Mutant and Transgenic Tools in Modeling Schizophrenia

PubMedCrossRef




6.

Chen J, Lipska BK, Weinberger DR (2006) Genetic mouse models of schizophrenia: from hypothesis-based to susceptibility gene-based models. Biol Psychiatry 59:1180-1188PubMedCrossRef


7.

O’Tuathaigh CMP, Babovic D, O’Meara G et al (2007) Susceptibility genes for schizophrenia: phenotypic characterisation of mutant models. Neurosci Biobehav Rev 31:60-78PubMedCrossRef


8.

Desbonnet L, Waddington JL, O’Tuathaigh CM (2009) Mutant models for genes associated with schizophrenia. Biochem Soc Trans 37:308-312PubMedCrossRef


9.

Desbonnet L, Waddington JL, O’Tuathaigh CM (2009) Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes? Brain Behav Res, (in press)


10.

Tandon R, Nasrallah HA, Keshavan MS (2009) Schizophrenia, “just the facts”: Part 4: Clinical features and conceptualization. Schizophr Res, (in press)


11.

Bocti C, Black DN, Waddington JL (2004) Dyskinesia in patients with schizophrenia never treated with antipsychotics: conceptual and pathophysiological implications. In: Bedard MA (ed) Mental and behavioural dysfunction in movement disorders. Humana Press, Totawa, NJ, pp 489-498


12.

Tomiyama K, O’Tuathaigh CM, O’Sullivan GJ et al (2009) Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 “knockout” mice. Prog Neuropsychopharmacol Biol Psychiatry 33:330-333PubMedCrossRef


13.

Whitty PF, Owoeye O, Waddington JL (2009) Neurological signs and involuntary movements in schizophrenia: intrinsic to and informative on systems pathobiology. Schizophr Bull 35:415-424PubMedCrossRef


14.

Waddington JL, Morgan MG (2001) Pathobiology of schizophrenia. In: Lieberman JA, Murray RM (eds) Comprehensive care of schizophrenia. Martin Dunitz, London, pp 28-35


15.

Gogos JA (2007) Schizophrenia susceptibility genes: in search of a molecular logic and novel drug targets for a devastating disorder. Int Rev Neurobiol 78:397-422PubMedCrossRef


16.

Allen NC, Bagade S, McQueen MB et al (2008) Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40:827-834PubMedCrossRef


17.

Shi J, Gershon ES, Liu C (2008) Genetic associations with schizophrenia: Meta-analyses of 12 candidate genes. Schizophr Res 104:96-107PubMedCrossRef


18.

Gavériaux-Ruff C, Kieffer BL (2007) Condi­tional gene targeting in the mouse nervous system: Insights into brain function and diseases. Pharmacol Ther 113:619-634PubMedCrossRef


19.

O’Neal KR, Agah R (2007) Conditional targeting: inducible deletion by Cre recombinase. Methods Mol Biol 366:309-320PubMedCrossRef


20.

Crawley JN (2008) Behavioral phenotyping strategies for mutant mice. Neuron 57:809-818PubMedCrossRef


21.

Low NC, Hardy J (2007) What is a schizophrenic mouse? Neuron 54:348-349PubMedCrossRef


22.

Tecott LH, Nestler EJ (2004) Neurobehavioral assessment in the information age. Nat Neurosci 7:462-466PubMedCrossRef


23.

Waddington JL, O’Tuathaigh C, O’Sullivan G et al (2005) Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10   years at the psychopharmacology-molecular biology interface. Psychopharmacology 181:611-638PubMedCrossRef


24.

O’Tuathaigh CM, O’Sullivan GJ, Kinsella A et al (2006) Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice. NeuroReport 17:79-83PubMedCrossRef


25.

Babovic D, O’Tuathaigh CM, O’Sullivan GJ et al (2007) Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice. Behav Brain Res 183:236-239PubMedCrossRef


26.

Moy SS, Nadler JJ, Perez A et al (2004) Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. Genes Brain Behav 3:287-302PubMedCrossRef


27.

O’Tuathaigh CM, Babovic D, O’Sullivan GJ et al (2007) Phenotypic characterization of spatial cognition and social behavior in mice with ‘knockout’ of the schizophrenia risk gene neuregulin 1. Neuroscience 147:18-27PubMedCrossRef


28.

