Acute Quadriplegic Myopathy
Also known as “critical illness myopathy.”
Corticosteroids, nondepolarizing neuromuscular blocking agents, or both considered the prime inciting factors. Condition may appear in critically ill patients without exposure to either agent. Particularly vulnerable: patients being treated for status asthmaticus, organ transplantation, severe trauma, all likely to have received high doses of steroids in addition to blocking agents.
Clinical features: severe quadriplegia and muscle wasting 4 to 105 days after starting intensive care. Limb weakness usually diffuse, plus respiratory; tendon reflexes often lost. Diagnosis suspected when weaning patient from mechanical ventilation proves difficult (respiratory muscle weakness). Improvement: generally occurs over several months, but may be more protracted.Stay updated, free articles. Join our Telegram channel
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