Translational stroke studies, including animal modeling, are greatly needed to safely integrate basic preclinical scientific principles ahead of clinical application [32–36]. Thus, this modification of the “wet-dry” brain edema method permits brain volume determination using valuable post hoc dried brain tissue. Perhaps the greatest strength of this approach is the acquisition of additional valuable data without greatly added expense to neuroscience laboratories. Nonetheless, the application of these volumetric measurements needs validation in other studies, across models and species. In the meantime, this breakthrough technique remains a hammer without a nail but we hope not for much longer.