Thrombocytopenia




(1)
Departments of Internal Medicine & Psychiatry, Yale University School of Medicine, New Haven, CT, USA

 



A platelet count of <150,000 cells/μL is considered thrombocytopenia. However, 2.5% of the population has counts less than this cutoff.



















Thrombocytopenia

Platelet count (cells/μL)

Mild

100,000–150,000

Moderate

50,000–100,000

Severe

<50,000


Pathology


Thrombocytopenia is caused by deficient production in the bone marrow, immune-mediated peripheral destruction, or increased sequestration in the spleen.


Etiology


Causes other than psychotropic agents are listed as follows.



Common conditions associated with thrombocytopenia

















Nonpsychotropic drugs (antibiotics, cardiac medications, nonsteroidal anti-inflammatory agents)

Chronic infections—HIV, Hepatitis C

Chronic liver disease

Chronic alcohol use

Nutritional deficiencies (Vit B12, folate)

Idiopathic thrombocytopenic purpura (ITP)


Psychotropic Medications and Thrombocytopenia


Drug-induced thrombocytopenia is usually mediated by immune mechanisms, namely, platelet destruction by platelet reactive antibodies. Bone marrow suppression is a less common cause of isolated drug-induced thrombocytopenia.

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Jun 25, 2017 | Posted by in PSYCHOLOGY | Comments Off on Thrombocytopenia

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