Intraventricular neurocytomas (IVNs) are rare tumors of neuronal differentiation, accounting for 0.1% to 0.5% of all primary brain tumors. Complete surgical resection is highly recommended, but at least one-third to one-half are subtotally resected. Stereotactic radiosurgery (SRS) and conventional radiotherapy have been used for management of residual and recurrent tumors, but the optimal treatment following subtotal surgical resection is less clear. Although there are trends toward higher local tumor control and survival rates with lower complications among IVNs treated with SRS, higher quality data are required to confirm these findings.
Key points
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Adjuvant stereotactic radiosurgery (SRS) or conventional radiotherapy (cRT) for neurocytoma leads to long-term local control rates in excess of 85%.
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The relative risks of local recurrence and all-cause mortality after SRS for neurocytoma are slightly less than with cRT, but not statistically significant.
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Neurocytoma recurrence after radiotherapy is significantly associated with histologic atypia, but not extent of resection or radiation modality.
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Severe complications are slightly less common in neurocytoma patients treated with SRS, relative to cRT.
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Distant tumor recurrence is slightly lower in neurocytoma patients treated with cRT, relative to SRS.
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