Substance type
Examples
Arousal and/or erection
Orgasmic function
Antihypertensives
α- and β-blockers, sympathetic inhibitors
x
x
Antidepressants
SSRIs, MAOIs, tricyclics
x
x
Antipsychotics
Phenothiazines, thioxanthenes
x
x
Antiepileptics
Gabapentin, topiramate, etc.
x
x
Anxiolytics/tranquilizers
Benzodiazepines
x
Hypnotics/sedatives
Barbiturates, alchohol
x
x
Muscle relaxants
GABA β receptor agonists
–
x
Cancer treatments
GRH agonists
x
–
Immunosuppressive
Sirolimus, everolimus
x
–
Antiandrogens
Finasteride, cyproterone acetate, etc.
x
x
Steroids
Prednisone
x
?
Analgesics
Opiods, methadone
x
Other
Antihistamines, pseudoephedrine, recreational
x
?
As mentioned previously, most ejaculatory problems increase with aging, not only those associated with longer latencies. This increase may be due not only to an overall decrease in health and stamina, but also to increased prevalence of specific diseases. For example, the severity and frequency of lower urinary tract symptoms (LUTS) increases with age, yet this condition also exerts effects on ejaculatory function beyond (i.e., independent of) those of just aging [25, 26]. Diminished penile sensitivity associated with aging, diabetes, and various chronic diseases may also reduce the efficacy of penile stimulation, and when coupled with diminished stimulation from an aging partner (e.g., loss of vaginal elasticity that occurs with aging), the amount and intensity of genital stimulation may be insufficient to reach ejaculation [10, 27]. Nevertheless, reduced penile sensitivity is unlikely to be a primary cause for DE; more likely, ejaculatory latency is influenced more by central (cognitive-affective-arousal) processes than peripheral hardwiring of spinal reflexes [20].
More difficult to assess is whether the man may have lost physical stamina or endurance over the years as the result of general health issues and/or aging. Lack of stamina may result in physical and mental fatigue, distraction, less vigorous thrusting, and thus sooner abandonment of the effort. For comparison, about 125–150 calories are burned during 30 min of sexual intercourse for 155 lb man, with a typical heartrate reaching 110–120 bpm during orgasm [28]1. Caloric use during sex is equivalent to about 30 min of leisure cycling, kayaking, low-medium impact aerobics, or brisk pace walking, although this use increases by about 15% for a man weighing 180 lbs, and 30% for a man weighing 200 lbs. Heart rate during moderate cycling may typically range from 95–120 bpm. Thus, men lacking sufficient stamina may, for example, need to devise creative ways with their partners to achieve levels of arousal sufficient for orgasm that preclude vigorous physical exertion.
From the clinician’s perspective, pathophysiological and physiological factors have three important implications. First, any man having recently (or over a period of time) acquired DE should be referred for a medical exam that might include attention to the pelvic area, recent medications, or other disease states. Second, if no obvious pathophysiology is identified, then psychological and relationship factors warrant careful exploration. And third, the clinician might use the opportunity to educate the patient and his partner regarding possible inherent (and naturally occurring) biological differences in the hardwiring of ejaculatory response and latencies, thereby removing some of the burden of guilt and responsibility often associated with this sexual dysfunction.
Cultural Factors
Culturally derived expectations may contribute to DE in some men. A relationship between religious orthodoxy and DE was first proposed in Masters and Johnson’s Human Sexual Inadequacy [3] where the authors suggested that certain beliefs may inhibit normal ejaculatory response or limit the sexual experience necessary for developing control over ejaculation. Consistent with this notion, Perelman [8] reported that in a clinical sample of 75 DE men, about 35% scored high on religious orthodoxy. Some such men tended to have limited sexual knowledge and, perhaps due to religious strictures, had masturbated minimally or not at all. Others, similar to their less religious counterparts, had masturbated for years, but due to their particular religious upbringing or restrictive household attitudes toward sex, they had experienced guilt and anxiety about this sexual outlet, which in turn resulted in DE [8]. As religious taboos and health concerns about masturbation have waned in Western cultures over the past half century, the effects of these specific cultural factors have undoubtedly become less significant among younger men. Despite the lack of supporting data, however, one might imagine that men from cultures or developmental environments that forbid masturbation or reinforce negative attitudes about sexuality in general, and “spilling seed” in particular, might well experience problems with DE.
