Genetics of Stroke



Genetics of Stroke





Ischemic Stroke

Role of genetics incompletely understood in pathogenesis of ischemic stroke; confounded by possible environmental factors.

Documented risk factors of ischemic stroke with strong genetic influence: hypertension, hypercholesterolemia, diabetes, heart disease, obesity.

Single gene disorders rare; account for small proportion of all strokes. See below and Table 41.1.









Table 41.1 Disorders with Ischemic Stroke and Mendelian Inheritance























































Disorder Inheritance
Coagulation Disorders  
Protein C deficiency AD
Protein S deficiency AD
Activated protein C resistance Leiden type AD
Antithrombin III deficiency AD
Sickle cell disease AR
Connective tissue disorders  
Neurofibromatosis type I AD
Ehlers-Danlos syndrome type IV AD
Marfan syndrome AD
Vasculopathies  
Familial moyamoya disease Unknown
Metabolic disorders  
Fabry disease XR
MELAS AD
Homocystinuria AR
AD, autosomal dominant; AR, autosomal recessive; XR, X-linked recessive.

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Jul 27, 2016 | Posted by in NEUROLOGY | Comments Off on Genetics of Stroke

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