male with chronic obstructive pulmonary disease (COPD), type 2 diabetes, peripheral neuropathy, and osteoarthritis presents with complaints of “horrible insomnia.” His wife of 40 years passed away 2 years ago and he is currently living alone. His daughter lives in a nearby town and visits him on a weekly basis. One year prior, his daughter noticed he was having trouble getting around the house to attend to household duties so she hired a home health aide 4 hours a day to assist him. She is concerned because he is depressed and has little energy to participate in pleasurable activities.
CLINICAL HIGHLIGHTS
Screening at-risk patients for suicidal thinking in the primary care setting can prevent suicides.
A number of studies in primary care settings indicate that providers often do not ask depressed patients if they have suicidal thoughts.
The majority of patients who have committed suicide had contact with a primary care provider within the year before their death and 50% of those who took their own life visited a primary care provider within 1 month.
Patients who commit suicide within a month of seeing a primary care provider are predominately older males with chronic physical illnesses who live alone.
Suicide risk assessment involves balancing nonmodifiable and modifiable risk factors for suicide against factors that protect against suicide. The key modifiable risk factor for suicide is depression, particularly depression coupled with severe anxiety.
Screening at-risk patients for suicidal thinking is important in assessing suicide risk and will not cause a patient to start thinking about suicide.
Research has shown that most patients who commit suicide tell family and friends of their wish to die. Therefore, obtaining collateral information from relatives or friends can be an invaluable strategy for detecting patients at high suicide risk.
If clinicians determine that a patient is at significant acute risk of suicide, they should have a “plan of action” in place that ensures the patient is quickly referred to a mental health professional.
Assessment and Management of Suicide Risk
CLINICAL SIGNIFICANCE
One in 10 patients seen in primary care settings meets criteria for major depressive disorder. Depression is particularly common in patients presenting for treatment of a chronic medical condition, with a prevalence of about 30% to 40%. Primary care providers see depressed patients routinely and most are managing these patients with antidepressant pharmacotherapy. Suicidal thinking is a feature of depression and suicide is a potential outcome. Clinicians should therefore be familiar with assessing and managing suicide risk.
Primary care clinicians are better positioned than mental health professionals to identify patients at risk and to intervene to prevent suicide. Clinical contact of depressed patients with primary care providers in the time period preceding a suicide is more common than contact with mental health professions. Three of four suicide victims see a primary care provider in the year before suicide, and nearly half of these patients have contact with their primary care physician in the month before their death, particularly older adults (1). In contrast, only 20% of those who die by suicide see a mental health professional in the month prior to their death (2). Although it is not known whether or not these suicides were preventable, this suggests the clinical encounter immediately before suicide can be an opportunity to identify suicide risk and plan appropriate interventions.
Studies suggest that primary care providers could do a better job at identifying patients at risk for suicide. A recent study examined whether or not suicidal thinking was explored in a group of patients who made an unannounced visit to a primary care clinic complaining of depressive symptoms and requesting an antidepressant. Fewer than half (42%) of patients were asked about suicidal ideations (3). Another study examined whether or not suicidal thinking was explored by primary care physicians in the last visit prior to suicide in a group of patients who committed suicide within a month of contact. Sixty-two percent of these patients were not asked about suicidal thinking, and in half of these cases, the provider had little knowledge of the patient’s life circumstances (4). Suicidal ideation is common in depressed older adults being treated in primary care settings. One in five patients will report suicidal thoughts during a course of treatment for depression, particularly in those with more severe symptoms (5).
SUICIDE RISK ASSESSMENT IN THE PRIMARY CARE SETTING
The striking finding that many of those who commit suicide have seen a primary care provider shortly before their death has led to investigations that attempt to profile the type of patient at risk. One study compared differences between older adults who committed suicide within 30 days of visiting a primary care provider with older primary patients who did not commit suicide. Those who committed suicide had more depressive illness, greater physical illness burden, and functional limitations, and were more likely to be prescribed antidepressants, antianxiety agents, and opiate analgesics (6). A similar study investigated the differences between older men and women who committed suicide shortly after a primary care visit. Male suicides outnumbered female by a ratio of 3:1. Men were more likely to be single or widowed than women. Men were more likely to use hanging as a primary suicide method, whereas women tended to overdose on medications, which suggests care should be exercised in prescribing medications that can be lethal in overdose. In both men and women, the primary complaint involved physical, not psychiatric, symptoms (7). Another study found that older adults were more likely to complain of physical symptoms prior to suicide, whereas younger adults were more likely to seek help for psychiatric symptoms (8).
The assessment of suicide risk is not as simple as asking a patient, “Have you been having suicidal thoughts?” Inquiring about suicidal thinking is important, but is only one piece of performing a suicide risk assessment. The assessment also involves an examination of risk factors for suicide balanced against factors protective against suicide. The more suicide risk factors and fewer protective factors, the greater the risk. There is no specific set of risk factors that have been shown to predict whether or not a patient will commit suicide; because suicide is a very rare event, it is nearly impossible to design and carry out a study with that goal. If primary care providers are aware of key risk and protective factors, however, they can use sound clinical judgment to identify at-risk patients and take steps to reduce the likelihood a suicide will occur.
Nonmodifiable Risk Factors
Certain risk factors are static and cannot be changed with clinical intervention. They include demographic factors (e.g., age, gender, and ethnicity) and certain features of a patient’s clinical history. They are important to recognize because they will indicate which type of patient is at highest risk (Table 14.1).