Psychological and Relationship Factors
Psychological and relationship factors are often involved in long or increasing ejaculatory latencies in some men. In such men, the problem may evolve gradually over a period of time—sometimes years—but not reach levels of concern until a particular need is unfulfilled (e.g., to start a family) or unless the sexual activity involves the partner.
Psychological factors may include specific emotions and cognitions tied to the evaluative/performance aspects of sex with a partner [29]. Self and perceived partner expectations can lead to “sexual performance anxiety ” which may then contribute to DE. Such anxiety typically stems from the individual’s lack of confidence to perform adequately, to appear and feel attractive (body image), to satisfy his partner sexually, to experience an overall sense of self-efficacy—in some respects to measure up to the “competition” [30, 31]. The impact of this anxiety on men’s sexual response varies depending on the individual and the situation. But in some men, it may interfere with the ability to respond adequately and it may, as a result, generate a number of maladaptive responses (e.g., setting unrealistic expectations). With respect to DE, anxiety surrounding the difficulty of ejaculating may draw the man’s attention away from erotic cues that normally serve to enhance arousal. Accordingly, Apfelbaum [32] has emphasized the need to remove the “demand” (and thus anxiety-producing) characteristics of the situation, noting that men with DE may be overly conscientious about pleasing their partner. This “ejaculatory performance” anxiety interferes with the erotic sensations of genital stimulation, resulting in levels of sexual excitement and arousal that are insufficient for climax although more than adequate to maintain an erection.
Relationship factors may be associated with current interpersonal dynamics or with longer term relationship developmental changes. In some instances, sex with the partner may become insufficiently arousing for the man to reach ejaculation, a situation that may involve any number of factors operating individually or together. For example, some men may have a strong “autosexual” orientation that involves an idiosyncratic and vigorous masturbation style—carried out with high frequency—which does not “match” vaginal stimulation [11]. As a result, the stimulation generated from vaginal thrusting may no longer be sufficiently arousing/intense for the man to reach ejaculation or, in other words, the vagina is unable to compete with the habitual strokes and tighter grip of the moving hand. In other instances, disparity between the reality of sex with the partner and the man’s sexual fantasy (whether or not conventional) used during masturbation is another potential cause of DE [11]. At a time when explicit sexual/erotic materials can be accessed easily, in complete privacy (sometimes secrecy), and at little or no cost, such disparity between expected/fantasized sex and actual sex may be increasing in frequency. These disparities may involve a number of different factors, such as the partner’s attractiveness and body type (relative to that of, say, a porn star), homosexual or heterosexual attraction, and the specific sex activity performed (e.g., oral vs. anal vs. vaginal), with each having the potential to diminish arousal cues during partnered sex. In most instances, these men fail to communicate their preferences to their partners because of shame, embarrassment, or guilt. Yet such behavioral and cognitive patterns may well predispose men to experience problems reaching ejaculation—these men are simply not sufficiently aroused during coitus (as they might be during masturbation) to achieve orgasm.
The above issues suggest then that DE men may lack sufficient levels of physical and/or psychosexual arousal during coitus: their arousal response to their partner cannot match their response to self-stimulation, self-generated fantasy, and/or pornography. Support for this idea has been provided by several observations. First, psychophysiological investigation of men with DE has demonstrated that although they attain erectile responses comparable to or better than sexually functional controls during visual and penile psychosexual stimulation, they report far lower levels of psychosexual arousal [13, 33]. Apfelbaum [32] has suggested that during partnered sex the couple interprets the (DE) man’s strong erectile response as erroneous evidence that he is ready for sex, highly aroused, and capable of achieving orgasm. Second, inadequate arousal may also be responsible for increased anecdotal clinical reports of DE for men using oral medications such as PDE-5 inhibitors (e.g., Viagra) for the treatment for ED [34, 35]. While most men using PDE-5 inhibitors experience restored erections and coitus with ejaculation, others experience erection in the absence of comparable psychoemotional arousal, confusing their erect state as an indication of sexual arousal when it primarily indicated vasocongestive success [36].
