Presentation in youth
Young people, like adults, may be afflicted with any of the anxiety and mood disorders outlined in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; APA 1994) as well as with separation anxiety disorder and selective mutism, which are placed in the section “Disorders Usually First Diagnosed in Infancy, Childhood, or Adolescence.” Males and females are equally likely to have mood disorders in pre-adolescence, but by adolescence females are twice as likely to experience depression (Avenevoli, Knight, Kessler, and Merikangas 2008). With respect to anxiety disorders, girls are more likely to have an anxiety disorder than boys, although the differences are not large (Costello, Egger, and Angold 2005).
The presentation of mood and anxiety disorders may be somewhat different in youth from what it is in adults. For instance, for youth with mood disorders, DSM-IV adjusts time and symptom requirements. For dysthymia, symptoms need only be present for one year rather than two, while for depression youth may show irritability rather than depressed mood and failure to make expected weight gain rather than weight loss during depressive episodes. It has also been found that depressed children are more likely to present with somatic complaints than adolescents and adults, that girls tend to display more hypersomnia and reduced appetite during adolescence, and that suicide risk peaks during middle adolescence for girls and during late adolescence for boys (Avenevoli et al. 2008). Finally, for preschool children, anhedonia may manifest itself as a difficulty to enjoy play activities, and preoccupation with negative thoughts may manifest themselves as preoccupation with play themes (Luby 2010).
DSM-IV also suggests differences in the presentation of anxiety disorders in youth by comparison with adults. In specific phobia (SP) crying, tantrums, freezing, or clinging may be evident; the child may not realize that his or her fear is excessive or unreasonable; and the duration of symptoms must be at least six months. The “other” category of phobias may include avoidance of loud sounds or of costumed characters. For social phobia (SoP) crying, tantrums, freezing, or shrinking away from social situations with unfamiliar people may occur; there must be evidence that the child can develop and maintain social relationships with familiar others; the anxiety must be triggered by same-age peers as well as by adults; the child may not realize that his or her anxiety is unreasonable or excessive; and the symptoms must be present for at least 6 months. In obsessive compulsive disorder (OCD) the child may not recognize that the obsessions and compulsions are excessive or unreasonable, while in generalized anxiety disorder (GAD) only one of the six core symptoms must be present for diagnosis. For post-traumatic stress disorder (PTSD) the response may be expressed through disorganized or agitated behavior, and the re-experiencing of the event may be evidenced by repetitive play involving the trauma theme, frightening dreams where the child fails to recall or recognize the content, or episodes of re-enactment of the trauma. Thus it is evident that there are differences between the presentation of mood and anxiety disorders in youth and the presentation of the same disorders in adults.
Comorbidity
When youth show symptoms of anxiety or depression, they frequently show symptoms of other disorders as well. for anxiety disorders, comorbidity with other anxiety disorders is most common (Ollendick, Jarrett, Grills-Taquechel, Hovey, and Wolff 2008), and our own research suggests that 89 percent of the youth involved in treatment for anxiety disorders hold more than one clinical-level anxiety diagnosis. Comorbid mood disorders are also common: 10 to 15 percent of anxious youth display comorbid depression (Garber and Weersing 2010). When comorbid depression is present in anxious youth, the young person tends to be somewhat older, the anxiety is more severe, and family dysfunction is higher (O’Neil, Podell, Benjamin, and Kendall 2010). Finally, externalizing disorders such as attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD) and conduct disorder (CD) are commonly comorbid with youth anxiety (Ollendick et al. 2008). Angold, Costello, and Erkanli (1999) suggest that around 10 percent of youth with an anxiety disorder have comorbid CD or ODD and that anxiety and ADHD co-occur at a rate three times higher than what would be predicted by chance.
Comorbidity is also very common in youth with mood disorders. Comorbidity with anxiety disorders is most commonplace, with 25–75 percent of depressed youth also being diagnosed with an anxiety disorder (Angold et al. 1999, Garber and Weersing 2010). Rates of comorbid externalizing disorders seem to vary considerably across studies: ranges between 0 and 79 percent are found for CD and ODD, and rates of 0 and 5 percent are found for ADHD (Angold et al. 1999). Of particular concern is the high rate of suicidal ideation and attempts evidenced in depressed teenagers (Kovacs, Goldston, and Gatsonis 1993). Indeed, when youth with depression have comorbid disorders, the onset of depression tends to be earlier and suicidal behavior tends to be more common (Lewinsohn, Rohde, and Seeley 1998). Furthermore, when depressed youth also demonstrate suicidality, both depression severity and impairment are greater (Barbe, Bridge, Birmaher, Kolko, and Brent 2004).
From the above discussion it would seem that comorbidity is associated with greater severity and impairment, or at least with more complex diagnostic profiles. But how does this impact on treatment? For anxiety disorders, the news is relatively good. The results of two large reviews suggest that, for the vast majority of studies, comorbidity is not predictive of poorer treatment outcome for youth with anxiety disorders (Nilsen, Eisemann, and Kvernmo 2012; Ollendick et al. 2008). Furthermore, it has been found that focusing treatment on the primary anxiety disorder also results in the reduction of comorbid anxiety disorders and of other comorbid disorders such as depression, ADHD, and ODD (see, e.g., Kendall, Brady, and Verduin 2001). It may therefore not be necessary (or efficient) for clinicians to attempt to incorporate treatment components for comorbid conditions; they should rather focus on treating the primary anxiety disorder and determine later whether additional treatment is required.
For youth suffering from mood disorders, the presence of comorbidity seems less clear in terms of its effect on treatment outcome. Some reviews and large-scale studies have concluded that comorbidity, and particularly comorbidity with anxiety, is associated with poorer outcome (e.g., Emslie, Kennard, and Mayes 2011; Ollendick et al. 2008), while others have found little effect (Nilsen et al. 2012). What is clear is that suicidality predicts poorer treatment outcome and is associated with dropout, and that treating depression does not necessarily lead to a reduction in suicidality or vice-versa (Barbe et al. 2004). Furthermore, it has been found that focusing on adolescent depression has the effect of also reducing anxiety symptoms, but not externalizing problems (e.g., Weisz, McCarty, and Valeri 2006). Thus it may not be necessary for clinicians to target comorbid anxiety in depression treatment (at least not initially), but treatment should include strategies aimed at reducing comorbid externalizing problems and should allow for specific considerations related to the importance of suicidality.