Demographic Risk Factors Older males are statistically the most likely to die by suicide; elderly men (85 years or older) are at greatest risk with an annual prevalence of 60 suicides per 100,000 (9). Though women attempt suicide three times more often than men, men are four times more likely to die by suicide (10). There are several reasons for the increased risk in men: (1) substance misuse (e.g., alcoholism) is more prevalent among men, (2) men are less willing than women to seek help, (3) men attempt suicide using more lethal methods (e.g., firearms) than women, and (4) females tend to be more socially embedded than men (10). Nevertheless, a significant number of women commit suicide and their risk cannot be discounted. Women with a history of depression and suicide attempts are likely to have poor outcomes postpartum and have increased suicide risk, especially within the first month of delivery (10).
Caucasians and Native Americans are the ethnic groups at highest risk. Their risk of suicide is twice that of African Americans, Hispanics, and Pacific Islanders (10). When examining ethnicity as a risk factor, it is important to also consider age. Suicide rates in all ethnic groups rise sharply from ages 10 to 24, but then plateau into adulthood. Among Caucasian Americans, there is a marked increase in suicide rate in older age, which is not observed in African Americans (9). Thus, African American men commit suicide earlier in life than do Caucasian men (mean ages 34 and 44, respectively) (11). African American females have a remarkably low suicide rate. They are nine times less likely to commit suicide than are Caucasian women. This low suicide rate has been attributed to protective factors of religion and extended kin networks.
Table 14.1 Risk Factors for Suicide
Key nonmodifiable risk factors for suicide
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A past suicide attempt, particularly a serious attempt
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Male gender
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Advanced age (>65 years)
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Caucasian or Native American ethnicity
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Divorced, separated, or widowed
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Unemployment (particularly recent loss of job in those <45 years)
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Alcohol dependence (particularly when facing losses)
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Childhood sexual and physical abuse
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Chronic neurologic illness
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A family history of suicide
Key modifiable risk factors for suicide
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Major depressive episode, especially with prominent anxiety symptoms causing insomnia, psychomotor agitation, decreased concentration, and an inability to experience pleasure
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Alcohol abuse
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Hopelessness
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Suicidal ideation and plan (although some patients intent on suicide may deny these thoughts to health care providers)
Clinical History The most robust nonmodifiable risk factor for suicide is a previous attempt, particularly a past serious attempt (9). A previous attempt dramatically increases the risk of eventual death by suicide. Previous attempters are 38 times more likely to complete suicide than are nonattempters. Serious attempts can be distinguished from less serious attempts by examining the following factors about the previous attempt: (1) it involved a high degree of intent (e.g., when asked, the patient tells you that, prior to the attempt, he or she fully expected to die and was surprised when he or she did not); 2) it involved a degree of planning, including measures to avoid discovery; and (3) it involved lethal or violent methods that resulted in physical injuries (10).
Patients with a chronic psychiatric disorder are at increased risk for committing suicide. The condition that carries the greatest risk is chronic depression in the form of either major depressive disorder or bipolar disorder. Patients with these disorders are 20 times more likely to commit suicide than those without a mental disorder (10). Substance misuse, particularly alcoholism, also increases suicide risk. Those with alcohol dependence are particularly likely to commit suicide when faced with life stressors caused by their misuse: (1) loss or disruption of a close personal relationship (e.g., divorce), (2) job loss, and (3) legal and financial difficulties (10).
Other important nonmodifiable risk factors include being divorced, separated, or widowed; a family history of suicide; a history of childhood abuse (sexual or physical); unemployment (recent job loss is a common precipitant to suicide in males under the age of 45); and having a chronic physical illness, particularly a neurologic illness (epilepsy, multiple sclerosis, Huntington disease, and brain and spinal cord injuries). Certain nonneurologic illnesses associated with increase suicide risk include human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and chronic heart, lung, kidney, and prostate diseases (10). In a recent study, older primary care patients (•65 years) were asked if they were having thoughts they wished they were dead. Those with chronic medical conditions, especially a recent myocardial infarction, were the most likely to report having death wishes (12).
Modifiable Risk Factors
Psychological autopsies (a focused evaluation of the deceased’s life and emotional state before death) conducted on suicide victims have found that 90% meet criteria for one or more psychiatric disorders, predominately a major depressive episode (9). A landmark study involving a large sample of patients with recurrent depression found that the presence of certain symptoms was predictive of suicide within the ensuing year. These symptoms were (1) global insomnia (e.g., disruption of all phases of sleep), (2) psychomotor agitation (e.g., restlessness, pacing), severe anxiety, (4) panic attacks, (5) difficulty concentrating, (6) severe anhedonia (e.g., an inability to experience pleasure), and (7) alcohol abuse (13). In examining these data, experts in suicidology reason that depression is difficult to tolerate and there is a wish to escape through death. The added component of severe anxiety creates an intolerable situation that fuels suicidal thoughts and behaviors (9). Depressed patients who are also anxious are more likely to act on suicidal impulses than those with psychomotor slowing (9).
The strong association between anxiety and suicide has been found in other settings. In a retrospective study of psychiatric inpatients who committed suicide, the vast majority (80%) exhibited signs of anxiety and agitation in the week prior to death (9). Primary care patients with anxiety disorders have an increased risk of suicidal ideations and attempts in both the short and long term. Patients with anxiety symptoms coupled with depression have a significantly greater suicide risk than those with depression alone (14). Other key modifiable risk factors for suicide are strong feelings of hopelessness (15); a wish to destroy the lives of survivors (revenge suicide); extreme feelings of worthlessness, shame, or guilt; and polarized thinking (e.g., rigid thinking in which a patient is unable to consider options other than suicide) (10).
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