Fungal and Yeast Infections
CNS fungal infection: meningitis, meningoencephalitis, abscess, granuloma, arterial thrombosis. Subacute meningitis, meningoencephalitis most common. Lungs, skin, hair usually primary sites.
Pathogenic fungal infections (occur in normal host): histoplasmosis, blastomycosis, coccidiomycosis, paracoccidiomycosis.
Opportunistic infections (immunocompromised host): aspergillosis, candidiasis, cryptococcosis, mucormycosis, nocardiosis.
Cryptococcosis
Most common mycotic infection directly involving CNS. Major cause of morbidity and mortality among immunosuppressed patients. May simulate tuberculous meningitis, brain tumor, encephalitis, psychosis.
Pathogenesis: respiratory tract usual portal of entry. Associated with debilitating disease in 30–60%. CNS infection may occur with or without systemic disease. At diagnosis of systemic cryptococcosis, 70% have neurologic disease.Related posts:
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