Surgical Treatment of Degenerative Spondylolisthesis: Simple Decompression without Fusion
Gianluca Cinotti
Degenerative spondylolisthesis (DS) is a complex condition characterized by the forward slipping of a lumbar vertebra with an intact posterior arch. It can be asymptomatic and thus not require any treatment, or it can cause a wide spectrum of symptoms including low back pain, radicular pain, or both.
Surgical treatment of degenerative spondylolisthesis includes simple decompression, simple fusion, or decompression plus fusion. The latter, in recent years, has been considered the treatment of choice of DS since several studies have shown that higher percentages of satisfactory results are reported when fusion is added to decompression (1,2,3,4,5,6). Although it is certainly true that, overall, fusion increases the percentages of satisfactory results in patients with this condition, it is the author’s opinion that the surgical treatment of DS should vary according to the clinical and radiologic findings and that simple decompression should be considered a possible option in selected patients with DS. The rationale for this assumption is based on several findings: (a) early studies showed that high percentages of patients submitted to simple decompression reported satisfactory results (7,8); (b) after decompression and fusion, high percentages of satisfactory results were also reported by patients with pseudarthrosis (4,5,6,7,8,9) probably meaning that decompression, rather than fusion, was the necessary treatment in these patients; (c) it is widely reported that fusion increases the perioperative and postoperative morbidity, operative time, need for blood transfusion, and risks for degenerative changes at adjacent levels (10,11). Therefore, if there are patients with DS for whom simple decompression may be successful, to add fusion should be considered an overtreatment. Last, and possibly most important, a manifest spinal instability, which requires fusion, is not always present in DS.
SPINAL INSTABILITY IN DS
Spinal instability is defined as the loss of the ability of the spine to maintain its pattern of displacement under loads with subsequent nerve compression, deformity, or pain. According to this, DS should be considered a condition of spinal instability. However, the degree of instability present in DS and whether such an instability is about the same in any patient with this condition are still open questions. The uncertainty on these issues is increased by the fact that the criteria to be used to detect an instability in the degenerated spine are still controversial.
Historically, radiologic and clinical criteria have been used to diagnose spinal instability. Radiologic criteria include flexion-extension radiographs and, more recently, computed tomography (CT) and magnetic resonance imaging (MRI) under axial loading. The latter may provide information on the degree of vertebral slipping occurring during standing, but the clinical relevance of the results needs further clarification.
The results of flexion-extension radiographs in DS patients have been reported using defined parameters to diagnose abnormal vertebral motion (12). The olisthetic vertebra was found to show abnormal angular motion in 48% of cases, abnormal sagittal translation in 48%, and both in 37%. However, it was also found that about one third of patients with DS (31%) showed vertebral motion within normal values.
Clinical symptoms related to spinal instability in DS include postural and standing low back pain. Radicular pain may also be present on standing or walking although, in DS patients, this symptom is more likely to be related to spinal stenosis than to spinal instability. The severity of low back pain may vary remarkably in each patient. It may be the predominant symptom, it can be equal to radicular pain, or it can be mild or even absent. It is extremely important to investigate carefully the presence and severity of low back pain, particularly in patients in whom flexion-extension radiographs do not show any evident hypermobility of the olisthetic vertebra. In these cases, in fact, the presence of low back pain may be the only finding suggesting that an occult spinal instability is present.
In general, the majority of patients with DS complain of low back pain with or without radicular pain. However, a minority of patients (about 20% to 30%) complain of radicular pain with no, or mild, low back pain.
In conclusion, even considering the known limitations in detecting spinal instability, there are clinical and radiologic findings suggesting that about one third of DS patients do not show evidences of manifest spinal instability.
SPINAL INSTABILITY IN DS AFTER DECOMPRESSION
Many surgeons advocate fusion for patients with DS, even if low back pain is not present preoperatively, because surgical decompression will increase spinal instability to such an extent that low back pain will be present postoperatively. There are no studies, however, supporting this statement.