Babovic D, O’Tuathaigh CM, O’Connor AM et al (2008) Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase. Neuroscience 155:1021-1029PubMedCrossRef


29.

Guillin O, Abi-Dargham A, Laruelle M (2007) Neurobiology of dopamine in schizophrenia. Int Rev Neurobiol 78:1-39PubMedCrossRef


30.

Goldman-Rakic PS (1998) The cortical dopamine system: role in memory and cognition. Adv Pharmacol 42:707-711PubMedCrossRef


31.

Mattay VS, Goldberg TE, Fera F et al (2003) Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci USA 100:6186-6191PubMedCrossRef


32.

Vijayraghavan S, Wang M, Birnbaum SG et al (2007) Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nat Neurosci 10:376-384PubMedCrossRef


33.

Coyle JT (2006) Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol 26:365-384PubMedCrossRef


34.

Stone JM, Morrison PD, Pilowsky LS (2007) Glutamate and dopamine dysregulation in schizophrenia-a synthesis and selective review. J Psychopharmacol 21:440-452PubMedCrossRef


35.

Pilowsky LS, Bressan RA, Stone JM et al (2006) First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients. Mol Psychiatry 11:118-119PubMedCrossRef


36.

Castner SA, Williams GV (2007) Tuning the engine of cognition: a focus on NMDA/D1 receptor interactions in prefrontal cortex. Brain Cogn 63:94-122PubMedCrossRef


37.

Bertram L (2008) Genetic research in schizophrenia: new tools and future perspectives. Schizophr Bull 34:806-812PubMedCrossRef


38.

Chubb JE, Bradshaw NJ, Soares DC et al (2008) The DISC locus in psychiatric illness. Mol Psychiatry 13:36-64PubMedCrossRef


39.

Muir WJ, Pickard BS, Blackwood DH (2008) Disrupted-in-schizophrenia-1. Curr Psychiatry Rep 10:140-147PubMedCrossRef


40.

Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636-645PubMedCrossRef


41.

Braff DL, Freedman R, Schork NJ et al (2007) Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull 33:21-32PubMedCrossRef


42.

Kellendonk C, Simpson EH, Polan HJ et al (2006) Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron 49:603-615PubMedCrossRef


43.

Drew MR, Simpson EH, Kellendonk C et al (2007) Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing. J Neurosci 27:7731-7739PubMedCrossRef


44.

Bach ME, Simpson EH, Kahn L et al (2008) Transient and selective overexpression of D2 receptors in the striatum causes persistent deficits in conditional associative learning. Proc Natl Acad Sci USA 105:16027-16032PubMedCrossRef


45.

Waddington JL, Clifford JJ, McNamara FN et al (2001) The psychopharmacology-molecular biology interface: exploring the behavioural roles of dopamine receptor subtypes using targeted gene deletion (‘knockout’). Prog Neuropsychopharmacol Biol Psychiatry 25:925-964PubMedCrossRef


46.

O’Sullivan GJ, O’Tuathaigh CM, Tomiyama K, et al. Dopamine receptors and behaviour: From psychopharmacology to mutant models. In: Neve KA, ed. The dopamine receptors. New Jersey: Humana Press, 2009 (in press).


47.

Tomiyama K, McNamara FN, Clifford JJ et al (2002) Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor ‘knockout’ mice. Neuropharmacology 42:644-652PubMedCrossRef


48.

Tomiyama K, McNamara FN, Clifford JJ et al (2004) Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor ‘knockout’ mice. Synapse 51:71-81PubMedCrossRef


49.

Tomiyama K, Makihara Y, Yamamoto H et al (2006) Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction ‘knockout’. Eur Neuropsychopharmacol 16:437-445PubMedCrossRef


50.

Gainetdinov RR, Jones SR, Fumagalli F et al (1998) Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis. Brain Res Rev 26:148-153PubMedCrossRef


51.

Hoffman BJ, Hansson SR, Mezey E et al (1998) Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system. Front Neuroendocrinol 19:187-231PubMedCrossRef


52.

Gainetdinov RR, Jones SR, Caron MG (1999) Functional hyperdopaminergia in dopamine transporter knock-out mice. Biol Psychiatry 46:303-311PubMedCrossRef

Apr 2, 2017 | Posted by in NEUROSURGERY | Comments Off on Mutant and Transgenic Tools in Modeling Schizophrenia

Full access? Get Clinical Tree

Get Clinical Tree app for offline access