As the clinician might surmise, discussions about masturbation style and frequency, attractiveness of the partner, sexual fantasies (either conventional or unconventional), and the use of pornography are extremely sensitive topics and most men would feel shame and embarrassment discussing such topics openly with the clinician (or with their partner). Such topics could only be broached after an atmosphere of openness is reinforced and a sense of trust between clinician and patient has been well established (see Sect. “Steps in the evaluation process of DE”).
From the health care provider’s perspective, an understanding of the man’s personal experience and interpretation of his impairment is important—how it makes him feel, how it affects his thoughts and feelings, how it affects his relationship with his partner, and so on. Furthermore, evaluating both the man and his partner to determine the impact of DE on the couple’s relationship may be helpful. Since effective treatment of DE usually requires the cooperation of the partner, including the partner in the evaluation process can help establish the precedent that remediation of DE will require both partners working as a team. In addition, engaging the man and his partner early in the process can help address both sexual and nonsexual relationship issues—often intertwined—which may result in more positive outcomes regarding overall sexual satisfaction than merely focusing on narrow response sets such as ejaculatory latency.
Defining and Diagnostic Criteria
Defining Delayed Ejaculation
Delayed ejaculation is listed among the sexual dysfunctions in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5 : 302.74) [37]. It is characterized as a marked delay or infrequency of ejaculation occurring in about 75–100% of partnered sexual activity, accompanied by a desire not to delay the ejaculation—indicating that the delay is neither intentional nor wanted. In addition, the DSM-5 definition assumes that the condition is accompanied by clinically significant distress and that it has persisted for at least 6 months. The International Classification of Diseases ((ICD-10 Version 2016: www.who.int/classifications/icd/en/) [38], the standard diagnostic tool used to monitor the incidence and prevalence of diseases and other health problems, also includes a code for delayed ejaculation under the nomenclatures of “inhibited orgasm” and “psychogenic anorgasmy ;” (F52.3, Orgasmic Dysfunction: Inhibited Orgasm [male][female]), the latter suggesting a condition of orgasmic absence distinguished by its psychological origin. Neither the DSM-5 nor ICD-10 classification is fully inclusive, comprehensive, or clear in meaning. For example, DSM-5 neither temporally defines “delay” nor specifies situations of inadequate arousal or severe relationship distress in the classification. ICD-10, on the other hand, does not elaborate upon its coding categories to differentiate orgasm from ejaculation, or inhibited orgasm from psychogenic anorgasmy; and it too provides no temporal parameters for “delay,” stating only that orgasm “does not occur or is markedly delayed.” To its credit, DSM-5 includes relevant qualifiers such as “acquired” or “lifelong” (see Sect. “Lifelong vs. acquired DE”), and “generalized” or “situational,” along with designation of “mild, moderate, or severe.” In addition, DSM-5 notes the importance of considering five other factors: (1) partner, (2) relationship, (3) individual vulnerability (e.g., history of abuse), psychiatric comorbidity (e.g., depression), and stressors, (4) cultural/religious influences, and (5) medical factors. The relevance of these risk/qualifying factors were discussed in detail in Sect. “Etiology, Physiology, and Pathophysiology,” of this chapter (see Table 16-2).
Table 16-2.
DSM-5 Diagnostic Criteria for Delayed Ejaculation 302.74 (F52.32)
A. Either of the following symptoms must be experienced on almost all or all occasions (approximately 75–100%) of partnered sexual activity (in identified situational contexts or, if generalized, in all contexts), and without the individual desiring delay: |
1. Marked delay in ejaculation |
2. Marked infrequency or absence of ejaculation |
B. The symptoms in Criterion A have persisted for a minimum duration of approximately 6 months |
C. The symptoms in Criterion A cause clinically significant distress in the individual |
D. The sexual dysfunction is not better explained by a nonsexual mental disorder or as a consequence of severe relationship distress or other significant stressors and is not attributable to the effects of a substance/medication or another medical condition |
Specify whether: |
Lifelong: The disturbance has been present since the individual became sexually active |
Acquired: The disturbance began after a period of relatively normal sexual function |
Specify whether: |
Generalized: Not limited to certain types of stimulation, situations, or partners |
Situational: Only occurs with certain types of stimulation, situations, or partners |
Specify current severity: |
Mild: Evidence of mild distress over the symptoms in Criterion A |
Moderate: Evidence of moderate distress over the symptoms in Criterion A |
Severe: Evidence of severe or extreme distress over the symptoms in Criterion A |
There are no clearly specified parameters as to when a man actually meets the conditions for DE, as operationalized criteria do not exist. Perhaps a simplified strategy is to use an approach that parallels that of another male orgasmic disorder—namely premature ejaculation—in which three criteria are considered: ejaculatory latency, self-efficacy, and level of distress or bother [1, 39]. The first criterion regarding ejaculatory latency for men with DE can be based on findings that the median ejaculation time for most men is around 6–10 min (standard deviation = ± 3–4) [40, 41]. Therefore, those men who meet the following three criteria might be considered candidates for a DE diagnosis .
