Abstract
Spontaneous ICH remains a significant cause of morbidity and mortality throughout the world. The aim of this chapter is to provide the etiology, presentation, and treatment of this disease.
3 Cerebrovascular Emergency: Spontaneous Intracerebral Hemorrhage (ICH)
3.1 Epidemiology
About 40 to 80% of ICH patients die within the first 30 days and half of all deaths occur within the first 48 hours. 1
Incidence is 12 to 31 per 100,000 people and increases with age, doubling every 10 years after age 35. 2 , 3
Occurs most in Asians followed by African Americans followed by Caucasians. 4
Risk factors include hypertension, age, alcohol intake, very low low-density lipoprotein (LDL) and cholesterol levels. 5
3.2 Etiologies/Differential Diagnosis
Hypertension is the most common cause
Cerebral amyloid angiopathy (in elderly, age >60 years)
Vascular malformations
Trauma
Coagulopathy
Aneurysm
Hemorrhagic transformation of infarction
Tumors
Neoplasm
Venous sinus thrombosis
Drugs—cocaine and appetite suppressants
3.3 Common Clinical Presentations
Headache, seizures, vomiting, worsening Glasgow coma score (GCS)
Neurologic deterioration can be gradual or rapid, depending on location and size of hemorrhage
Hypertensive hemorrhage tends to occur in the following locations (Fig. 3‑1)
Basal ganglia/thalamus > lobar > cerebellum > pons
Localizing symptoms
Basal ganglia/thalamus: hemisensory loss, hemiplegia, aphasia, homonymous hemianopsia, eye deviation toward the lesion but in rare cases have eye deviation away from lesion (“wrong way eyes”), upgaze palsy
Lobar seizures, homonymous hemianopsia, plegia or paresis more commonly in the leg than arm
Cerebellum ataxia, nystagmus, intractable vomiting, hydrocephalus
Pons pinpoint pupils, quadraparesis, coma, locked-in syndrome
Amyloid bleed is mostly lobar
Vascular malformations (cavernous malformation, arteriovenous malformation [AVM], dural arteriovenous fistula [dAVF]) can occur anywhere

3.4 Neuroimaging
Computed tomography (CT) of the head without contrast as soon as possible and then 24 hours after admission. If the patient is on anticoagulation more frequent imaging may be warranted (at 12 and 24 hours) while reversal of coagulopathy is in process.
CT angiography (CTA) of the head and neck is usually not indicated. However, in the following circumstances, a CTA may be helpful to rule out
Subarachnoid hemorrhage
AVM/Cavernous malformation
Hemorrhagic brain tumor
Fluid levels seen on CT scan indicate a coagulopathy
Volume assessment: ABC/2 estimate
Can use ABC/3 for hemorrhages secondary to warfarin
Magnetic resonance imaging (MRI) of brain with and without contrast to evaluate for underlying mass if no etiology is found (4–6 weeks post hemorrhage)
Appearance of hemorrhages on MRI (see Table 3‑1)

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