The man takes more than 16–20 min (i.e., ≥ about 2 standard deviations above the mean/median) to reach ejaculation or, alternatively, terminates intercourse due to frustration or exhaustion after prolonged stimulation;
The man is unable to advance his ejaculatory response, that is, he is not prolonging intercourse purposefully (a measure of self-efficacy);
The man is distressed or bothered by the situation, and/or his partner is bothered or dissatisfied by the condition.
The above characteristics, together with the fact that a man and/or his partner are sufficiently concerned or upset by the condition that they have decided to seek help for the problem, are grounds for considering a DE diagnosis.
The Lived Experiences of Men with Delayed Ejaculation
Delayed ejaculation has not attracted the same level of attention in the media as erectile dysfunction (ED) and premature ejaculation (PE) . No FDA approved medication is available for the treatment of DE (as is the case for ED), and unlike PE , pharmaceutical companies have not vigorously studied and pursued biomedical treatments for delayed ejaculation. As a result, men whose sexual relationships are disrupted by their difficulty or inability to ejaculate remain somewhat hidden from view, receiving little or no attention from the popular press and, more disconcertingly, from close and sustained investigation by the research community [11, 42]. As a result, we know little about the etiology of DE based on large study samples—for example, whether these men have always had difficulty reaching ejaculation or whether they typically develop the problem after a period of more typical ejaculatory latencies; we have little empirically based information regarding etiological factors for those men who have had a lifelong problem with reaching ejaculation; we have little understanding of the level of distress these men experience about their condition—for example, whether the difficulty or inability to reach orgasm results in levels of distress comparable to men experiencing erectile dysfunction [43] or premature ejaculation [44, 45]; and we have little insight into how the problem affects their sexual relationship.
On the other hand, sufficient numbers of men do seek help for DE to suggest that the inability to ejaculate imparts a number of psychobehavioral consequences, including diminished sexual satisfaction, low self-efficacy, and a lack of self-confidence [13, 16]. Furthermore, such men typically report a history of unsatisfying sexual relationships and, in some instances, a preference for masturbation over intercourse [14, 46]. In those instances where procreation and having a family are among the couple’s goals of sexual intercourse, delayed and/or inhibited ejaculation may be particularly troubling and frustrating to one or both partners.
Similar to men with other types of sexual dysfunction, men with DE indicate high levels of relationship distress, sexual dissatisfaction, anxiety about their sexual performance, and general health issues—significantly higher than sexually functional men. In addition, along with other sexually dysfunctional counterparts, men with DE typically report lower frequencies of coital activity [13]. A distinguishing characteristic of men with DE—and one that has implications for treatment—is that they usually have little or no difficulty attaining or keeping their erections—in fact they are often able to sustain erections for prolonged periods of time. But despite their good erections, they report lower levels of psychosexual arousal, at least compared with sexually functional men [33].
Best Practices Regarding Diagnosis
Taking an Integrated Biopsychosocial Approach
Comprehending the array of factors that account for variation in latency to ejaculation following vaginal intromission is key to understanding any sexual problem. As with many other biobehavioral responses, variation in ejaculatory latency is under the influence of both biological and psychological-behavioral factors. One contemporary way of conceptualizing the interaction of these systems has been proposed by those who study evolutionary psychology [47]. The ejaculatory latency range for each individual may be predisposed or biologically set (e.g., via genetics), but the actual timing or moment of ejaculation within that range depends on a variety of contextual, psychological-behavioral, and relationship-partner variables [16, 48]. Such thinking is clearly supported by the fact that ejaculatory latency in men with ejaculatory disorders (either premature or delayed ejaculation) is often quite different during coitus than during masturbation [49].

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